GONUTS is under stress! The website is currently experiencing long-wait times and frequent time-outs due to the record number of students, groups, and annotations related to CACAO this semester. We are currently working on increasing performance -- please accept our apologies for the technical difficulties.
You can help reduce stress on the server by:
- not reloading pages frequently - this just adds
- opening links in new windows (so you can read the old page)
MGI:Mkl2
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Mkl2 ( synonyms: Gt4-1, MRTF-B, Mrtfb ) | |
| Protein Name(s) | MKL/myocardin-like 2, | |
| External Links | ||
| MGI | MGI:3050795 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001701 |
in utero embryonic development |
MGI:MGI:3695837 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3587937 |
P |
From MGI |
||
| GO:0001889 |
liver development |
MGI:MGI:3695837 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3587937 |
P |
From MGI |
||
| GO:0003007 |
heart morphogenesis |
MGI:MGI:3695837 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3587937 |
P |
From MGI |
||
| GO:0003676 |
nucleic acid binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0003713 |
transcription coactivator activity |
MGI:MGI:2663933 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003713 |
transcription coactivator activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0003779 |
actin binding |
MGI:MGI:3575983 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:2663933 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:2663933 |
IC: Inferred by Curator |
GO:0003713 |
C |
From MGI |
||
| GO:0005737 |
cytoplasm |
MGI:MGI:3575983 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0006351 |
transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0804 |
P |
From MGI |
||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0805 |
P |
From MGI |
||
| GO:0007275 |
multicellular organismal development |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0217 |
P |
From MGI |
||
| GO:0007507 |
heart development |
MGI:MGI:3607644 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3608959 |
P |
From MGI |
||
| GO:0007517 |
muscle organ development |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0517 |
P |
From MGI |
||
| GO:0010467 |
gene expression |
MGI:MGI:3695837 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3587937 |
P |
From MGI |
||
| GO:0010468 |
regulation of gene expression |
MGI:MGI:3695837 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3587937 |
P |
From MGI |
||
| GO:0030154 |
cell differentiation |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0221 |
P |
From MGI |
||
| GO:0045844 |
positive regulation of striated muscle tissue development |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
MGI:MGI:3575983 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:2663933 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3831457 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0048514 |
blood vessel morphogenesis |
MGI:MGI:3607644 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3608959 |
P |
From MGI |
||
| GO:0048568 |
embryonic organ development |
MGI:MGI:3695837 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3587937 |
P |
From MGI |
||
| GO:0048738 |
cardiac muscle tissue development |
MGI:MGI:3695837 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3587937 |
P |
From MGI |
||
| GO:0051145 |
smooth muscle cell differentiation |
MGI:MGI:3607644 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3608959 |
P |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Wei K et al. (2007) Myocardin-related transcription factor B is required for normal mouse vascular development and smooth muscle gene expression. Dev Dyn 236: 416-25 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Wang DZ et al. (2002) Potentiation of serum response factor activity by a family of myocardin-related transcription factors. Proc Natl Acad Sci U S A 99: 14855-60 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Kuwahara K et al. (2005) Muscle-specific signaling mechanism that links actin dynamics to serum response factor. Mol Cell Biol 25: 3173-81 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Oh J et al. (2005) Requirement of myocardin-related transcription factor-B for remodeling of branchial arch arteries and smooth muscle differentiation. Proc Natl Acad Sci U S A 102: 15122-7 PubMed GONUTS page
- ↑ Zhou J et al. (2008) Thymine DNA glycosylase represses myocardin-induced smooth muscle cell differentiation by competing with serum response factor for myocardin binding. J Biol Chem 283: 35383-92 PubMed GONUTS page
