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MGI:Met
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Met ( synonyms: c-Met, HGF receptor, Par4 ) | |
| Protein Name(s) | met proto-oncogene, | |
| External Links | ||
| MGI | MGI:96969 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0000166 |
nucleotide binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0547 |
F |
From MGI |
||
| GO:0000187 |
activation of MAPK activity |
MGI:MGI:3054501 |
IPI: Inferred from Physical Interaction |
P |
From MGI |
|||
| GO:0001764 |
neuron migration |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0001889 |
liver development |
MGI:MGI:76093 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857655 |
P |
From MGI |
||
| GO:0001890 |
placenta development |
MGI:MGI:76093 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857655 |
P |
From MGI |
||
| GO:0004672 |
protein kinase activity |
MGI:MGI:76093 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004713 |
protein tyrosine kinase activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0004872 |
receptor activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0675 |
F |
From MGI |
||
| GO:0005008 |
hepatocyte growth factor-activated receptor activity |
MGI:MGI:3054501 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005008 |
hepatocyte growth factor-activated receptor activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005524 |
ATP binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0067 |
F |
From MGI |
||
| GO:0005615 |
extracellular space |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005624 |
membrane fraction |
MGI:MGI:76926 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0007420 |
brain development |
MGI:MGI:2450013 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2450967 |
P |
From MGI |
||
| GO:0007517 |
muscle organ development |
MGI:MGI:3505795 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:97487 |
P |
From MGI |
||
| GO:0007517 |
muscle organ development |
MGI:MGI:3505795 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1858019 |
P |
From MGI |
||
| GO:0007519 |
skeletal muscle tissue development |
MGI:MGI:76093 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857655 |
P |
From MGI |
||
| GO:0008013 |
beta-catenin binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0009925 |
basal plasma membrane |
MGI:MGI:3054501 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0010628 |
positive regulation of gene expression |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0010800 |
positive regulation of peptidyl-threonine phosphorylation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0010801 |
negative regulation of peptidyl-threonine phosphorylation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0010828 |
positive regulation of glucose transport |
MGI:MGI:3584289 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2176227 |
P |
From MGI |
||
| GO:0010976 |
positive regulation of neuron projection development |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0014069 |
postsynaptic density |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0014812 |
muscle cell migration |
MGI:MGI:76093 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857655 |
P |
From MGI |
||
| GO:0014902 |
myotube differentiation |
MGI:MGI:76093 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857655 |
P |
From MGI |
||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016021 |
integral to membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0812 |
C |
From MGI |
||
| GO:0016301 |
kinase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0418 |
F |
From MGI |
||
| GO:0016310 |
phosphorylation |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0418 |
P |
From MGI |
||
| GO:0016740 |
transferase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0808 |
F |
From MGI |
||
| GO:0019861 |
flagellum |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0030317 |
sperm motility |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030425 |
dendrite |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0030534 |
adult behavior |
MGI:MGI:2450013 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2450967 |
P |
From MGI |
||
| GO:0032403 |
protein complex binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0033138 |
positive regulation of peptidyl-serine phosphorylation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042593 |
glucose homeostasis |
MGI:MGI:3584289 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2176227 |
P |
From MGI |
||
| GO:0043005 |
neuron projection |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0043025 |
neuronal cell body |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0043274 |
phospholipase binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0043548 |
phosphatidylinositol 3-kinase binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0045211 |
postsynaptic membrane |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0045740 |
positive regulation of DNA replication |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045840 |
positive regulation of mitosis |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0046777 |
protein autophosphorylation |
MGI:MGI:3054501 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0046777 |
protein autophosphorylation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0046982 |
protein heterodimerization activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0048012 |
hepatocyte growth factor receptor signaling pathway |
MGI:MGI:3054501 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0048012 |
hepatocyte growth factor receptor signaling pathway |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0048754 |
branching morphogenesis of a tube |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0050775 |
positive regulation of dendrite morphogenesis |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0051450 |
myoblast proliferation |
MGI:MGI:3618663 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1858021 |
P |
From MGI |
||
| GO:0060076 |
excitatory synapse |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0060665 |
regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling |
MGI:MGI:2677549 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Higuchi T et al. (2004) MUC20 suppresses the hepatocyte growth factor-induced Grb2-Ras pathway by binding to a multifunctional docking site of met. Mol Cell Biol 24: 7456-68 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Bladt F et al. (1995) Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud. Nature 376: 768-71 PubMed GONUTS page
- ↑ Komada M & Kitamura N (1995) Growth factor-induced tyrosine phosphorylation of Hrs, a novel 115-kilodalton protein with a structurally conserved putative zinc finger domain. Mol Cell Biol 15: 6213-21 PubMed GONUTS page
- ↑ 4.0 4.1 Ieraci A et al. (2002) Viable hypomorphic signaling mutant of the Met receptor reveals a role for hepatocyte growth factor in postnatal cerebellar development. Proc Natl Acad Sci U S A 99: 15200-5 PubMed GONUTS page
- ↑ 5.0 5.1 Prunotto C et al. (2004) Analysis of Mlc-lacZ Met mutants highlights the essential function of Met for migratory precursors of hypaxial muscles and reveals a role for Met in the development of hyoid arch-derived facial muscles. Dev Dyn 231: 582-91 PubMed GONUTS page
- ↑ 6.0 6.1 Dai C et al. (2005) Beta-cell-specific ablation of the hepatocyte growth factor receptor results in reduced islet size, impaired insulin secretion, and glucose intolerance. Am J Pathol 167: 429-36 PubMed GONUTS page
- ↑ Ponzetto C et al. (2000) Met signaling mutants as tools for developmental studies. Int J Dev Biol 44: 645-53 PubMed GONUTS page
- ↑ Ikari T et al. (2003) Involvement of hepatocyte growth factor in branching morphogenesis of murine salivary gland. Dev Dyn 228: 173-84 PubMed GONUTS page
