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MGI:Mme
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Mme ( synonyms: CD10, NEP, neprilysin, neutral endopeptidase ) | |
| Protein Name(s) | membrane metallo endopeptidase, | |
| External Links | ||
| MGI | MGI:97004 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001950 |
plasma membrane enriched fraction |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0004175 |
endopeptidase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0004222 |
metalloendopeptidase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005624 |
membrane fraction |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005903 |
brush border |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006508 |
proteolysis |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006508 |
proteolysis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006518 |
peptide metabolic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0008021 |
synaptic vesicle |
MGI:MGI:3604278 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0008233 |
peptidase activity |
MGI:MGI:3589585 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0008237 |
metallopeptidase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0482 |
F |
From MGI |
||
| GO:0008237 |
metallopeptidase activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0008270 |
zinc ion binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:3589585 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0016021 |
integral to membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0812 |
C |
From MGI |
||
| GO:0016787 |
hydrolase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0378 |
F |
From MGI |
||
| GO:0019233 |
sensory perception of pain |
MGI:MGI:5315379 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0030424 |
axon |
MGI:MGI:3604278 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0030425 |
dendrite |
MGI:MGI:3604278 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0042277 |
peptide binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0044306 |
neuron projection terminus |
MGI:MGI:3604278 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0045202 |
synapse |
MGI:MGI:3604278 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0046449 |
creatinine metabolic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0046872 |
metal ion binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0479 |
F |
From MGI |
||
| GO:0050435 |
beta-amyloid metabolic process |
MGI:MGI:3604278 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0071345 |
cellular response to cytokine stimulus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0071492 |
cellular response to UV-A |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0071493 |
cellular response to UV-B |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Fukami S et al. (2002) Abeta-degrading endopeptidase, neprilysin, in mouse brain: synaptic and axonal localization inversely correlating with Abeta pathology. Neurosci Res 43: 39-56 PubMed GONUTS page
- ↑ 2.0 2.1 Pardossi-Piquard R et al. (2005) Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP. Neuron 46: 541-54 PubMed GONUTS page
- ↑ Chen H et al. (1998) Aminophosphinic inhibitors as transition state analogues of enkephalin-degrading enzymes: a class of central analgesics. Proc Natl Acad Sci U S A 95: 12028-33 PubMed GONUTS page
