GONUTS is under stress! The website is currently experiencing long-wait times and frequent time-outs due to the record number of students, groups, and annotations related to CACAO this semester. We are currently working on increasing performance -- please accept our apologies for the technical difficulties.
You can help reduce stress on the server by:
- not reloading pages frequently - this just adds
- opening links in new windows (so you can read the old page)
MGI:Mapt
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Mapt ( synonyms: Mtapt, Tau ) | |
| Protein Name(s) | microtubule-associated protein tau, | |
| External Links | ||
| MGI | MGI:97180 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000226 |
microtubule cytoskeleton organization |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0000226 |
microtubule cytoskeleton organization |
MGI:MGI:67243 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2138030 |
P |
From MGI |
||
| GO:0001764 |
neuron migration |
MGI:MGI:4361051 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2385630 |
P |
From MGI |
||
| GO:0005515 |
protein binding |
MGI:MGI:3820482 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3822720 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:3694279 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2385630 |
C |
From MGI |
||
| GO:0005622 |
intracellular |
MGI:MGI:4835593 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:88059 |
C |
From MGI |
||
| GO:0005634 |
nucleus |
MGI:MGI:4454362 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4454362 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005856 |
cytoskeleton |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0206 |
C |
From MGI |
||
| GO:0005874 |
microtubule |
MGI:MGI:3604278 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006915 |
apoptotic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007026 |
negative regulation of microtubule depolymerization |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0007409 |
axonogenesis |
MGI:MGI:3614337 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1306778 |
P |
From MGI |
||
| GO:0007584 |
response to nutrient |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007628 |
adult walking behavior |
MGI:MGI:3833162 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1097712 |
P |
From MGI |
||
| GO:0008017 |
microtubule binding |
MGI:MGI:3773602 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0008017 |
microtubule binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0008017 |
microtubule binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0008088 |
axon cargo transport |
MGI:MGI:4835593 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:88059 |
P |
From MGI |
||
| GO:0010033 |
response to organic substance |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0010506 |
regulation of autophagy |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0017124 |
SH3 domain binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0019899 |
enzyme binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0019899 |
enzyme binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0019901 |
protein kinase binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0019904 |
protein domain specific binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0030424 |
axon |
MGI:MGI:3577007 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0030424 |
axon |
MGI:MGI:3604278 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0030424 |
axon |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0030424 |
axon |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0030424 |
axon |
MGI:MGI:65949 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0030426 |
growth cone |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0031116 |
positive regulation of microtubule polymerization |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0032387 |
negative regulation of intracellular transport |
MGI:MGI:3694279 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2385630 |
P |
From MGI |
||
| GO:0034399 |
nuclear periphery |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0035085 |
cilium axoneme |
MGI:MGI:3821640 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0042995 |
cell projection |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0966 |
C |
From MGI |
||
| GO:0043005 |
neuron projection |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0044295 |
axonal growth cone |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0045298 |
tubulin complex |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0045773 |
positive regulation of axon extension |
MGI:MGI:3694279 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2385630 |
P |
From MGI |
||
| GO:0045773 |
positive regulation of axon extension |
MGI:MGI:4454362 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2385630 |
P |
From MGI |
||
| GO:0045773 |
positive regulation of axon extension |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0047497 |
mitochondrion transport along microtubule |
MGI:MGI:3694279 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2385630 |
P |
From MGI |
||
| GO:0048676 |
axon extension involved in development |
MGI:MGI:3614337 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0048676 |
axon extension involved in development |
MGI:MGI:3694279 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2385630 |
P |
From MGI |
||
| GO:0060632 |
regulation of microtubule-based movement |
MGI:MGI:3773602 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0071813 |
lipoprotein particle binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Harada A et al. (1994) Altered microtubule organization in small-calibre axons of mice lacking tau protein. Nature 369: 488-91 PubMed GONUTS page
- ↑ Fuster-Matanzo A et al. (2009) Function of tau protein in adult newborn neurons. FEBS Lett 583: 3063-8 PubMed GONUTS page
- ↑ Yu DY et al. (2008) Tau binds both subunits of calcineurin, and binding is impaired by calmodulin. Biochim Biophys Acta 1783: 2255-61 PubMed GONUTS page
- ↑ Sadik G et al. (2009) Phosphorylation of tau at Ser214 mediates its interaction with 14-3-3 protein: implications for the mechanism of tau aggregation. J Neurochem 108: 33-43 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 Jiménez-Mateos EM et al. (2006) Role of MAP1B in axonal retrograde transport of mitochondria. Biochem J 397: 53-9 PubMed GONUTS page
- ↑ 6.0 6.1 Vossel KA et al. (2010) Tau reduction prevents Abeta-induced defects in axonal transport. Science 330: 198 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 de Barreda EG et al. (2010) Tau deficiency leads to the upregulation of BAF-57, a protein involved in neuron-specific gene repression. FEBS Lett 584: 2265-70 PubMed GONUTS page
- ↑ 8.0 8.1 Fukami S et al. (2002) Abeta-degrading endopeptidase, neprilysin, in mouse brain: synaptic and axonal localization inversely correlating with Abeta pathology. Neurosci Res 43: 39-56 PubMed GONUTS page
- ↑ 9.0 9.1 González-Billault C et al. (2002) Participation of structural microtubule-associated proteins (MAPs) in the development of neuronal polarity. J Neurosci Res 67: 713-9 PubMed GONUTS page
- ↑ Pacheco CD et al. (2009) Tau deletion exacerbates the phenotype of Niemann-Pick type C mice and implicates autophagy in pathogenesis. Hum Mol Genet 18: 956-65 PubMed GONUTS page
- ↑ 11.0 11.1 Dixit R et al. (2008) Differential regulation of dynein and kinesin motor proteins by tau. Science 319: 1086-9 PubMed GONUTS page
- ↑ Bretin S et al. (2005) Differential expression of CRMP1, CRMP2A, CRMP2B, and CRMP5 in axons or dendrites of distinct neurons in the mouse brain. J Comp Neurol 486: 1-17 PubMed GONUTS page
- ↑ Brion JP et al. (1988) Dendritic and axonal distribution of the microtubule-associated proteins MAP2 and tau in the cerebellum of the nervous mutant mouse. Brain Res Dev Brain Res 44: 221-32 PubMed GONUTS page
- ↑ Hoover AN et al. (2008) C2cd3 is required for cilia formation and Hedgehog signaling in mouse. Development 135: 4049-58 PubMed GONUTS page
