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MGI:Mef2d
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Mef2d | |
| Protein Name(s) | myocyte enhancer factor 2D, | |
| External Links | ||
| MGI | MGI:99533 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000977 |
RNA polymerase II regulatory region sequence-specific DNA binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0000981 |
sequence-specific DNA binding RNA polymerase II transcription factor activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0001649 |
osteoblast differentiation |
MGI:MGI:3701381 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:99458 |
P |
From MGI |
||
| GO:0001958 |
endochondral ossification |
MGI:MGI:3701381 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:99458 |
P |
From MGI |
||
| GO:0002062 |
chondrocyte differentiation |
MGI:MGI:3701381 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:99458 |
P |
From MGI |
||
| GO:0003677 |
DNA binding |
MGI:MGI:3522543 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
MGI:MGI:2183076 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:2183076 |
IC: Inferred by Curator |
GO:0003700 |
C |
From MGI |
||
| GO:0005634 |
nucleus |
MGI:MGI:3041060 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:3522543 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006351 |
transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0804 |
P |
From MGI |
||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:2183076 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006366 |
transcription from RNA polymerase II promoter |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006915 |
apoptotic process |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0053 |
P |
From MGI |
||
| GO:0007275 |
multicellular organismal development |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0217 |
P |
From MGI |
||
| GO:0007399 |
nervous system development |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0524 |
P |
From MGI |
||
| GO:0019899 |
enzyme binding |
MGI:MGI:4838688 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0030154 |
cell differentiation |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0221 |
P |
From MGI |
||
| GO:0033613 |
activating transcription factor binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0042803 |
protein homodimerization activity |
MGI:MGI:5142393 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0042826 |
histone deacetylase binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0043231 |
intracellular membrane-bounded organelle |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
MGI:MGI:1289810 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3768839 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:99458 |
P |
From MGI |
||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4819086 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:97276 |
P |
From MGI |
||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:83748 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:96919 |
P |
From MGI |
||
| GO:0046982 |
protein heterodimerization activity |
MGI:MGI:5142393 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0046983 |
protein dimerization activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Arnold MA et al. (2007) MEF2C transcription factor controls chondrocyte hypertrophy and bone development. Dev Cell 12: 377-89 PubMed GONUTS page
- ↑ 2.0 2.1 Lemonnier M & Buckingham ME (2004) Characterization of a cardiac-specific enhancer, which directs {alpha}-cardiac actin gene transcription in the mouse adult heart. J Biol Chem 279: 55651-8 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Lazaro JB et al. (2002) Cyclin D-cdk4 activity modulates the subnuclear localization and interaction of MEF2 with SRC-family coactivators during skeletal muscle differentiation. Genes Dev 16: 1792-805 PubMed GONUTS page
- ↑ Molinari S et al. (2004) A novel complex regulates cardiac actin gene expression through interaction of Emb, a class VI POU domain protein, MEF2D, and the histone transacetylase p300. Mol Cell Biol 24: 2944-57 PubMed GONUTS page
- ↑ Choi J et al. (2010) Histone demethylase LSD1 is required to induce skeletal muscle differentiation by regulating myogenic factors. Biochem Biophys Res Commun 401: 327-32 PubMed GONUTS page
- ↑ 6.0 6.1 Zhao M et al. (1999) Regulation of the MEF2 family of transcription factors by p38. Mol Cell Biol 19: 21-30 PubMed GONUTS page
- ↑ Di Lisi R et al. (1998) Combinatorial cis-acting elements control tissue-specific activation of the cardiac troponin I gene in vitro and in vivo. J Biol Chem 273: 25371-80 PubMed GONUTS page
- ↑ Liu N et al. (2007) An intragenic MEF2-dependent enhancer directs muscle-specific expression of microRNAs 1 and 133. Proc Natl Acad Sci U S A 104: 20844-9 PubMed GONUTS page
- ↑ Jung SY & Ko YG (2010) TRIM72, a novel negative feedback regulator of myogenesis, is transcriptionally activated by the synergism of MyoD (or myogenin) and MEF2. Biochem Biophys Res Commun 396: 238-45 PubMed GONUTS page
- ↑ Black BL et al. (1996) Cooperative transcriptional activation by the neurogenic basic helix-loop-helix protein MASH1 and members of the myocyte enhancer factor-2 (MEF2) family. J Biol Chem 271: 26659-63 PubMed GONUTS page
