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MGI:Meis1
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Meis1 | |
| Protein Name(s) | Meis homeobox 1, | |
| External Links | ||
| MGI | MGI:104717 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001525 |
angiogenesis |
MGI:MGI:3028436 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3029063 |
P |
From MGI |
||
| GO:0002089 |
lens morphogenesis in camera-type eye |
MGI:MGI:3028436 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3029063 |
P |
From MGI |
||
| GO:0003677 |
DNA binding |
MGI:MGI:1096952 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:1098387 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:1101739 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:2384485 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:3056028 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:3697248 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003682 |
chromatin binding |
MGI:MGI:3840762 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0003705 |
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity |
MGI:MGI:1339526 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:1096952 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:1339526 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3505657 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3527920 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3697248 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:1096952 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:1860574 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:3527920 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:3700620 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:3703117 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4848231 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005667 |
transcription factor complex |
MGI:MGI:1098387 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005667 |
transcription factor complex |
MGI:MGI:1101739 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005667 |
transcription factor complex |
MGI:MGI:1339526 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005667 |
transcription factor complex |
MGI:MGI:2384485 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0006351 |
transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0804 |
P |
From MGI |
||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:2384485 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006357 |
regulation of transcription from RNA polymerase II promoter |
MGI:MGI:1339526 |
IC: Inferred by Curator |
GO:0003705 |
P |
From MGI |
||
| GO:0006357 |
regulation of transcription from RNA polymerase II promoter |
MGI:MGI:1339526 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007275 |
multicellular organismal development |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0217 |
P |
From MGI |
||
| GO:0030097 |
hemopoiesis |
MGI:MGI:3028436 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3029063 |
P |
From MGI |
||
| GO:0043565 |
sequence-specific DNA binding |
MGI:MGI:3525808 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0043565 |
sequence-specific DNA binding |
MGI:MGI:3703117 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:97495 |
F |
From MGI |
||
| GO:0045665 |
negative regulation of neuron differentiation |
MGI:MGI:3772753 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:96174 |
P |
From MGI |
||
| GO:0046982 |
protein heterodimerization activity |
MGI:MGI:1098387 |
IPI: Inferred from Physical Interaction |
UniProtKB:P09631 |
F |
From MGI |
||
| GO:0046982 |
protein heterodimerization activity |
MGI:MGI:1101739 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0048514 |
blood vessel morphogenesis |
MGI:MGI:3577821 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3578637 |
P |
From MGI |
||
| GO:0060216 |
definitive hemopoiesis |
MGI:MGI:3577821 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3578637 |
P |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Hisa T et al. (2004) Hematopoietic, angiogenic and eye defects in Meis1 mutant animals. EMBO J 23: 450-9 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Chang CP et al. (1997) Meis proteins are major in vivo DNA binding partners for wild-type but not chimeric Pbx proteins. Mol Cell Biol 17: 5679-87 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Shen WF et al. (1997) AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins. Mol Cell Biol 17: 6448-58 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Knoepfler PS et al. (1997) Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1. Proc Natl Acad Sci U S A 94: 14553-8 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Zhang X et al. (2002) Meis homeoproteins directly regulate Pax6 during vertebrate lens morphogenesis. Genes Dev 16: 2097-107 PubMed GONUTS page
- ↑ Pruitt SC et al. (2004) Hox/Pbx and Brn binding sites mediate Pax3 expression in vitro and in vivo. Gene Expr Patterns 4: 671-85 PubMed GONUTS page
- ↑ 7.0 7.1 Deramaudt TB et al. (2006) The PDX1 homeodomain transcription factor negatively regulates the pancreatic ductal cell-specific keratin 19 promoter. J Biol Chem 281: 38385-95 PubMed GONUTS page
- ↑ Sohl M et al. (2009) Characterization of the murine Ephrin-B2 promoter. Gene 437: 54-9 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 9.3 9.4 Jacobs Y et al. (1999) Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity. Mol Cell Biol 19: 5134-42 PubMed GONUTS page
- ↑ Rhee JW et al. (2004) Pbx3 deficiency results in central hypoventilation. Am J Pathol 165: 1343-50 PubMed GONUTS page
- ↑ 11.0 11.1 Williams TM et al. (2005) Range of HOX/TALE superclass associations and protein domain requirements for HOXA13:MEIS interaction. Dev Biol 277: 457-71 PubMed GONUTS page
- ↑ Toresson H et al. (2000) Expression of Meis and Pbx genes and their protein products in the developing telencephalon: implications for regional differentiation. Mech Dev 94: 183-7 PubMed GONUTS page
- ↑ Shim S et al. (2007) Regulation of EphA8 gene expression by TALE homeobox transcription factors during development of the mesencephalon. Mol Cell Biol 27: 1614-30 PubMed GONUTS page
- ↑ 14.0 14.1 Zhang X et al. (2006) Pax6 is regulated by Meis and Pbx homeoproteins during pancreatic development. Dev Biol 300: 748-57 PubMed GONUTS page
- ↑ Liu J et al. (2010) Three-amino-acid-loop-extension homeodomain factor Meis3 regulates cell survival via PDK1. Proc Natl Acad Sci U S A 107: 20494-9 PubMed GONUTS page
- ↑ Kutejova E et al. (2005) Hoxa2 downregulates Six2 in the neural crest-derived mesenchyme. Development 132: 469-78 PubMed GONUTS page
- ↑ Yang X et al. (2008) Altered neuronal lineages in the facial ganglia of Hoxa2 mutant mice. Dev Biol 314: 171-88 PubMed GONUTS page
- ↑ 18.0 18.1 Azcoitia V et al. (2005) The homeodomain protein Meis1 is essential for definitive hematopoiesis and vascular patterning in the mouse embryo. Dev Biol 280: 307-20 PubMed GONUTS page
