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MGI:Mdk

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Contents

Species (Taxon ID) Mus musculus (house mouse) (taxon:10090)
Gene Name(s) Mdk ( synonyms: Mek, MK )
Protein Name(s) midkine,
External Links
MGI MGI:96949

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0001662

behavioral fear response

MGI:MGI:2178952
PMID:10096022[1]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0005576

extracellular region

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0964

C

From MGI

GO:0007275

multicellular organismal development

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0217

P

From MGI

GO:0007614

short-term memory

MGI:MGI:2178952
PMID:10096022[1]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0008083

growth factor activity

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0339

F

From MGI

GO:0008083

growth factor activity

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR000762
InterPro:IPR020090
InterPro:IPR020092
InterPro:IPR020091
InterPro:IPR020089

F

From MGI

GO:0008201

heparin binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P21741

F

From MGI

GO:0009611

response to wounding

MGI:MGI:1353777
PMID:10683378[2]

IDA: Inferred from Direct Assay

P

From MGI

GO:0009611

response to wounding

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_110486

P

From MGI

GO:0016477

cell migration

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_110486

P

From MGI

GO:0021681

cerebellar granular layer development

MGI:MGI:2178952
PMID:10096022[1]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0021766

hippocampus development

MGI:MGI:2178952
PMID:10096022[1]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0030154

cell differentiation

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0221

P

From MGI

GO:0030325

adrenal gland development

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_110486

P

From MGI

GO:0030421

defecation

MGI:MGI:2178952
PMID:10096022[1]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0043526

neuroprotection

MGI:MGI:4943836
PMID:20346117[3]

IDA: Inferred from Direct Assay

P

From MGI

GO:0045893

positive regulation of transcription, DNA-dependent

MGI:MGI:2178952
PMID:10096022[1]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0050795

regulation of behavior

MGI:MGI:2178952
PMID:10096022[1]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0051781

positive regulation of cell division

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0497

P

From MGI


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Nakamura E et al. (1998) Disruption of the midkine gene (Mdk) resulted in altered expression of a calcium binding protein in the hippocampus of infant mice and their abnormal behaviour. Genes Cells 3: 811-22 PubMed GONUTS page
  2. Horiba M et al. (2000) Neointima formation in a restenosis model is suppressed in midkine-deficient mice. J Clin Invest 105: 489-95 PubMed GONUTS page
  3. Kim YB et al. (2010) Midkine, heparin-binding growth factor, blocks kainic acid-induced seizure and neuronal cell death in mouse hippocampus. BMC Neurosci 11: 42 PubMed GONUTS page
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