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MGI:Mlph
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Mlph ( synonyms: D1Wsu84e, l(1)-3Rk, l1Rk3, Slac-2a ) | |
| Protein Name(s) | melanophilin, | |
| External Links | ||
| MGI | MGI:2176380 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001725 |
stress fiber |
MGI:MGI:3611941 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0003779 |
actin binding |
MGI:MGI:2429450 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:2176311 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3611941 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:4412434 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:2177987 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856674 |
C |
From MGI |
||
| GO:0005622 |
intracellular |
MGI:MGI:3614727 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856674 |
C |
From MGI |
||
| GO:0005815 |
microtubule organizing center |
MGI:MGI:3611941 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0006605 |
protein targeting |
MGI:MGI:2177987 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856674 |
P |
From MGI |
||
| GO:0006605 |
protein targeting |
MGI:MGI:3614727 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856674 |
P |
From MGI |
||
| GO:0006886 |
intracellular protein transport |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0015629 |
actin cytoskeleton |
MGI:MGI:2429450 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0017022 |
myosin binding |
MGI:MGI:2664301 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0017137 |
Rab GTPase binding |
MGI:MGI:2664301 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0030318 |
melanocyte differentiation |
MGI:MGI:2149529 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856674 |
P |
From MGI |
||
| GO:0030318 |
melanocyte differentiation |
MGI:MGI:77000 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856674 |
P |
From MGI |
||
| GO:0030864 |
cortical actin cytoskeleton |
MGI:MGI:3611941 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0031489 |
myosin V binding |
MGI:MGI:2177987 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0031489 |
myosin V binding |
MGI:MGI:3028456 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0032400 |
melanosome localization |
MGI:MGI:2177987 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856674 |
P |
From MGI |
||
| GO:0032400 |
melanosome localization |
MGI:MGI:3028456 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0032400 |
melanosome localization |
MGI:MGI:3614727 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856674 |
P |
From MGI |
||
| GO:0035371 |
microtubule plus end |
MGI:MGI:3611941 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0042470 |
melanosome |
MGI:MGI:2177987 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0042470 |
melanosome |
MGI:MGI:2429450 |
TAS: Traceable Author Statement |
C |
From MGI |
|||
| GO:0042470 |
melanosome |
MGI:MGI:2664301 |
TAS: Traceable Author Statement |
C |
From MGI |
|||
| GO:0042470 |
melanosome |
MGI:MGI:3028456 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0042470 |
melanosome |
MGI:MGI:3590364 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0042470 |
melanosome |
MGI:MGI:3611941 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0043473 |
pigmentation |
MGI:MGI:61184 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856674 |
P |
From MGI |
||
| GO:0043473 |
pigmentation |
MGI:MGI:77000 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856674 |
P |
From MGI |
||
| GO:0046872 |
metal ion binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0479 |
F |
From MGI |
||
| GO:0051010 |
microtubule plus-end binding |
MGI:MGI:3590364 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Wu XS et al. (2005) Melanophilin and myosin Va track the microtubule plus end on EB1. J Cell Biol 171: 201-7 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Fukuda M & Kuroda TS (2002) Slac2-c (synaptotagmin-like protein homologue lacking C2 domains-c), a novel linker protein that interacts with Rab27, myosin Va/VIIa, and actin. J Biol Chem 277: 43096-103 PubMed GONUTS page
- ↑ Kuroda TS et al. (2002) The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain. J Biol Chem 277: 9212-8 PubMed GONUTS page
- ↑ Kukimoto-Niino M et al. (2008) Structural basis for the exclusive specificity of Slac2-a/melanophilin for the Rab27 GTPases. Structure 16: 1478-90 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 Wu XS et al. (2002) Identification of an organelle receptor for myosin-Va. Nat Cell Biol 4: 271-8 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Hume AN et al. (2002) The leaden gene product is required with Rab27a to recruit myosin Va to melanosomes in melanocytes. Traffic 3: 193-202 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 Fukuda M et al. (2002) Slac2-a/melanophilin, the missing link between Rab27 and myosin Va: implications of a tripartite protein complex for melanosome transport. J Biol Chem 277: 12432-6 PubMed GONUTS page
- ↑ Matesic LE et al. (2001) Mutations in Mlph, encoding a member of the Rab effector family, cause the melanosome transport defects observed in leaden mice. Proc Natl Acad Sci U S A 98: 10238-43 PubMed GONUTS page
- ↑ 9.0 9.1 Moore KJ et al. (1990) Interaction of the murine dilute suppressor gene (dsu) with fourteen coat color mutations. Genetics 125: 421-30 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 Fukuda M & Kuroda TS (2004) Missense mutations in the globular tail of myosin-Va in dilute mice partially impair binding of Slac2-a/melanophilin. J Cell Sci 117: 583-91 PubMed GONUTS page
- ↑ 11.0 11.1 Volkmann N et al. (2005) The structural basis of myosin V processive movement as revealed by electron cryomicroscopy. Mol Cell 19: 595-605 PubMed GONUTS page
- ↑ Markert CL & Silvers WK (1956) The Effects of Genotype and Cell Environment on Melanoblast Differentiation in the House Mouse. Genetics 41: 429-50 PubMed GONUTS page
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