GONUTS is under stress! The website is currently experiencing long-wait times and frequent time-outs due to the record number of students, groups, and annotations related to CACAO this semester. We are currently working on increasing performance -- please accept our apologies for the technical difficulties.
You can help reduce stress on the server by:
- not reloading pages frequently - this just adds
- opening links in new windows (so you can read the old page)
MGI:Mertk
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Mertk ( synonyms: Eyk, Mer, nmf12, Nyk, Tyro 12 ) | |
| Protein Name(s) | c-mer proto-oncogene tyrosine kinase, | |
| External Links | ||
| MGI | MGI:96965 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000166 |
nucleotide binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0547 |
F |
From MGI |
||
| GO:0001750 |
photoreceptor outer segment |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0001779 |
natural killer cell differentiation |
MGI:MGI:3662985 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:104294 |
P |
From MGI |
||
| GO:0004672 |
protein kinase activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0004713 |
protein tyrosine kinase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0829 |
F |
From MGI |
||
| GO:0004713 |
protein tyrosine kinase activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0004714 |
transmembrane receptor protein tyrosine kinase activity |
MGI:MGI:2152096 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0004872 |
receptor activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0675 |
F |
From MGI |
||
| GO:0005524 |
ATP binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0067 |
F |
From MGI |
||
| GO:0005524 |
ATP binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005615 |
extracellular space |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:3528131 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:95660 |
C |
From MGI |
||
| GO:0005623 |
cell |
MGI:MGI:3528131 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2387765 |
C |
From MGI |
||
| GO:0005737 |
cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006468 |
protein phosphorylation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006909 |
phagocytosis |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006909 |
phagocytosis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007165 |
signal transduction |
MGI:MGI:2152096 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0007283 |
spermatogenesis |
MGI:MGI:1335700 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:104294 |
P |
From MGI |
||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016021 |
integral to membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0812 |
C |
From MGI |
||
| GO:0016028 |
rhabdomere |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0016301 |
kinase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0418 |
F |
From MGI |
||
| GO:0016310 |
phosphorylation |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0418 |
P |
From MGI |
||
| GO:0016740 |
transferase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0808 |
F |
From MGI |
||
| GO:0016772 |
transferase activity, transferring phosphorus-containing groups |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0030168 |
platelet activation |
MGI:MGI:3528131 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2387765 |
P |
From MGI |
||
| GO:0032940 |
secretion by cell |
MGI:MGI:3528131 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2387765 |
P |
From MGI |
||
| GO:0034446 |
substrate adhesion-dependent cell spreading |
MGI:MGI:3528131 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2387765 |
P |
From MGI |
||
| GO:0043277 |
apoptotic cell clearance |
MGI:MGI:3778590 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:104294 |
P |
From MGI |
||
| GO:0043277 |
apoptotic cell clearance |
MGI:MGI:3778590 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0043277 |
apoptotic cell clearance |
MGI:MGI:3836130 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2387768 |
P |
From MGI |
||
| GO:0043491 |
protein kinase B signaling cascade |
MGI:MGI:3528131 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:95660 |
P |
From MGI |
||
| GO:0050766 |
positive regulation of phagocytosis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0051250 |
negative regulation of lymphocyte activation |
MGI:MGI:2137182 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:104294 |
P |
From MGI |
||
| GO:0060041 |
retina development in camera-type eye |
MGI:MGI:4849309 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0060068 |
vagina development |
MGI:MGI:3820485 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:104294 |
P |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Caraux A et al. (2006) Natural killer cell differentiation driven by Tyro3 receptor tyrosine kinases. Nat Immunol 7: 747-54 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Angelillo-Scherrer A et al. (2005) Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy. J Clin Invest 115: 237-46 PubMed GONUTS page
- ↑ Lu Q et al. (1999) Tyro-3 family receptors are essential regulators of mammalian spermatogenesis. Nature 398: 723-8 PubMed GONUTS page
- ↑ 4.0 4.1 Xiong W et al. (2008) Gas6 and the Tyro 3 receptor tyrosine kinase subfamily regulate the phagocytic function of Sertoli cells. Reproduction 135: 77-87 PubMed GONUTS page
- ↑ Seitz HM et al. (2007) Macrophages and dendritic cells use different Axl/Mertk/Tyro3 receptors in clearance of apoptotic cells. J Immunol 178: 5635-42 PubMed GONUTS page
- ↑ Lu Q & Lemke G (2001) Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family. Science 293: 306-11 PubMed GONUTS page
- ↑ Won J et al. (2011) Mouse model resources for vision research. J Ophthalmol 2011: 391384 PubMed GONUTS page
- ↑ Wu H et al. (2008) High incidence of distal vaginal atresia in mice lacking Tyro3 RTK subfamily. Mol Reprod Dev 75: 1775-82 PubMed GONUTS page
