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MGI:Mgmt
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Mgmt ( synonyms: Agat, AGT ) | |
| Protein Name(s) | O-6-methylguanine-DNA methyltransferase, | |
| External Links | ||
| MGI | MGI:96977 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0003677 |
DNA binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0238 |
F |
From MGI |
||
| GO:0003824 |
catalytic activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0003908 |
methylated-DNA-(protein)-cysteine S-methyltransferase activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005509 |
calcium ion binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006281 |
DNA repair |
MGI:MGI:2677087 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0006307 |
DNA dealkylation involved in DNA repair |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006307 |
DNA dealkylation involved in DNA repair |
MGI:MGI:50172 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006974 |
response to DNA damage stimulus |
MGI:MGI:1203882 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857949 |
P |
From MGI |
||
| GO:0006974 |
response to DNA damage stimulus |
MGI:MGI:1353727 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857949 |
P |
From MGI |
||
| GO:0008152 |
metabolic process |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0808 |
P |
From MGI |
||
| GO:0008152 |
metabolic process |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0008168 |
methyltransferase activity |
MGI:MGI:1203882 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0008168 |
methyltransferase activity |
MGI:MGI:50172 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0016740 |
transferase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0808 |
F |
From MGI |
||
| GO:0032259 |
methylation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043281 |
regulation of cysteine-type endopeptidase activity involved in apoptotic process |
MGI:MGI:2677087 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0045739 |
positive regulation of DNA repair |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0046872 |
metal ion binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0479 |
F |
From MGI |
||
| GO:0060548 |
negative regulation of cell death |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Takagi Y et al. (2003) Roles of MGMT and MLH1 proteins in alkylation-induced apoptosis and mutagenesis. DNA Repair (Amst) 2: 1135-46 PubMed GONUTS page
- ↑ 2.0 2.1 Santibanez-Koref M et al. (1992) Isolation and partial characterization of murine O6-alkylguanine-DNA-alkyltransferase: comparative sequence and structural properties. Mol Carcinog 5: 161-9 PubMed GONUTS page
- ↑ 3.0 3.1 Kawate H et al. (1998) Separation of killing and tumorigenic effects of an alkylating agent in mice defective in two of the DNA repair genes. Proc Natl Acad Sci U S A 95: 5116-20 PubMed GONUTS page
- ↑ Kawate H et al. (2000) A defect in a single allele of the Mlh1 gene causes dissociation of the killing and tumorigenic actions of an alkylating carcinogen in methyltransferase-deficient mice. Carcinogenesis 21: 301-5 PubMed GONUTS page
