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MGI:Mllt4

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Contents

Species (Taxon ID) Mus musculus (house mouse) (taxon:10090)
Gene Name(s) Mllt4 ( synonyms: AF6, Afadin, I-afadin, S-afadin )
Protein Name(s) myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4,
External Links
MGI MGI:1314653

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005515

protein binding

MGI:MGI:2449841
PMID:12446711[1]

IPI: Inferred from Physical Interaction

UniProtKB:Q8VC66

F

From MGI

GO:0005634

nucleus

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:A8MQ02

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:3056245
PMID:15509704[2]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:A8MQ02

C

From MGI

GO:0005886

plasma membrane

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:A8MQ02

C

From MGI

GO:0005911

cell-cell junction

MGI:MGI:3835718
PMID:18604197[3]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005912

adherens junction

MGI:MGI:2386382
PMID:12203721[4]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005912

adherens junction

MGI:MGI:2450499
PMID:12515806[5]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005913

cell-cell adherens junction

MGI:MGI:2154851
PMID:11731229[6]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005913

cell-cell adherens junction

MGI:MGI:3604842
PMID:15728677[7]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005913

cell-cell adherens junction

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:O35889

C

From MGI

GO:0007155

cell adhesion

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0130

P

From MGI

GO:0007165

signal transduction

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR000159

P

From MGI

GO:0030054

cell junction

MGI:MGI:3056245
PMID:15509704[2]

IDA: Inferred from Direct Assay

C

From MGI

GO:0030054

cell junction

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:A8MQ02

C

From MGI

GO:0030274

LIM domain binding

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:O35889

F

From MGI

GO:0045177

apical part of cell

MGI:MGI:1354817
PMID:10704870[8]

IDA: Inferred from Direct Assay

C

From MGI

GO:0050839

cell adhesion molecule binding

MGI:MGI:3828417
PMID:10225955[9]

IPI: Inferred from Physical Interaction

UniProtKB:P32507

F

From MGI


Notes

References

See Help:References for how to manage references in GONUTS.
  1. Asada M et al. (2003) ADIP, a novel Afadin- and alpha-actinin-binding protein localized at cell-cell adherens junctions. J Biol Chem 278: 4103-11 PubMed GONUTS page
  2. 2.0 2.1 Sato T et al. (2004) A close correlation in the expression patterns of Af-6 and Usp9x in Sertoli and granulosa cells of mouse testis and ovary. Reproduction 128: 583-94 PubMed GONUTS page
  3. Nojima H et al. (2008) IQGAP3 regulates cell proliferation through the Ras/ERK signalling cascade. Nat Cell Biol 10: 971-8 PubMed GONUTS page
  4. Manabe N et al. (2002) Association of ASIP/mPAR-3 with adherens junctions of mouse neuroepithelial cells. Dev Dyn 225: 61-9 PubMed GONUTS page
  5. Takekuni K et al. (2003) Direct binding of cell polarity protein PAR-3 to cell-cell adhesion molecule nectin at neuroepithelial cells of developing mouse. J Biol Chem 278: 5497-500 PubMed GONUTS page
  6. Pantaleon M et al. (2001) FAM deubiquitylating enzyme is essential for preimplantation mouse embryo development. Mech Dev 109: 151-60 PubMed GONUTS page
  7. Inagaki M et al. (2005) Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development. Development 132: 1525-37 PubMed GONUTS page
  8. Kanai-Azuma M et al. (2000) Co-localization of FAM and AF-6, the mammalian homologues of Drosophila faf and canoe, in mouse eye development. Mech Dev 91: 383-6 PubMed GONUTS page
  9. Takahashi K et al. (1999) Nectin/PRR: an immunoglobulin-like cell adhesion molecule recruited to cadherin-based adherens junctions through interaction with Afadin, a PDZ domain-containing protein. J Cell Biol 145: 539-49 PubMed GONUTS page
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