MGI:Men1

From GONUTS

Jump to: navigation, search

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	MGI:MGI:3616131 PMID:15044367^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O00255	P	From MGI
	GO:0000165	MAPK cascade	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O00255	P	From MGI
	GO:0000400	four-way junction DNA binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O00255	F	From MGI
	GO:0000403	Y-form DNA binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O00255	F	From MGI
	GO:0000785	chromatin	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O00255	C	From MGI
	GO:0001503	ossification	MGI:MGI:3763871 PMID:17927973^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2683274 MGI:MGI:3573783	P	From MGI
	GO:0001776	leukocyte homeostasis	MGI:MGI:3616364 PMID:16415155^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158697	P	From MGI
	GO:0001933	negative regulation of protein phosphorylation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O00255	P	From MGI
	GO:0002051	osteoblast fate commitment	MGI:MGI:3056877 PMID:15150273^[4]	IGI: Inferred from Genetic Interaction	MGI:MGI:109452 MGI:MGI:1328787 MGI:MGI:99829	P	From MGI
	GO:0002076	osteoblast development	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:O00255	P	From MGI
	GO:0002076	osteoblast development	MGI:MGI:3056877 PMID:15150273^[4]	IGI: Inferred from Genetic Interaction	MGI:MGI:1201674	P	From MGI
	GO:0002076	osteoblast development	MGI:MGI:3573815 PMID:15563473^[5]	IGI: Inferred from Genetic Interaction	MGI:MGI:96648	P	From MGI
	GO:0003677	DNA binding	MGI:MGI:3035842 PMID:14992727^[6]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003682	chromatin binding	MGI:MGI:3529753 PMID:15640349^[7]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003682	chromatin binding	MGI:MGI:3607663 PMID:16195383^[8]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003682	chromatin binding	MGI:MGI:3616364 PMID:16415155^[3]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003690	double-stranded DNA binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O00255	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3056877 PMID:15150273^[4]	IPI: Inferred from Physical Interaction	UniProtKB:Q8BUN5 UniProtKB:P97454 UniProtKB:P70340 UniProtKB:Q08775	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3625774 PMID:16618927^[9]	IPI: Inferred from Physical Interaction	UniProtKB:P55200	F	From MGI
	GO:0005625	soluble fraction	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O00255	C	From MGI
	GO:0005634	nucleus	MGI:MGI:1314826 PMID:9824159^[10]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:O00255	C	From MGI
	GO:0005634	nucleus	MGI:MGI:2672975 PMID:12941803^[11]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:3056877 PMID:15150273^[4]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:3607663 PMID:16195383^[8]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:3692834 PMID:17044021^[12]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:3718866 PMID:17500065^[13]	ISO: Inferred from Sequence Orthology	UniProtKB:O00255	C	From MGI
	GO:0005634	nucleus	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_062081	C	From MGI
	GO:0005634	nucleus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:E7EN32	C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:1314826 PMID:9824159^[10]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:E7EN32	C	From MGI
	GO:0005829	cytosol	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O00255	C	From MGI
	GO:0006338	chromatin remodeling	MGI:MGI:3616131 PMID:15044367^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158698	P	From MGI
	GO:0006338	chromatin remodeling	MGI:MGI:3616364 PMID:16415155^[3]	IGI: Inferred from Genetic Interaction	MGI:MGI:88393	P	From MGI
	GO:0006351	transcription, DNA-dependent	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0804	P	From MGI
	GO:0006355	regulation of transcription, DNA-dependent	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0805	P	From MGI
	GO:0006974	response to DNA damage stimulus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O00255	P	From MGI
	GO:0007050	cell cycle arrest	MGI:MGI:3639378 PMID:16740708^[14]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158697 MGI:MGI:3663673	P	From MGI
	GO:0008285	negative regulation of cell proliferation	MGI:MGI:1929921 PMID:11158604^[15]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158698	P	From MGI
	GO:0008285	negative regulation of cell proliferation	MGI:MGI:2672975 PMID:12941803^[11]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2675250 MGI:MGI:2387567	P	From MGI
	GO:0008285	negative regulation of cell proliferation	MGI:MGI:2681015 PMID:14633735^[16]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2683274 MGI:MGI:2683304	P	From MGI
	GO:0008285	negative regulation of cell proliferation	MGI:MGI:3041905 PMID:15060136^[17]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2384620 MGI:MGI:2176227	P	From MGI
	GO:0008285	negative regulation of cell proliferation	MGI:MGI:3529753 PMID:15640349^[7]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0008285	negative regulation of cell proliferation	MGI:MGI:3607663 PMID:16195383^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3608952	P	From MGI
	GO:0008285	negative regulation of cell proliferation	MGI:MGI:3616131 PMID:15044367^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0008285	negative regulation of cell proliferation	MGI:MGI:3639378 PMID:16740708^[14]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158697 MGI:MGI:3663673	P	From MGI
	GO:0008285	negative regulation of cell proliferation	MGI:MGI:3708062 PMID:17409423^[18]	IGI: Inferred from Genetic Interaction	MGI:MGI:105388	P	From MGI
	GO:0008285	negative regulation of cell proliferation	MGI:MGI:3763020 PMID:17975067^[19]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0008285	negative regulation of cell proliferation	MGI:MGI:3763871 PMID:17927973^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2683274 MGI:MGI:3573783	P	From MGI
	GO:0008285	negative regulation of cell proliferation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O00255	P	From MGI
	GO:0009411	response to UV	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O00255	P	From MGI
	GO:0009790	embryo development	MGI:MGI:1929921 PMID:11158604^[15]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158698	P	From MGI
	GO:0010332	response to gamma radiation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O00255	P	From MGI
	GO:0016363	nuclear matrix	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O00255	C	From MGI
	GO:0016568	chromatin modification	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0156	P	From MGI
	GO:0016571	histone methylation	MGI:MGI:3035842 PMID:14992727^[6]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0030097	hemopoiesis	MGI:MGI:3616364 PMID:16415155^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158697	P	From MGI
	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O00255	P	From MGI
	GO:0030674	protein binding, bridging	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O00255	F	From MGI
	GO:0031062	positive regulation of histone methylation	MGI:MGI:3607663 PMID:16195383^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3608952	P	From MGI
	GO:0031062	positive regulation of histone methylation	MGI:MGI:3616364 PMID:16415155^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158697	P	From MGI
	GO:0032092	positive regulation of protein binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O00255	P	From MGI
	GO:0032154	cleavage furrow	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O00255	C	From MGI
	GO:0032925	regulation of activin receptor signaling pathway	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_062081	P	From MGI
	GO:0034968	histone lysine methylation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O00255	P	From MGI
	GO:0035097	histone methyltransferase complex	MGI:MGI:3035842 PMID:14992727^[6]	ISO: Inferred from Sequence Orthology	UniProtKB:O00255	C	From MGI
	GO:0035097	histone methyltransferase complex	MGI:MGI:3718866 PMID:17500065^[13]	ISO: Inferred from Sequence Orthology	UniProtKB:O00255	C	From MGI
	GO:0043065	positive regulation of apoptotic process	MGI:MGI:3037372 PMID:14688275^[20]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0043065	positive regulation of apoptotic process	MGI:MGI:3037372 PMID:14688275^[20]	IGI: Inferred from Genetic Interaction	MGI:MGI:99702 MGI:MGI:1097161	P	From MGI
	GO:0043234	protein complex	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O00255	C	From MGI
	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	MGI:MGI:3037372 PMID:14688275^[20]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O00255	P	From MGI
	GO:0043565	sequence-specific DNA binding	MGI:MGI:4838928 PMID:20956546^[21]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0044212	transcription regulatory region DNA binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O00255	F	From MGI
	GO:0045597	positive regulation of cell differentiation	MGI:MGI:3763871 PMID:17927973^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2683274 MGI:MGI:3573783	P	From MGI
	GO:0045668	negative regulation of osteoblast differentiation	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:O00255	P	From MGI
	GO:0045668	negative regulation of osteoblast differentiation	MGI:MGI:3056877 PMID:15150273^[4]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045668	negative regulation of osteoblast differentiation	MGI:MGI:3573815 PMID:15563473^[5]	IGI: Inferred from Genetic Interaction	MGI:MGI:96648	P	From MGI
	GO:0045669	positive regulation of osteoblast differentiation	MGI:MGI:3056877 PMID:15150273^[4]	IGI: Inferred from Genetic Interaction	MGI:MGI:88177	P	From MGI
	GO:0045736	negative regulation of cyclin-dependent protein kinase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O00255	P	From MGI
	GO:0045786	negative regulation of cell cycle	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O00255	P	From MGI
	GO:0045892	negative regulation of transcription, DNA-dependent	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O00255	P	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:3035842 PMID:14992727^[6]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:3056877 PMID:15150273^[4]	IGI: Inferred from Genetic Interaction	MGI:MGI:99829 MGI:MGI:1201674	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:3529753 PMID:15640349^[7]	IGI: Inferred from Genetic Interaction	MGI:MGI:96995	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:3607663 PMID:16195383^[8]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:3616364 PMID:16415155^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158697	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:4838928 PMID:20956546^[21]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158698	P	From MGI
	GO:0046329	negative regulation of JNK cascade	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O00255	P	From MGI
	GO:0046621	negative regulation of organ growth	MGI:MGI:3763020 PMID:17975067^[19]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0047485	protein N-terminus binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O00255	F	From MGI
	GO:0048704	embryonic skeletal system morphogenesis	MGI:MGI:3763871 PMID:17927973^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2683274 MGI:MGI:3573783	P	From MGI
	GO:0051781	positive regulation of cell division	MGI:MGI:3607663 PMID:16195383^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3608952	P	From MGI
	GO:0051781	positive regulation of cell division	MGI:MGI:3639378 PMID:16740708^[14]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158697 MGI:MGI:3663673	P	From MGI
	GO:0051974	negative regulation of telomerase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O00255	P	From MGI
	GO:0060021	palate development	MGI:MGI:3763871 PMID:17927973^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2683274 MGI:MGI:3573783	P	From MGI
	GO:0060135	maternal process involved in female pregnancy	MGI:MGI:3763020 PMID:17975067^[19]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0070412	R-SMAD binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O00255	F	From MGI
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 La P et al. (2004) Tumor suppressor menin regulates expression of insulin-like growth factor binding protein 2. Endocrinology 145: 3443-50 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Engleka KA et al. (2007) Menin is required in cranial neural crest for palatogenesis and perinatal viability. Dev Biol 311: 524-37 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Chen YX et al. (2006) The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression. Proc Natl Acad Sci U S A 103: 1018-23 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Sowa H et al. (2004) Menin is required for bone morphogenetic protein 2- and transforming growth factor beta-regulated osteoblastic differentiation through interaction with Smads and Runx2. J Biol Chem 279: 40267-75 PubMed GONUTS page
↑ ^5.0 ^5.1 Naito J et al. (2005) Menin suppresses osteoblast differentiation by antagonizing the AP-1 factor, JunD. J Biol Chem 280: 4785-91 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Hughes CM et al. (2004) Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus. Mol Cell 13: 587-97 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Milne TA et al. (2005) Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors. Proc Natl Acad Sci U S A 102: 749-54 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 Karnik SK et al. (2005) Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4c. Proc Natl Acad Sci U S A 102: 14659-64 PubMed GONUTS page
↑ Terranova R et al. (2006) Histone and DNA methylation defects at Hox genes in mice expressing a SET domain-truncated form of Mll. Proc Natl Acad Sci U S A 103: 6629-34 PubMed GONUTS page
↑ ^10.0 ^10.1 Stewart C et al. (1998) Characterization of the mouse Men1 gene and its expression during development. Oncogene 17: 2485-93 PubMed GONUTS page
↑ ^11.0 ^11.1 Bertolino P et al. (2003) Pancreatic beta-cell-specific ablation of the multiple endocrine neoplasia type 1 (MEN1) gene causes full penetrance of insulinoma development in mice. Cancer Res 63: 4836-41 PubMed GONUTS page
↑ Loffler KA et al. (2007) Broad tumor spectrum in a mouse model of multiple endocrine neoplasia type 1. Int J Cancer 120: 259-67 PubMed GONUTS page
↑ ^13.0 ^13.1 Cho YW et al. (2007) PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex. J Biol Chem 282: 20395-406 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Schnepp RW et al. (2006) Mutation of tumor suppressor gene Men1 acutely enhances proliferation of pancreatic islet cells. Cancer Res 66: 5707-15 PubMed GONUTS page
↑ ^15.0 ^15.1 Crabtree JS et al. (2001) A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumors. Proc Natl Acad Sci U S A 98: 1118-23 PubMed GONUTS page
↑ Libutti SK et al. (2003) Parathyroid gland-specific deletion of the mouse Men1 gene results in parathyroid neoplasia and hypercalcemic hyperparathyroidism. Cancer Res 63: 8022-8 PubMed GONUTS page
↑ Biondi CA et al. (2004) Conditional inactivation of the MEN1 gene leads to pancreatic and pituitary tumorigenesis but does not affect normal development of these tissues. Mol Cell Biol 24: 3125-31 PubMed GONUTS page
↑ Pei XH et al. (2007) p18Ink4c collaborates with Men1 to constrain lung stem cell expansion and suppress non-small-cell lung cancers. Cancer Res 67: 3162-70 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 Karnik SK et al. (2007) Menin controls growth of pancreatic beta-cells in pregnant mice and promotes gestational diabetes mellitus. Science 318: 806-9 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 Schnepp RW et al. (2004) Menin induces apoptosis in murine embryonic fibroblasts. J Biol Chem 279: 10685-91 PubMed GONUTS page
↑ ^21.0 ^21.1 Onodera A et al. (2010) STAT6-mediated displacement of polycomb by trithorax complex establishes long-term maintenance of GATA3 expression in T helper type 2 cells. J Exp Med 207: 2493-506 PubMed GONUTS page

[PMID:15044367-0] 1.0 ^1.1 ^1.2 La P et al. (2004) Tumor suppressor menin regulates expression of insulin-like growth factor binding protein 2. Endocrinology 145: 3443-50 PubMed GONUTS page

[PMID:17927973-1] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Engleka KA et al. (2007) Menin is required in cranial neural crest for palatogenesis and perinatal viability. Dev Biol 311: 524-37 PubMed GONUTS page

[PMID:16415155-2] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Chen YX et al. (2006) The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression. Proc Natl Acad Sci U S A 103: 1018-23 PubMed GONUTS page

[PMID:15150273-3] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Sowa H et al. (2004) Menin is required for bone morphogenetic protein 2- and transforming growth factor beta-regulated osteoblastic differentiation through interaction with Smads and Runx2. J Biol Chem 279: 40267-75 PubMed GONUTS page

[PMID:15563473-4] 5.0 ^5.1 Naito J et al. (2005) Menin suppresses osteoblast differentiation by antagonizing the AP-1 factor, JunD. J Biol Chem 280: 4785-91 PubMed GONUTS page

[PMID:14992727-5] 6.0 ^6.1 ^6.2 ^6.3 Hughes CM et al. (2004) Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus. Mol Cell 13: 587-97 PubMed GONUTS page

[PMID:15640349-6] 7.0 ^7.1 ^7.2 Milne TA et al. (2005) Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors. Proc Natl Acad Sci U S A 102: 749-54 PubMed GONUTS page

[PMID:16195383-7] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 Karnik SK et al. (2005) Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4c. Proc Natl Acad Sci U S A 102: 14659-64 PubMed GONUTS page

[PMID:16618927-8] Terranova R et al. (2006) Histone and DNA methylation defects at Hox genes in mice expressing a SET domain-truncated form of Mll. Proc Natl Acad Sci U S A 103: 6629-34 PubMed GONUTS page

[PMID:9824159-9] 10.0 ^10.1 Stewart C et al. (1998) Characterization of the mouse Men1 gene and its expression during development. Oncogene 17: 2485-93 PubMed GONUTS page

[PMID:12941803-10] 11.0 ^11.1 Bertolino P et al. (2003) Pancreatic beta-cell-specific ablation of the multiple endocrine neoplasia type 1 (MEN1) gene causes full penetrance of insulinoma development in mice. Cancer Res 63: 4836-41 PubMed GONUTS page

[PMID:17044021-11] Loffler KA et al. (2007) Broad tumor spectrum in a mouse model of multiple endocrine neoplasia type 1. Int J Cancer 120: 259-67 PubMed GONUTS page

[PMID:17500065-12] 13.0 ^13.1 Cho YW et al. (2007) PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex. J Biol Chem 282: 20395-406 PubMed GONUTS page

[PMID:16740708-13] 14.0 ^14.1 ^14.2 Schnepp RW et al. (2006) Mutation of tumor suppressor gene Men1 acutely enhances proliferation of pancreatic islet cells. Cancer Res 66: 5707-15 PubMed GONUTS page

[PMID:11158604-14] 15.0 ^15.1 Crabtree JS et al. (2001) A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumors. Proc Natl Acad Sci U S A 98: 1118-23 PubMed GONUTS page

[PMID:14633735-15] Libutti SK et al. (2003) Parathyroid gland-specific deletion of the mouse Men1 gene results in parathyroid neoplasia and hypercalcemic hyperparathyroidism. Cancer Res 63: 8022-8 PubMed GONUTS page

[PMID:15060136-16] Biondi CA et al. (2004) Conditional inactivation of the MEN1 gene leads to pancreatic and pituitary tumorigenesis but does not affect normal development of these tissues. Mol Cell Biol 24: 3125-31 PubMed GONUTS page

[PMID:17409423-17] Pei XH et al. (2007) p18Ink4c collaborates with Men1 to constrain lung stem cell expansion and suppress non-small-cell lung cancers. Cancer Res 67: 3162-70 PubMed GONUTS page

[PMID:17975067-18] 19.0 ^19.1 ^19.2 Karnik SK et al. (2007) Menin controls growth of pancreatic beta-cells in pregnant mice and promotes gestational diabetes mellitus. Science 318: 806-9 PubMed GONUTS page

[PMID:14688275-19] 20.0 ^20.1 ^20.2 Schnepp RW et al. (2004) Menin induces apoptosis in murine embryonic fibroblasts. J Biol Chem 279: 10685-91 PubMed GONUTS page

[PMID:20956546-20] 21.0 ^21.1 Onodera A et al. (2010) STAT6-mediated displacement of polycomb by trithorax complex establishes long-term maintenance of GATA3 expression in T helper type 2 cells. J Exp Med 207: 2493-506 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

[18]

[19]

[20]

[21]

Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Men1 ( synonyms: menin )
Protein Name(s)	multiple endocrine neoplasia 1,
External Links
MGI	MGI:1316736

MGI:Men1

Contents

Annotations

Notes

References

a

b

c

d

e

f

g

h

h cont.

l

m

n

o

p

p cont.

r

s

t

v

y

Personal tools

Namespaces

Variants

Views

Actions

Search

Navigation

Cacao

Journal Clubs

page contributors

Toolbox