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MGI:Mapk8
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Mapk8 ( synonyms: c-Jun N-terminal kinase, JNK1, Prkm8 ) | |
| Protein Name(s) | mitogen-activated protein kinase 8, | |
| External Links | ||
| MGI | MGI:1346861 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000165 |
MAPK cascade |
MGI:MGI:2152096 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0000165 |
MAPK cascade |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0000166 |
nucleotide binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0547 |
F |
From MGI |
||
| GO:0001503 |
ossification |
MGI:MGI:3575204 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0004672 |
protein kinase activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0004674 |
protein serine/threonine kinase activity |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0004705 |
JUN kinase activity |
MGI:MGI:1855744 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004705 |
JUN kinase activity |
MGI:MGI:3573812 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004705 |
JUN kinase activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0004705 |
JUN kinase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0004707 |
MAP kinase activity |
MGI:MGI:2152096 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0004707 |
MAP kinase activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:1352260 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:1890011 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:2182167 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:5009191 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005524 |
ATP binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0067 |
F |
From MGI |
||
| GO:0005524 |
ATP binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
InterPro:IPR008351 |
F |
From MGI |
||
| GO:0005634 |
nucleus |
MGI:MGI:3044255 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:3574697 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:3044255 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005739 |
mitochondrion |
MGI:MGI:3774218 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005739 |
mitochondrion |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005829 |
cytosol |
MGI:MGI:3774218 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006468 |
protein phosphorylation |
MGI:MGI:3575843 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006954 |
inflammatory response |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006970 |
response to osmotic stress |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007165 |
signal transduction |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007254 |
JNK cascade |
MGI:MGI:1855744 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007254 |
JNK cascade |
MGI:MGI:3799599 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007254 |
JNK cascade |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007258 |
JUN phosphorylation |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007258 |
JUN phosphorylation |
MGI:MGI:3032484 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2384141 |
P |
From MGI |
||
| GO:0007258 |
JUN phosphorylation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0009408 |
response to heat |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0009411 |
response to UV |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0010628 |
positive regulation of gene expression |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0016301 |
kinase activity |
MGI:MGI:2664443 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0016301 |
kinase activity |
MGI:MGI:3574697 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0016301 |
kinase activity |
MGI:MGI:3575843 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0016310 |
phosphorylation |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0418 |
P |
From MGI |
||
| GO:0016740 |
transferase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0808 |
F |
From MGI |
||
| GO:0016772 |
transferase activity, transferring phosphorus-containing groups |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0018105 |
peptidyl-serine phosphorylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0018107 |
peptidyl-threonine phosphorylation |
MGI:MGI:3032484 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2384141 |
P |
From MGI |
||
| GO:0018107 |
peptidyl-threonine phosphorylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030335 |
positive regulation of cell migration |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0031063 |
regulation of histone deacetylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0031116 |
positive regulation of microtubule polymerization |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0031175 |
neuron projection development |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0031558 |
induction of apoptosis in response to chemical stimulus |
MGI:MGI:3619752 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1346862 |
P |
From MGI |
||
| GO:0031982 |
vesicle |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0032091 |
negative regulation of protein binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0032839 |
dendrite cytoplasm |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0032880 |
regulation of protein localization |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0033267 |
axon part |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0035033 |
histone deacetylase regulator activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0042542 |
response to hydrogen peroxide |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042826 |
histone deacetylase binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0043066 |
negative regulation of apoptotic process |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043066 |
negative regulation of apoptotic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043204 |
perikaryon |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0045740 |
positive regulation of DNA replication |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0046686 |
response to cadmium ion |
MGI:MGI:3619752 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1346862 |
P |
From MGI |
||
| GO:0048263 |
determination of dorsal identity |
MGI:MGI:3799599 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0090045 |
positive regulation of deacetylase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:2000017 |
positive regulation of determination of dorsal identity |
MGI:MGI:3797993 |
IDA: Inferred from Direct Assay |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Yamashita M et al. (2005) Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation. Cell 121: 101-13 PubMed GONUTS page
- ↑ 2.0 2.1 Dong C et al. (2000) JNK is required for effector T-cell function but not for T-cell activation. Nature 405: 91-4 PubMed GONUTS page
- ↑ Luo W et al. (2005) Axin contains three separable domains that confer intramolecular, homodimeric, and heterodimeric interactions involved in distinct functions. J Biol Chem 280: 5054-60 PubMed GONUTS page
- ↑ Kelkar N et al. (2000) Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3. Mol Cell Biol 20: 1030-43 PubMed GONUTS page
- ↑ Ito M et al. (1999) JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway. Mol Cell Biol 19: 7539-48 PubMed GONUTS page
- ↑ Whitmarsh AJ et al. (2001) Requirement of the JIP1 scaffold protein for stress-induced JNK activation. Genes Dev 15: 2421-32 PubMed GONUTS page
- ↑ Wang T et al. (2001) Glutathione S-transferase P1-1 (GSTP1-1) inhibits c-Jun N-terminal kinase (JNK1) signaling through interaction with the C terminus. J Biol Chem 276: 20999-1003 PubMed GONUTS page
- ↑ 8.0 8.1 Robert K et al. (2004) The neuronal SAPK/JNK pathway is altered in a murine model of hyperhomocysteinemia. J Neurochem 89: 33-43 PubMed GONUTS page
- ↑ 9.0 9.1 Lee AF et al. (2004) Evidence that DeltaNp73 promotes neuronal survival by p53-dependent and p53-independent mechanisms. J Neurosci 24: 9174-84 PubMed GONUTS page
- ↑ 10.0 10.1 Baines CP et al. (2002) Mitochondrial PKCepsilon and MAPK form signaling modules in the murine heart: enhanced mitochondrial PKCepsilon-MAPK interactions and differential MAPK activation in PKCepsilon-induced cardioprotection. Circ Res 90: 390-7 PubMed GONUTS page
- ↑ 11.0 11.1 Kelkar N et al. (2005) Role of the JIP4 scaffold protein in the regulation of mitogen-activated protein kinase signaling pathways. Mol Cell Biol 25: 2733-43 PubMed GONUTS page
- ↑ 12.0 12.1 Rui Y et al. (2007) A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida. Dev Cell 13: 268-82 PubMed GONUTS page
- ↑ 13.0 13.1 Yu C et al. (2004) JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD. Mol Cell 13: 329-40 PubMed GONUTS page
- ↑ Holgado-Madruga M & Wong AJ (2003) Gab1 is an integrator of cell death versus cell survival signals in oxidative stress. Mol Cell Biol 23: 4471-84 PubMed GONUTS page
- ↑ 15.0 15.1 Papadakis ES et al. (2006) The regulation of Bax by c-Jun N-terminal protein kinase (JNK) is a prerequisite to the mitochondrial-induced apoptotic pathway. FEBS Lett 580: 1320-6 PubMed GONUTS page
- ↑ Lu Z et al. (2008) Protein encoded by the Axin(Fu) allele effectively down-regulates Wnt signaling but exerts a dominant negative effect on c-Jun N-terminal kinase signaling. J Biol Chem 283: 13132-9 PubMed GONUTS page
