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MGI:Mif
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Mif ( synonyms: Glif ) | |
| Protein Name(s) | macrophage migration inhibitory factor, | |
| External Links | ||
| MGI | MGI:96982 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001516 |
prostaglandin biosynthetic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0001934 |
positive regulation of protein phosphorylation |
MGI:MGI:4437204 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0002035 |
brain renin-angiotensin system |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0002675 |
positive regulation of acute inflammatory response |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0002821 |
positive regulation of adaptive immune response |
MGI:MGI:3773489 |
NAS: Non-traceable Author Statement |
P |
From MGI |
|||
| GO:0002906 |
negative regulation of mature B cell apoptotic process |
MGI:MGI:3773489 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0004167 |
dopachrome isomerase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005102 |
receptor binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005125 |
cytokine activity |
MGI:MGI:3690285 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005125 |
cytokine activity |
MGI:MGI:4437204 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005125 |
cytokine activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005126 |
cytokine receptor binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005576 |
extracellular region |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005615 |
extracellular space |
MGI:MGI:2156302 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005615 |
extracellular space |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:2670239 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2673280 |
C |
From MGI |
||
| GO:0005634 |
nucleus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006954 |
inflammatory response |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0395 |
P |
From MGI |
||
| GO:0007166 |
cell surface receptor signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007283 |
spermatogenesis |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007569 |
cell aging |
MGI:MGI:2670239 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2673280 |
P |
From MGI |
||
| GO:0008283 |
cell proliferation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0009986 |
cell surface |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0010629 |
negative regulation of gene expression |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0010739 |
positive regulation of protein kinase A signaling cascade |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0014911 |
positive regulation of smooth muscle cell migration |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0016853 |
isomerase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0413 |
F |
From MGI |
||
| GO:0019752 |
carboxylic acid metabolic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030330 |
DNA damage response, signal transduction by p53 class mediator |
MGI:MGI:2670239 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2673280 |
P |
From MGI |
||
| GO:0030890 |
positive regulation of B cell proliferation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0031666 |
positive regulation of lipopolysaccharide-mediated signaling pathway |
MGI:MGI:2156302 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0032269 |
negative regulation of cellular protein metabolic process |
MGI:MGI:2156302 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0032403 |
protein complex binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0033033 |
negative regulation of myeloid cell apoptotic process |
MGI:MGI:2156302 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0033138 |
positive regulation of peptidyl-serine phosphorylation |
MGI:MGI:3690285 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0033138 |
positive regulation of peptidyl-serine phosphorylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042056 |
chemoattractant activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0042127 |
regulation of cell proliferation |
MGI:MGI:2670239 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2673280 |
P |
From MGI |
||
| GO:0042327 |
positive regulation of phosphorylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042756 |
drinking behavior |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043066 |
negative regulation of apoptotic process |
MGI:MGI:3690285 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0043066 |
negative regulation of apoptotic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043268 |
positive regulation of potassium ion transport |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043406 |
positive regulation of MAP kinase activity |
MGI:MGI:4437204 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0043498 |
cell surface binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0043518 |
negative regulation of DNA damage response, signal transduction by p53 class mediator |
MGI:MGI:3690285 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0043518 |
negative regulation of DNA damage response, signal transduction by p53 class mediator |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045087 |
innate immune response |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0399 |
P |
From MGI |
||
| GO:0045821 |
positive regulation of glycolysis |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0046326 |
positive regulation of glucose import |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0048146 |
positive regulation of fibroblast proliferation |
MGI:MGI:4437204 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0048146 |
positive regulation of fibroblast proliferation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0048680 |
positive regulation of axon regeneration |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0050178 |
phenylpyruvate tautomerase activity |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0050178 |
phenylpyruvate tautomerase activity |
MGI:MGI:3610590 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2176337 |
F |
From MGI |
||
| GO:0050715 |
positive regulation of cytokine secretion |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0050731 |
positive regulation of peptidyl-tyrosine phosphorylation |
MGI:MGI:3690285 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0050731 |
positive regulation of peptidyl-tyrosine phosphorylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0050778 |
positive regulation of immune response |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0050918 |
positive chemotaxis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0061078 |
positive regulation of prostaglandin secretion involved in immune response |
MGI:MGI:2156302 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0061081 |
positive regulation of myeloid leukocyte cytokine production involved in immune response |
MGI:MGI:2156302 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0070207 |
protein homotrimerization |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0070374 |
positive regulation of ERK1 and ERK2 cascade |
MGI:MGI:3690285 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0070374 |
positive regulation of ERK1 and ERK2 cascade |
MGI:MGI:4437204 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0070374 |
positive regulation of ERK1 and ERK2 cascade |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0071157 |
negative regulation of cell cycle arrest |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0090238 |
positive regulation of arachidonic acid secretion |
MGI:MGI:4437204 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0090344 |
negative regulation of cell aging |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:2000343 |
positive regulation of chemokine (C-X-C motif) ligand 2 production |
MGI:MGI:3773489 |
IDA: Inferred from Direct Assay |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Mitchell RA et al. (1999) Sustained mitogen-activated protein kinase (MAPK) and cytoplasmic phospholipase A2 activation by macrophage migration inhibitory factor (MIF). Regulatory role in cell proliferation and glucocorticoid action. J Biol Chem 274: 18100-6 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Gore Y et al. (2008) Macrophage migration inhibitory factor induces B cell survival by activation of a CD74-CD44 receptor complex. J Biol Chem 283: 2784-92 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 Shi X et al. (2006) CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex. Immunity 25: 595-606 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 Mitchell RA et al. (2002) Macrophage migration inhibitory factor (MIF) sustains macrophage proinflammatory function by inhibiting p53: regulatory role in the innate immune response. Proc Natl Acad Sci U S A 99: 345-50 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 Fingerle-Rowson G et al. (2003) The p53-dependent effects of macrophage migration inhibitory factor revealed by gene targeting. Proc Natl Acad Sci U S A 100: 9354-9 PubMed GONUTS page
- ↑ Wilson JM et al. (2005) Macrophage migration inhibitory factor promotes intestinal tumorigenesis. Gastroenterology 129: 1485-503 PubMed GONUTS page
