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MGI:Melk
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Melk ( synonyms: MPK38 ) | |
| Protein Name(s) | maternal embryonic leucine zipper kinase, | |
| External Links | ||
| MGI | MGI:106924 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000166 |
nucleotide binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0547 |
F |
From MGI |
||
| GO:0004672 |
protein kinase activity |
MGI:MGI:1326761 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004674 |
protein serine/threonine kinase activity |
MGI:MGI:1326761 |
ISS: Inferred from Sequence or Structural Similarity |
F |
From MGI |
|||
| GO:0004674 |
protein serine/threonine kinase activity |
MGI:MGI:3829088 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004674 |
protein serine/threonine kinase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0004674 |
protein serine/threonine kinase activity |
MGI:MGI:87381 |
ISA: Inferred from Sequence Alignment |
EMBL:Z17205 |
F |
From MGI |
||
| GO:0004715 |
non-membrane spanning protein tyrosine kinase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005509 |
calcium ion binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3829088 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005524 |
ATP binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0067 |
F |
From MGI |
||
| GO:0005524 |
ATP binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
InterPro:IPR001772 |
F |
From MGI |
||
| GO:0005737 |
cytoplasm |
MGI:MGI:1342111 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005938 |
cell cortex |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006915 |
apoptotic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007049 |
cell cycle |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0131 |
P |
From MGI |
||
| GO:0008283 |
cell proliferation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0008289 |
lipid binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0446 |
F |
From MGI |
||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016301 |
kinase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0418 |
F |
From MGI |
||
| GO:0016310 |
phosphorylation |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0418 |
P |
From MGI |
||
| GO:0016740 |
transferase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0808 |
F |
From MGI |
||
| GO:0016772 |
transferase activity, transferring phosphorus-containing groups |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0043065 |
positive regulation of apoptotic process |
MGI:MGI:3829088 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0046777 |
protein autophosphorylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0061351 |
neural precursor cell proliferation |
MGI:MGI:5285180 |
IDA: Inferred from Direct Assay |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Gil M et al. (1997) Cloning and expression of a cDNA encoding a novel protein serine/threonine kinase predominantly expressed in hematopoietic cells. Gene 195: 295-301 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Jung H et al. (2008) Murine protein serine/threonine kinase 38 activates apoptosis signal-regulating kinase 1 via Thr 838 phosphorylation. J Biol Chem 283: 34541-53 PubMed GONUTS page
- ↑ Heyer BS et al. (1997) New member of the Snf1/AMPK kinase family, Melk, is expressed in the mouse egg and preimplantation embryo. Mol Reprod Dev 47: 148-56 PubMed GONUTS page
- ↑ Heyer BS et al. (1999) Expression of Melk, a new protein kinase, during early mouse development. Dev Dyn 215: 344-51 PubMed GONUTS page
- ↑ Nakano I et al. (2005) Maternal embryonic leucine zipper kinase (MELK) regulates multipotent neural progenitor proliferation. J Cell Biol 170: 413-27 PubMed GONUTS page
