MGI:Med1

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	MGI:MGI:5297786 PMID:16723356^[1]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0000785	chromatin	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_001127833	C	From MGI
	GO:0000902	cell morphogenesis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15648	P	From MGI
	GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_001127833	F	From MGI
	GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	MGI:MGI:5297786 PMID:16723356^[1]	IMP: Inferred from Mutant Phenotype		F	From MGI
	GO:0001047	core promoter binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15648	F	From MGI
	GO:0001104	RNA polymerase II transcription cofactor activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_001127833	F	From MGI
	GO:0001104	RNA polymerase II transcription cofactor activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15648	F	From MGI
	GO:0001525	angiogenesis	MGI:MGI:2158098 PMID:11724781^[2]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0001701	in utero embryonic development	MGI:MGI:2682174 PMID:14500757^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2684189	P	From MGI
	GO:0001889	liver development	MGI:MGI:2682174 PMID:14500757^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2684189	P	From MGI
	GO:0001892	embryonic placenta development	MGI:MGI:2682174 PMID:14500757^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2684189	P	From MGI
	GO:0002088	lens development in camera-type eye	MGI:MGI:2158098 PMID:11724781^[2]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0002154	thyroid hormone mediated signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15648	P	From MGI
	GO:0003222	ventricular trabecula myocardium morphogenesis	MGI:MGI:2158098 PMID:11724781^[2]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0003406	retinal pigment epithelium development	MGI:MGI:2158098 PMID:11724781^[2]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0003677	DNA binding	MGI:MGI:3529655 PMID:15681609^[4]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003677	DNA binding	MGI:MGI:3806427 PMID:18722179^[5]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003682	chromatin binding	MGI:MGI:2446405 PMID:12446761^[6]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003682	chromatin binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15648	F	From MGI
	GO:0003712	transcription cofactor activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15648	F	From MGI
	GO:0003713	transcription coactivator activity	MGI:MGI:1097733 PMID:9325263^[7]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003713	transcription coactivator activity	MGI:MGI:1276677 PMID:9708794^[8]	TAS: Traceable Author Statement		F	From MGI
	GO:0003713	transcription coactivator activity	MGI:MGI:1355642 PMID:10882104^[9]	TAS: Traceable Author Statement		F	From MGI
	GO:0003713	transcription coactivator activity	MGI:MGI:1858663 PMID:10747854^[10]	TAS: Traceable Author Statement		F	From MGI
	GO:0003713	transcription coactivator activity	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:Q15648	F	From MGI
	GO:0003713	transcription coactivator activity	MGI:MGI:2158098 PMID:11724781^[2]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003713	transcription coactivator activity	MGI:MGI:3055270 PMID:15340084^[11]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0004872	receptor activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15648	F	From MGI
	GO:0005515	protein binding	MGI:MGI:1097733 PMID:9325263^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P23204 UniProtKB:P37238	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3798012 PMID:18339625^[12]	IPI: Inferred from Physical Interaction	UniProtKB:P28033	F	From MGI
	GO:0005515	protein binding	MGI:MGI:5297786 PMID:16723356^[1]	IPI: Inferred from Physical Interaction	UniProtKB:P11416	F	From MGI
	GO:0005634	nucleus	MGI:MGI:3511247 PMID:15150259^[13]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:3806427 PMID:18722179^[5]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_001127833	C	From MGI
	GO:0005634	nucleus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15648	C	From MGI
	GO:0005730	nucleolus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15648	C	From MGI
	GO:0006260	DNA replication	MGI:MGI:1355642 PMID:10882104^[9]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1861125	P	From MGI
	GO:0006351	transcription, DNA-dependent	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0804	P	From MGI
	GO:0006355	regulation of transcription, DNA-dependent	MGI:MGI:1097733 PMID:9325263^[7]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0006355	regulation of transcription, DNA-dependent	MGI:MGI:1276677 PMID:9708794^[8]	TAS: Traceable Author Statement		P	From MGI
	GO:0006355	regulation of transcription, DNA-dependent	MGI:MGI:1355642 PMID:10882104^[9]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1861125	P	From MGI
	GO:0006355	regulation of transcription, DNA-dependent	MGI:MGI:1858663 PMID:10747854^[10]	TAS: Traceable Author Statement		P	From MGI
	GO:0006356	regulation of transcription from RNA polymerase I promoter	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15648	P	From MGI
	GO:0006357	regulation of transcription from RNA polymerase II promoter	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR019680	P	From MGI
	GO:0006366	transcription from RNA polymerase II promoter	MGI:MGI:2182530 PMID:12093747^[14]	IC: Inferred by Curator	GO:0016592	P	From MGI
	GO:0006367	transcription initiation from RNA polymerase II promoter	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15648	P	From MGI
	GO:0006590	thyroid hormone generation	MGI:MGI:1355642 PMID:10882104^[9]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1861125	P	From MGI
	GO:0006702	androgen biosynthetic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15648	P	From MGI
	GO:0007275	multicellular organismal development	MGI:MGI:1355642 PMID:10882104^[9]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1861125	P	From MGI
	GO:0007420	brain development	MGI:MGI:1355642 PMID:10882104^[9]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1861125	P	From MGI
	GO:0007507	heart development	MGI:MGI:1355642 PMID:10882104^[9]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1861125	P	From MGI
	GO:0007595	lactation	MGI:MGI:3576991 PMID:15647257^[15]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3511276	P	From MGI
	GO:0008134	transcription factor binding	MGI:MGI:2158098 PMID:11724781^[2]	IPI: Inferred from Physical Interaction	UniProtKB:O09100 UniProtKB:P17678 UniProtKB:P17679 UniProtKB:P23772 UniProtKB:P23824 UniProtKB:P23825 UniProtKB:Q08369 UniProtKB:Q61169	F	From MGI
	GO:0008134	transcription factor binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15648	F	From MGI
	GO:0009887	organ morphogenesis	MGI:MGI:1858663 PMID:10747854^[10]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1861123	P	From MGI
	GO:0010628	positive regulation of gene expression	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15648	P	From MGI
	GO:0010839	negative regulation of keratinocyte proliferation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15648	P	From MGI
	GO:0016592	mediator complex	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:Q15648	C	From MGI
	GO:0016592	mediator complex	MGI:MGI:2182530 PMID:12093747^[14]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0016592	mediator complex	MGI:MGI:3033544 PMID:14638676^[16]	ISO: Inferred from Sequence Orthology	UniProtKB:Q15648	C	From MGI
	GO:0016592	mediator complex	MGI:MGI:3055270 PMID:15340084^[11]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0016922	ligand-dependent nuclear receptor binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15648	F	From MGI
	GO:0030216	keratinocyte differentiation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15648	P	From MGI
	GO:0030224	monocyte differentiation	MGI:MGI:3655015 PMID:16324150^[17]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1861125	P	From MGI
	GO:0030331	estrogen receptor binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15648	F	From MGI
	GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15648	F	From MGI
	GO:0030375	thyroid hormone receptor coactivator activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15648	F	From MGI
	GO:0030518	intracellular steroid hormone receptor signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15648	P	From MGI
	GO:0030521	androgen receptor signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15648	P	From MGI
	GO:0031100	organ regeneration	MGI:MGI:3719773 PMID:17438330^[18]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3511276 MGI:MGI:2176946	P	From MGI
	GO:0031490	chromatin DNA binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_001127833	F	From MGI
	GO:0032403	protein complex binding	MGI:MGI:3055270 PMID:15340084^[11]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0032403	protein complex binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_001127833	F	From MGI
	GO:0032993	protein-DNA complex	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_001127833	C	From MGI
	GO:0033148	positive regulation of intracellular estrogen receptor signaling pathway	MGI:MGI:4442276 PMID:20351249^[19]	IMP: Inferred from Mutant Phenotype	MGI:MGI:4443002	P	From MGI
	GO:0033160	positive regulation of protein import into nucleus, translocation	MGI:MGI:3653560 PMID:16828057^[20]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3511276 MGI:MGI:2176946	P	From MGI
	GO:0033160	positive regulation of protein import into nucleus, translocation	MGI:MGI:3768286 PMID:17962186^[21]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3511276 MGI:MGI:2176946	P	From MGI
	GO:0033598	mammary gland epithelial cell proliferation	MGI:MGI:4442276 PMID:20351249^[19]	IMP: Inferred from Mutant Phenotype	MGI:MGI:4443002	P	From MGI
	GO:0033601	positive regulation of mammary gland epithelial cell proliferation	MGI:MGI:3578445 PMID:15843544^[22]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3511276	P	From MGI
	GO:0035050	embryonic heart tube development	MGI:MGI:2682174 PMID:14500757^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2684189	P	From MGI
	GO:0035116	embryonic hindlimb morphogenesis	MGI:MGI:2682174 PMID:14500757^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2684189	P	From MGI
	GO:0035162	embryonic hemopoiesis	MGI:MGI:2682174 PMID:14500757^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2684189	P	From MGI
	GO:0035257	nuclear hormone receptor binding	MGI:MGI:1097733 PMID:9325263^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P11416	F	From MGI
	GO:0035357	peroxisome proliferator activated receptor signaling pathway	MGI:MGI:3511247 PMID:15150259^[13]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3511276 MGI:MGI:2176946	P	From MGI
	GO:0035729	cellular response to hepatocyte growth factor stimulus	MGI:MGI:3719773 PMID:17438330^[18]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3511276 MGI:MGI:2176946	P	From MGI
	GO:0035855	megakaryocyte development	MGI:MGI:2158098 PMID:11724781^[2]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0036033	mediator complex binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15648	F	From MGI
	GO:0042789	mRNA transcription from RNA polymerase II promoter	MGI:MGI:5297786 PMID:16723356^[1]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0042809	vitamin D receptor binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_001127833	F	From MGI
	GO:0042809	vitamin D receptor binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15648	F	From MGI
	GO:0042974	retinoic acid receptor binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15648	F	From MGI
	GO:0042975	peroxisome proliferator activated receptor binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15648	F	From MGI
	GO:0043010	camera-type eye development	MGI:MGI:2682174 PMID:14500757^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2684189	P	From MGI
	GO:0043066	negative regulation of apoptotic process	MGI:MGI:5297786 PMID:16723356^[1]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0045444	fat cell differentiation	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:Q15648	P	From MGI
	GO:0045444	fat cell differentiation	MGI:MGI:2180395 PMID:12037571^[23]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1861125	P	From MGI
	GO:0045618	positive regulation of keratinocyte differentiation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15648	P	From MGI
	GO:0045665	negative regulation of neuron differentiation	MGI:MGI:5297786 PMID:16723356^[1]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15648	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:Q15648	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:2158098 PMID:11724781^[2]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:3055270 PMID:15340084^[11]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_001127833	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:5004792 PMID:17827210^[24]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0046966	thyroid hormone receptor binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_001127833	F	From MGI
	GO:0046966	thyroid hormone receptor binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15648	F	From MGI
	GO:0048821	erythrocyte development	MGI:MGI:2158098 PMID:11724781^[2]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0048821	erythrocyte development	MGI:MGI:3699072 PMID:17132730^[25]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1861125	P	From MGI
	GO:0048822	enucleate erythrocyte development	MGI:MGI:4867338 PMID:21098667^[26]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3511276 MGI:MGI:2176073	P	From MGI
	GO:0050693	LBD domain binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15648	F	From MGI
	GO:0060335	positive regulation of interferon-gamma-mediated signaling pathway	MGI:MGI:3798012 PMID:18339625^[12]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3511276 MGI:MGI:2176946	P	From MGI
	GO:0060744	mammary gland branching involved in thelarche	MGI:MGI:3576991 PMID:15647257^[15]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3511276	P	From MGI
	GO:0060745	mammary gland branching involved in pregnancy	MGI:MGI:3576991 PMID:15647257^[15]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3511276	P	From MGI
	GO:0060750	epithelial cell proliferation involved in mammary gland duct elongation	MGI:MGI:3576991 PMID:15647257^[15]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3511276	P	From MGI
	GO:0070318	positive regulation of G0 to G1 transition	MGI:MGI:3719773 PMID:17438330^[18]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3511276 MGI:MGI:2176946	P	From MGI
	GO:0070371	ERK1 and ERK2 cascade	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15648	P	From MGI
	GO:0070562	regulation of vitamin D receptor signaling pathway	MGI:MGI:3655015 PMID:16324150^[17]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1861125	P	From MGI
	GO:0071364	cellular response to epidermal growth factor stimulus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15648	P	From MGI
	GO:0071383	cellular response to steroid hormone stimulus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15648	P	From MGI
	GO:0097067	cellular response to thyroid hormone stimulus	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_001127833	P	From MGI
	GO:0097067	cellular response to thyroid hormone stimulus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15648	P	From MGI
	GO:2000273	positive regulation of receptor activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15648	P	From MGI
	GO:2000347	positive regulation of hepatocyte proliferation	MGI:MGI:3719773 PMID:17438330^[18]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3511276 MGI:MGI:2176946	P	From MGI
	GO:2001141	regulation of RNA biosynthetic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q15648	P	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Flajollet S et al. (2006) Distinct roles of the steroid receptor coactivator 1 and of MED1 in retinoid-induced transcription and cellular differentiation. J Biol Chem 281: 20338-48 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 Crawford SE et al. (2002) Defects of the heart, eye, and megakaryocytes in peroxisome proliferator activator receptor-binding protein (PBP) null embryos implicate GATA family of transcription factors. J Biol Chem 277: 3585-92 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Landles C et al. (2003) The thyroid hormone receptor-associated protein TRAP220 is required at distinct embryonic stages in placental, cardiac, and hepatic development. Mol Endocrinol 17: 2418-35 PubMed GONUTS page
↑ Guan HP et al. (2005) Corepressors selectively control the transcriptional activity of PPARgamma in adipocytes. Genes Dev 19: 453-61 PubMed GONUTS page
↑ ^5.0 ^5.1 Tatarakis A et al. (2008) Dominant and redundant functions of TFIID involved in the regulation of hepatic genes. Mol Cell 31: 531-43 PubMed GONUTS page
↑ Kim SW et al. (2002) Multiple developmental defects derived from impaired recruitment of ASC-2 to nuclear receptors in mice: implication for posterior lenticonus with cataract. Mol Cell Biol 22: 8409-14 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Zhu Y et al. (1997) Isolation and characterization of PBP, a protein that interacts with peroxisome proliferator-activated receptor. J Biol Chem 272: 25500-6 PubMed GONUTS page
↑ ^8.0 ^8.1 Jain S et al. (1998) Differential expression of the peroxisome proliferator-activated receptor gamma (PPARgamma) and its coactivators steroid receptor coactivator-1 and PPAR-binding protein PBP in the brown fat, urinary bladder, colon, and breast of the mouse. Am J Pathol 153: 349-54 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 Ito M et al. (2000) Involvement of the TRAP220 component of the TRAP/SMCC coactivator complex in embryonic development and thyroid hormone action. Mol Cell 5: 683-93 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Zhu Y et al. (2000) Deletion of PBP/PPARBP, the gene for nuclear receptor coactivator peroxisome proliferator-activated receptor-binding protein, results in embryonic lethality. J Biol Chem 275: 14779-82 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 Malik S et al. (2004) Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors. Mol Cell Biol 24: 8244-54 PubMed GONUTS page
↑ ^12.0 ^12.1 Li H et al. (2008) The Med1 subunit of transcriptional mediator plays a central role in regulating CCAAT/enhancer-binding protein-beta-driven transcription in response to interferon-gamma. J Biol Chem 283: 13077-86 PubMed GONUTS page
↑ ^13.0 ^13.1 Jia Y et al. (2004) Transcription coactivator PBP, the peroxisome proliferator-activated receptor (PPAR)-binding protein, is required for PPARalpha-regulated gene expression in liver. J Biol Chem 279: 24427-34 PubMed GONUTS page
↑ ^14.0 ^14.1 Ito M et al. (2002) The TRAP100 component of the TRAP/Mediator complex is essential in broad transcriptional events and development. EMBO J 21: 3464-75 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 Jia Y et al. (2005) Peroxisome proliferator-activated receptor-binding protein null mutation results in defective mammary gland development. J Biol Chem 280: 10766-73 PubMed GONUTS page
↑ Tomomori-Sato C et al. (2004) A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2. J Biol Chem 279: 5846-51 PubMed GONUTS page
↑ ^17.0 ^17.1 Urahama N et al. (2005) The role of transcriptional coactivator TRAP220 in myelomonocytic differentiation. Genes Cells 10: 1127-37 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 ^18.3 Matsumoto K et al. (2007) Critical role for transcription coactivator peroxisome proliferator-activated receptor (PPAR)-binding protein/TRAP220 in liver regeneration and PPARalpha ligand-induced liver tumor development. J Biol Chem 282: 17053-60 PubMed GONUTS page
↑ ^19.0 ^19.1 Jiang P et al. (2010) Key roles for MED1 LxxLL motifs in pubertal mammary gland development and luminal-cell differentiation. Proc Natl Acad Sci U S A 107: 6765-70 PubMed GONUTS page
↑ Guo D et al. (2006) Peroxisome proliferator-activated receptor (PPAR)-binding protein (PBP) but not PPAR-interacting protein (PRIP) is required for nuclear translocation of constitutive androstane receptor in mouse liver. Biochem Biophys Res Commun 347: 485-95 PubMed GONUTS page
↑ Guo D et al. (2007) Induction of nuclear translocation of constitutive androstane receptor by peroxisome proliferator-activated receptor alpha synthetic ligands in mouse liver. J Biol Chem 282: 36766-76 PubMed GONUTS page
↑ Meissner NN et al. (2005) Role of type I IFNs in pulmonary complications of Pneumocystis murina infection. J Immunol 174: 5462-71 PubMed GONUTS page
↑ Ge K et al. (2002) Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis. Nature 417: 563-7 PubMed GONUTS page
↑ Chen W & Roeder RG (2007) The Mediator subunit MED1/TRAP220 is required for optimal glucocorticoid receptor-mediated transcription activation. Nucleic Acids Res 35: 6161-9 PubMed GONUTS page
↑ Stumpf M et al. (2006) The mediator complex functions as a coactivator for GATA-1 in erythropoiesis via subunit Med1/TRAP220. Proc Natl Acad Sci U S A 103: 18504-9 PubMed GONUTS page
↑ Stumpf M et al. (2010) Specific erythroid-lineage defect in mice conditionally deficient for Mediator subunit Med1. Proc Natl Acad Sci U S A 107: 21541-6 PubMed GONUTS page

[PMID:16723356-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Flajollet S et al. (2006) Distinct roles of the steroid receptor coactivator 1 and of MED1 in retinoid-induced transcription and cellular differentiation. J Biol Chem 281: 20338-48 PubMed GONUTS page

[PMID:11724781-1] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 Crawford SE et al. (2002) Defects of the heart, eye, and megakaryocytes in peroxisome proliferator activator receptor-binding protein (PBP) null embryos implicate GATA family of transcription factors. J Biol Chem 277: 3585-92 PubMed GONUTS page

[PMID:14500757-2] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Landles C et al. (2003) The thyroid hormone receptor-associated protein TRAP220 is required at distinct embryonic stages in placental, cardiac, and hepatic development. Mol Endocrinol 17: 2418-35 PubMed GONUTS page

[PMID:15681609-3] Guan HP et al. (2005) Corepressors selectively control the transcriptional activity of PPARgamma in adipocytes. Genes Dev 19: 453-61 PubMed GONUTS page

[PMID:18722179-4] 5.0 ^5.1 Tatarakis A et al. (2008) Dominant and redundant functions of TFIID involved in the regulation of hepatic genes. Mol Cell 31: 531-43 PubMed GONUTS page

[PMID:12446761-5] Kim SW et al. (2002) Multiple developmental defects derived from impaired recruitment of ASC-2 to nuclear receptors in mice: implication for posterior lenticonus with cataract. Mol Cell Biol 22: 8409-14 PubMed GONUTS page

[PMID:9325263-6] 7.0 ^7.1 ^7.2 ^7.3 Zhu Y et al. (1997) Isolation and characterization of PBP, a protein that interacts with peroxisome proliferator-activated receptor. J Biol Chem 272: 25500-6 PubMed GONUTS page

[PMID:9708794-7] 8.0 ^8.1 Jain S et al. (1998) Differential expression of the peroxisome proliferator-activated receptor gamma (PPARgamma) and its coactivators steroid receptor coactivator-1 and PPAR-binding protein PBP in the brown fat, urinary bladder, colon, and breast of the mouse. Am J Pathol 153: 349-54 PubMed GONUTS page

[PMID:10882104-8] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 Ito M et al. (2000) Involvement of the TRAP220 component of the TRAP/SMCC coactivator complex in embryonic development and thyroid hormone action. Mol Cell 5: 683-93 PubMed GONUTS page

[PMID:10747854-9] 10.0 ^10.1 ^10.2 Zhu Y et al. (2000) Deletion of PBP/PPARBP, the gene for nuclear receptor coactivator peroxisome proliferator-activated receptor-binding protein, results in embryonic lethality. J Biol Chem 275: 14779-82 PubMed GONUTS page

[PMID:15340084-10] 11.0 ^11.1 ^11.2 ^11.3 Malik S et al. (2004) Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors. Mol Cell Biol 24: 8244-54 PubMed GONUTS page

[PMID:18339625-11] 12.0 ^12.1 Li H et al. (2008) The Med1 subunit of transcriptional mediator plays a central role in regulating CCAAT/enhancer-binding protein-beta-driven transcription in response to interferon-gamma. J Biol Chem 283: 13077-86 PubMed GONUTS page

[PMID:15150259-12] 13.0 ^13.1 Jia Y et al. (2004) Transcription coactivator PBP, the peroxisome proliferator-activated receptor (PPAR)-binding protein, is required for PPARalpha-regulated gene expression in liver. J Biol Chem 279: 24427-34 PubMed GONUTS page

[PMID:12093747-13] 14.0 ^14.1 Ito M et al. (2002) The TRAP100 component of the TRAP/Mediator complex is essential in broad transcriptional events and development. EMBO J 21: 3464-75 PubMed GONUTS page

[PMID:15647257-14] 15.0 ^15.1 ^15.2 ^15.3 Jia Y et al. (2005) Peroxisome proliferator-activated receptor-binding protein null mutation results in defective mammary gland development. J Biol Chem 280: 10766-73 PubMed GONUTS page

[PMID:14638676-15] Tomomori-Sato C et al. (2004) A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2. J Biol Chem 279: 5846-51 PubMed GONUTS page

[PMID:16324150-16] 17.0 ^17.1 Urahama N et al. (2005) The role of transcriptional coactivator TRAP220 in myelomonocytic differentiation. Genes Cells 10: 1127-37 PubMed GONUTS page

[PMID:17438330-17] 18.0 ^18.1 ^18.2 ^18.3 Matsumoto K et al. (2007) Critical role for transcription coactivator peroxisome proliferator-activated receptor (PPAR)-binding protein/TRAP220 in liver regeneration and PPARalpha ligand-induced liver tumor development. J Biol Chem 282: 17053-60 PubMed GONUTS page

[PMID:20351249-18] 19.0 ^19.1 Jiang P et al. (2010) Key roles for MED1 LxxLL motifs in pubertal mammary gland development and luminal-cell differentiation. Proc Natl Acad Sci U S A 107: 6765-70 PubMed GONUTS page

[PMID:16828057-19] Guo D et al. (2006) Peroxisome proliferator-activated receptor (PPAR)-binding protein (PBP) but not PPAR-interacting protein (PRIP) is required for nuclear translocation of constitutive androstane receptor in mouse liver. Biochem Biophys Res Commun 347: 485-95 PubMed GONUTS page

[PMID:17962186-20] Guo D et al. (2007) Induction of nuclear translocation of constitutive androstane receptor by peroxisome proliferator-activated receptor alpha synthetic ligands in mouse liver. J Biol Chem 282: 36766-76 PubMed GONUTS page

[PMID:15843544-21] Meissner NN et al. (2005) Role of type I IFNs in pulmonary complications of Pneumocystis murina infection. J Immunol 174: 5462-71 PubMed GONUTS page

[PMID:12037571-22] Ge K et al. (2002) Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis. Nature 417: 563-7 PubMed GONUTS page

[PMID:17827210-23] Chen W & Roeder RG (2007) The Mediator subunit MED1/TRAP220 is required for optimal glucocorticoid receptor-mediated transcription activation. Nucleic Acids Res 35: 6161-9 PubMed GONUTS page

[PMID:17132730-24] Stumpf M et al. (2006) The mediator complex functions as a coactivator for GATA-1 in erythropoiesis via subunit Med1/TRAP220. Proc Natl Acad Sci U S A 103: 18504-9 PubMed GONUTS page

[PMID:21098667-25] Stumpf M et al. (2010) Specific erythroid-lineage defect in mice conditionally deficient for Mediator subunit Med1. Proc Natl Acad Sci U S A 107: 21541-6 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Med1 ( synonyms: CRSP210, DRIP205, l11Jus15, PBP, Pparbp, TRAP 220, TRAP220 )
Protein Name(s)	mediator complex subunit 1,
External Links
MGI	MGI:1100846

MGI:Med1

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