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MGI:Mmp2
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Mmp2 ( synonyms: 72kDa gelatinase, 72kDa type IV collagenase, Clg4a, GelA, gelatinase A, MMP-2 ) | |
| Protein Name(s) | matrix metallopeptidase 2, | |
| External Links | ||
| MGI | MGI:97009 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001525 |
angiogenesis |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0037 |
P |
From MGI |
||
| GO:0001541 |
ovarian follicle development |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0001666 |
response to hypoxia |
MGI:MGI:3721729 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0001666 |
response to hypoxia |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0001955 |
blood vessel maturation |
MGI:MGI:3621661 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1855698 |
P |
From MGI |
||
| GO:0001957 |
intramembranous ossification |
MGI:MGI:3710444 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:88467 |
P |
From MGI |
||
| GO:0001968 |
fibronectin binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0004222 |
metalloendopeptidase activity |
MGI:MGI:3607885 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004222 |
metalloendopeptidase activity |
MGI:MGI:3691773 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005576 |
extracellular region |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0964 |
C |
From MGI |
||
| GO:0005578 |
proteinaceous extracellular matrix |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0272 |
C |
From MGI |
||
| GO:0005615 |
extracellular space |
MGI:MGI:3801349 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005615 |
extracellular space |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0539 |
C |
From MGI |
||
| GO:0005737 |
cytoplasm |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:3708038 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0006508 |
proteolysis |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006979 |
response to oxidative stress |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007162 |
negative regulation of cell adhesion |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007566 |
embryo implantation |
MGI:MGI:3813178 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0008233 |
peptidase activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0008237 |
metallopeptidase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0482 |
F |
From MGI |
||
| GO:0008237 |
metallopeptidase activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0008270 |
zinc ion binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
InterPro:IPR001818 |
F |
From MGI |
||
| GO:0009612 |
response to mechanical stimulus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0014012 |
peripheral nervous system axon regeneration |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016477 |
cell migration |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0016787 |
hydrolase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0378 |
F |
From MGI |
||
| GO:0030017 |
sarcomere |
MGI:MGI:3708038 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0030574 |
collagen catabolic process |
MGI:MGI:3710444 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2386252 |
P |
From MGI |
||
| GO:0031012 |
extracellular matrix |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0042493 |
response to drug |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042542 |
response to hydrogen peroxide |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043065 |
positive regulation of apoptotic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043627 |
response to estrogen stimulus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045906 |
negative regulation of vasoconstriction |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0046872 |
metal ion binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0479 |
F |
From MGI |
||
| GO:0048705 |
skeletal system morphogenesis |
MGI:MGI:3710444 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:88467 |
P |
From MGI |
||
| GO:0048771 |
tissue remodeling |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0060325 |
face morphogenesis |
MGI:MGI:3710444 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:88467 |
P |
From MGI |
||
| GO:0060346 |
bone trabecula formation |
MGI:MGI:3710444 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:88467 |
P |
From MGI |
||
| GO:0060740 |
prostate gland epithelium morphogenesis |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0071230 |
cellular response to amino acid stimulus |
MGI:MGI:4833768 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0071392 |
cellular response to estradiol stimulus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Hou Y et al. (2007) c-Myc is essential for urokinase plasminogen activator expression on hypoxia-induced vascular smooth muscle cells. Cardiovasc Res 75: 186-94 PubMed GONUTS page
- ↑ Oh J et al. (2001) The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesis. Cell 107: 789-800 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 Egeblad M et al. (2007) Type I collagen is a genetic modifier of matrix metalloproteinase 2 in murine skeletal development. Dev Dyn 236: 1683-93 PubMed GONUTS page
- ↑ Minamitani T et al. (2002) Adhesive defect in extracellular matrix tenascin-X-null fibroblasts: a possible mechanism of tumor invasion. Biol Pharm Bull 25: 1472-5 PubMed GONUTS page
- ↑ Matsumoto K et al. (2004) Induction of matrix metalloproteinase-2 by tenascin-X deficiency is mediated through the c-Jun N-terminal kinase and protein tyrosine kinase phosphorylation pathway. Exp Cell Res 297: 404-14 PubMed GONUTS page
- ↑ Wu Y & Smas CM (2008) Wdnm1-like, a new adipokine with a role in MMP-2 activation. Am J Physiol Endocrinol Metab 295: E205-15 PubMed GONUTS page
- ↑ 7.0 7.1 Chow AK et al. (2007) Caveolin-1 inhibits matrix metalloproteinase-2 activity in the heart. J Mol Cell Cardiol 42: 896-901 PubMed GONUTS page
- ↑ Hu SJ et al. (2008) MicroRNA expression and regulation in mouse uterus during embryo implantation. J Biol Chem 283: 23473-84 PubMed GONUTS page
- ↑ Pogribny IP et al. (2010) Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice. Lab Invest 90: 1437-46 PubMed GONUTS page
