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MGI:Mapkapk5
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Mapkapk5 ( synonyms: MK5, PRAK ) | |
| Protein Name(s) | MAP kinase-activated protein kinase 5, | |
| External Links | ||
| MGI | MGI:1333110 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000166 |
nucleotide binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0547 |
F |
From MGI |
||
| GO:0002039 |
p53 binding |
MGI:MGI:3697960 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0002039 |
p53 binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0004672 |
protein kinase activity |
MGI:MGI:3521520 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004674 |
protein serine/threonine kinase activity |
MGI:MGI:3697960 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004674 |
protein serine/threonine kinase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0004674 |
protein serine/threonine kinase activity |
MGI:MGI:5306302 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004674 |
protein serine/threonine kinase activity |
MGI:MGI:5306310 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004674 |
protein serine/threonine kinase activity |
MGI:MGI:5306547 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004674 |
protein serine/threonine kinase activity |
MGI:MGI:5306555 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:5306547 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005524 |
ATP binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0067 |
F |
From MGI |
||
| GO:0005524 |
ATP binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:3697960 |
IMP: Inferred from Mutant Phenotype |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:3521520 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:5306302 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:5306310 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:5306555 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:3521520 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:5306302 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:5306310 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:5306555 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0006417 |
regulation of translation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006950 |
response to stress |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007265 |
Ras protein signal transduction |
MGI:MGI:3697960 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0007265 |
Ras protein signal transduction |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0016301 |
kinase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0418 |
F |
From MGI |
||
| GO:0016310 |
phosphorylation |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0418 |
P |
From MGI |
||
| GO:0016740 |
transferase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0808 |
F |
From MGI |
||
| GO:0016772 |
transferase activity, transferring phosphorus-containing groups |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0032007 |
negative regulation of TOR signaling cascade |
MGI:MGI:5306547 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0046777 |
protein autophosphorylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0051019 |
mitogen-activated protein kinase binding |
MGI:MGI:5306302 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0051019 |
mitogen-activated protein kinase binding |
MGI:MGI:5306310 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0090400 |
stress-induced premature senescence |
MGI:MGI:3697960 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0090400 |
stress-induced premature senescence |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Sun P et al. (2007) PRAK is essential for ras-induced senescence and tumor suppression. Cell 128: 295-308 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Schumacher S et al. (2004) Scaffolding by ERK3 regulates MK5 in development. EMBO J 23: 4770-9 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Kant S et al. (2006) Characterization of the atypical MAPK ERK4 and its activation of the MAPK-activated protein kinase MK5. J Biol Chem 281: 35511-9 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Seternes OM et al. (2004) Activation of MK5/PRAK by the atypical MAP kinase ERK3 defines a novel signal transduction pathway. EMBO J 23: 4780-91 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Zheng M et al. (2011) Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1. Nat Cell Biol 13: 263-72 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Kostenko S et al. (2011) The diterpenoid alkaloid noroxoaconitine is a Mapkap kinase 5 (MK5/PRAK) inhibitor. Cell Mol Life Sci 68: 289-301 PubMed GONUTS page
