Ambox notice.png

GONUTS is under stress! The website is currently experiencing long-wait times and frequent time-outs due to the record number of students, groups, and annotations related to CACAO this semester. We are currently working on increasing performance -- please accept our apologies for the technical difficulties.

You can help reduce stress on the server by:

  1. not reloading pages frequently - this just adds
  2. opening links in new windows (so you can read the old page)

MGI:Mapk1

From GONUTS
Jump to: navigation, search

Contents

Species (Taxon ID) Mus musculus (house mouse) (taxon:10090)
Gene Name(s) Mapk1 ( synonyms: Erk2, MAPK2, p42mapk, Prkm1 )
Protein Name(s) mitogen-activated protein kinase 1,
External Links
MGI MGI:1346858

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000165

MAPK cascade

MGI:MGI:1095647
PMID:9254656[1]

IDA: Inferred from Direct Assay

P

From MGI

GO:0000165

MAPK cascade

MGI:MGI:2176412
PMID:11841548[2]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0000165

MAPK cascade

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P63086

P

From MGI

GO:0000165

MAPK cascade

MGI:MGI:5004778
PMID:18084034[3]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0000165

MAPK cascade

MGI:MGI:79455
PMID:8626447[4]

IDA: Inferred from Direct Assay

P

From MGI

GO:0000165

MAPK cascade

MGI:MGI:82729
PMID:9064344[5]

IDA: Inferred from Direct Assay

P

From MGI

GO:0000166

nucleotide binding

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0547

F

From MGI

GO:0000189

MAPK import into nucleus

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P63086

P

From MGI

GO:0001784

phosphotyrosine binding

MGI:MGI:2680875
PMID:14636584[6]

IMP: Inferred from Mutant Phenotype

F

From MGI

GO:0004672

protein kinase activity

MGI:MGI:3032469
PMID:14744933[7]

IDA: Inferred from Direct Assay

F

From MGI

GO:0004672

protein kinase activity

MGI:MGI:3801245
PMID:18378670[8]

IDA: Inferred from Direct Assay

F

From MGI

GO:0004674

protein serine/threonine kinase activity

MGI:MGI:2154458

ISO: Inferred from Sequence Orthology

UniProtKB:P63086

F

From MGI

GO:0004674

protein serine/threonine kinase activity

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P28482

F

From MGI

GO:0004707

MAP kinase activity

MGI:MGI:1095647
PMID:9254656[1]

IDA: Inferred from Direct Assay

F

From MGI

GO:0004707

MAP kinase activity

MGI:MGI:2176412
PMID:11841548[2]

IMP: Inferred from Mutant Phenotype

F

From MGI

GO:0004707

MAP kinase activity

MGI:MGI:2387280
PMID:12223545[9]

IDA: Inferred from Direct Assay

F

From MGI

GO:0004707

MAP kinase activity

MGI:MGI:3054501
PMID:15314156[10]

IDA: Inferred from Direct Assay

F

From MGI

GO:0004707

MAP kinase activity

MGI:MGI:3579196
PMID:15896720[11]

IDA: Inferred from Direct Assay

F

From MGI

GO:0004707

MAP kinase activity

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P63086

F

From MGI

GO:0004707

MAP kinase activity

MGI:MGI:5004778
PMID:18084034[3]

IDA: Inferred from Direct Assay

F

From MGI

GO:0004707

MAP kinase activity

MGI:MGI:5004778
PMID:18084034[3]

IMP: Inferred from Mutant Phenotype

F

From MGI

GO:0004707

MAP kinase activity

MGI:MGI:79455
PMID:8626447[4]

IDA: Inferred from Direct Assay

F

From MGI

GO:0004707

MAP kinase activity

MGI:MGI:82729
PMID:9064344[5]

IDA: Inferred from Direct Assay

F

From MGI

GO:0005515

protein binding

MGI:MGI:3688344
PMID:15102471[12]

IPI: Inferred from Physical Interaction

UniProtKB:Q03172
UniProtKB:Q8CDB0
UniProtKB:Q8R332-1
UniProtKB:Q9Z2B9

F

From MGI

GO:0005515

protein binding

MGI:MGI:3773764
PMID:18045539[13]

IPI: Inferred from Physical Interaction

UniProtKB:P49841

F

From MGI

GO:0005515

protein binding

MGI:MGI:4359331
PMID:19455133[14]

IPI: Inferred from Physical Interaction

UniProtKB:Q62108

F

From MGI

GO:0005524

ATP binding

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P63086

F

From MGI

GO:0005625

soluble fraction

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P63086

C

From MGI

GO:0005626

insoluble fraction

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P63086

C

From MGI

GO:0005634

nucleus

MGI:MGI:2158593
PMID:11726647[15]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005634

nucleus

MGI:MGI:2669567
PMID:12925581[16]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005634

nucleus

MGI:MGI:3607037
PMID:16251435[17]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005634

nucleus

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P63086

C

From MGI

GO:0005634

nucleus

MGI:MGI:5306570
PMID:19565474[18]

TAS: Traceable Author Statement

C

From MGI

GO:0005654

nucleoplasm

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P63086

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:2158593
PMID:11726647[15]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:2387280
PMID:12223545[9]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:2669567
PMID:12925581[16]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005739

mitochondrion

MGI:MGI:3774218
PMID:11884367[19]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005739

mitochondrion

MGI:MGI:5306570
PMID:19565474[18]

TAS: Traceable Author Statement

C

From MGI

GO:0005769

early endosome

MGI:MGI:5306570
PMID:19565474[18]

TAS: Traceable Author Statement

C

From MGI

GO:0005770

late endosome

MGI:MGI:5306570
PMID:19565474[18]

TAS: Traceable Author Statement

C

From MGI

GO:0005794

Golgi apparatus

MGI:MGI:5306570
PMID:19565474[18]

TAS: Traceable Author Statement

C

From MGI

GO:0005829

cytosol

MGI:MGI:1201213
PMID:9447983[20]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005829

cytosol

MGI:MGI:3774218
PMID:11884367[19]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005829

cytosol

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P63086

C

From MGI

GO:0005829

cytosol

MGI:MGI:5306570
PMID:19565474[18]

TAS: Traceable Author Statement

C

From MGI

GO:0005856

cytoskeleton

MGI:MGI:5306570
PMID:19565474[18]

TAS: Traceable Author Statement

C

From MGI

GO:0005901

caveola

MGI:MGI:5306570
PMID:19565474[18]

TAS: Traceable Author Statement

C

From MGI

GO:0005925

focal adhesion

MGI:MGI:5306570
PMID:19565474[18]

TAS: Traceable Author Statement

C

From MGI

GO:0006351

transcription, DNA-dependent

MGI:MGI:3793922
PMID:7889942[21]

NAS: Non-traceable Author Statement

P

From MGI

GO:0006468

protein phosphorylation

MGI:MGI:2176412
PMID:11841548[2]

IDA: Inferred from Direct Assay

P

From MGI

GO:0006468

protein phosphorylation

MGI:MGI:3032469
PMID:14744933[7]

IDA: Inferred from Direct Assay

P

From MGI

GO:0006468

protein phosphorylation

MGI:MGI:3510481
PMID:15284227[22]

IDA: Inferred from Direct Assay

P

From MGI

GO:0006468

protein phosphorylation

MGI:MGI:3579196
PMID:15896720[11]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0006468

protein phosphorylation

MGI:MGI:3801245
PMID:18378670[8]

IDA: Inferred from Direct Assay

P

From MGI

GO:0006468

protein phosphorylation

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P63086

P

From MGI

GO:0006915

apoptotic process

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0053

P

From MGI

GO:0006974

response to DNA damage stimulus

MGI:MGI:3057054
PMID:15383658[23]

IDA: Inferred from Direct Assay

P

From MGI

GO:0007049

cell cycle

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0131

P

From MGI

GO:0007165

signal transduction

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P63086

P

From MGI

GO:0008134

transcription factor binding

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P63086

F

From MGI

GO:0008353

RNA polymerase II carboxy-terminal domain kinase activity

MGI:MGI:4411983
PMID:12721286[24]

IDA: Inferred from Direct Assay

F

From MGI

GO:0009636

response to toxin

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P63086

P

From MGI

GO:0009887

organ morphogenesis

MGI:MGI:2152296
PMID:11684667[25]

IDA: Inferred from Direct Assay

P

From MGI

GO:0010800

positive regulation of peptidyl-threonine phosphorylation

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P28482

P

From MGI

GO:0016301

kinase activity

MGI:MGI:2664443
PMID:12808090[26]

IDA: Inferred from Direct Assay

F

From MGI

GO:0016301

kinase activity

MGI:MGI:3510481
PMID:15284227[22]

IDA: Inferred from Direct Assay

F

From MGI

GO:0016310

phosphorylation

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0418

P

From MGI

GO:0016740

transferase activity

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0808

F

From MGI

GO:0016772

transferase activity, transferring phosphorus-containing groups

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR011009

F

From MGI

GO:0018105

peptidyl-serine phosphorylation

MGI:MGI:2154458

ISO: Inferred from Sequence Orthology

UniProtKB:P63086

P

From MGI

GO:0018105

peptidyl-serine phosphorylation

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P28482

P

From MGI

GO:0018105

peptidyl-serine phosphorylation

MGI:MGI:5004778
PMID:18084034[3]

IDA: Inferred from Direct Assay

P

From MGI

GO:0018105

peptidyl-serine phosphorylation

MGI:MGI:5004778
PMID:18084034[3]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0019233

sensory perception of pain

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P63086

P

From MGI

GO:0019858

cytosine metabolic process

MGI:MGI:3510481
PMID:15284227[22]

IDA: Inferred from Direct Assay

P

From MGI

GO:0019902

phosphatase binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P28482

F

From MGI

GO:0031143

pseudopodium

MGI:MGI:2673740
PMID:12821670[27]

IDA: Inferred from Direct Assay

C

From MGI

GO:0031435

mitogen-activated protein kinase kinase kinase binding

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P63086

F

From MGI

GO:0031663

lipopolysaccharide-mediated signaling pathway

MGI:MGI:2670551
PMID:12872135[28]

IDA: Inferred from Direct Assay

P

From MGI

GO:0032496

response to lipopolysaccharide

MGI:MGI:2670551
PMID:12872135[28]

IDA: Inferred from Direct Assay

P

From MGI

GO:0032839

dendrite cytoplasm

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P63086

C

From MGI

GO:0032872

regulation of stress-activated MAPK cascade

MGI:MGI:5306570
PMID:19565474[18]

TAS: Traceable Author Statement

P

From MGI

GO:0033267

axon part

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P63086

C

From MGI

GO:0033598

mammary gland epithelial cell proliferation

MGI:MGI:3835718
PMID:18604197[29]

IDA: Inferred from Direct Assay

P

From MGI

GO:0035556

intracellular signal transduction

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P63086

P

From MGI

GO:0042221

response to chemical stimulus

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P63086

P

From MGI

GO:0043204

perikaryon

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P63086

C

From MGI

GO:0043234

protein complex

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P63086

C

From MGI

GO:0043330

response to exogenous dsRNA

MGI:MGI:2670551
PMID:12872135[28]

IDA: Inferred from Direct Assay

P

From MGI

GO:0043627

response to estrogen stimulus

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P63086

P

From MGI

GO:0045596

negative regulation of cell differentiation

MGI:MGI:3037515
PMID:14970190[30]

IGI: Inferred from Genetic Interaction

MGI:MGI:96382

P

From MGI

GO:0045727

positive regulation of translation

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P63086

P

From MGI

GO:0050852

T cell receptor signaling pathway

MGI:MGI:82729
PMID:9064344[5]

IDA: Inferred from Direct Assay

P

From MGI

GO:0050853

B cell receptor signaling pathway

MGI:MGI:1095647
PMID:9254656[1]

IDA: Inferred from Direct Assay

P

From MGI

GO:0051090

regulation of sequence-specific DNA binding transcription factor activity

MGI:MGI:3793922
PMID:7889942[21]

NAS: Non-traceable Author Statement

P

From MGI

GO:0051493

regulation of cytoskeleton organization

MGI:MGI:5306570
PMID:19565474[18]

TAS: Traceable Author Statement

P

From MGI

GO:0060716

labyrinthine layer blood vessel development

MGI:MGI:3041910
PMID:14622137[31]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3055889

P

From MGI

GO:0070371

ERK1 and ERK2 cascade

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P28482

P

From MGI

GO:0072584

caveolin-mediated endocytosis

MGI:MGI:5306570
PMID:19565474[18]

TAS: Traceable Author Statement

P

From MGI

GO:0090170

regulation of Golgi inheritance

MGI:MGI:5306570
PMID:19565474[18]

TAS: Traceable Author Statement

P

From MGI

GO:2000641

regulation of early endosome to late endosome transport

MGI:MGI:5306570
PMID:19565474[18]

TAS: Traceable Author Statement

P

From MGI


edit table

Notes

References

See Help:References for how to manage references in GONUTS.
  1. ↑ 1.0 1.1 1.2 Pani G et al. (1997) The motheaten mutation rescues B cell signaling and development in CD45-deficient mice. J Exp Med 186: 581-8 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 Baxter RM & Brissette JL (2002) Role of the nude gene in epithelial terminal differentiation. J Invest Dermatol 118: 303-9 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 3.4 Lee SH et al. (2008) ERK is a novel regulatory kinase for poly(A) polymerase. Nucleic Acids Res 36: 803-13 PubMed GONUTS page
  4. ↑ 4.0 4.1 Richards JD et al. (1996) Reconstitution of B cell antigen receptor-induced signaling events in a nonlymphoid cell line by expressing the Syk protein-tyrosine kinase. J Biol Chem 271: 6458-66 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 Pani G et al. (1996) Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphatase. J Exp Med 184: 839-52 PubMed GONUTS page
  6. ↑ Ishibe S et al. (2003) Phosphorylation-dependent paxillin-ERK association mediates hepatocyte growth factor-stimulated epithelial morphogenesis. Mol Cell 12: 1275-85 PubMed GONUTS page
  7. ↑ 7.0 7.1 Fan M et al. (2004) Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK. Genes Dev 18: 278-89 PubMed GONUTS page
  8. ↑ 8.0 8.1 Soond SM et al. (2008) ERK and the F-box protein betaTRCP target STAT1 for degradation. J Biol Chem 283: 16077-83 PubMed GONUTS page
  9. ↑ 9.0 9.1 Noshita N et al. (2002) Copper/zinc superoxide dismutase attenuates neuronal cell death by preventing extracellular signal-regulated kinase activation after transient focal cerebral ischemia in mice. J Neurosci 22: 7923-30 PubMed GONUTS page
  10. ↑ Higuchi T et al. (2004) MUC20 suppresses the hepatocyte growth factor-induced Grb2-Ras pathway by binding to a multifunctional docking site of met. Mol Cell Biol 24: 7456-68 PubMed GONUTS page
  11. ↑ 11.0 11.1 Kim MY et al. (2005) Presenilin acts as a positive regulator of basal level activity of ERK through the Raf-MEK1 signaling pathway. Biochem Biophys Res Commun 332: 609-13 PubMed GONUTS page
  12. ↑ Papin J & Subramaniam S (2004) Bioinformatics and cellular signaling. Curr Opin Biotechnol 15: 78-81 PubMed GONUTS page
  13. ↑ Fuentealba LC et al. (2007) Integrating patterning signals: Wnt/GSK3 regulates the duration of the BMP/Smad1 signal. Cell 131: 980-93 PubMed GONUTS page
  14. ↑ Fernández E et al. (2009) Targeted tandem affinity purification of PSD-95 recovers core postsynaptic complexes and schizophrenia susceptibility proteins. Mol Syst Biol 5: 269 PubMed GONUTS page
  15. ↑ 15.0 15.1 Stanciu M & DeFranco DB (2002) Prolonged nuclear retention of activated extracellular signal-regulated protein kinase promotes cell death generated by oxidative toxicity or proteasome inhibition in a neuronal cell line. J Biol Chem 277: 4010-7 PubMed GONUTS page
  16. ↑ 16.0 16.1 Corson LB et al. (2003) Spatial and temporal patterns of ERK signaling during mouse embryogenesis. Development 130: 4527-37 PubMed GONUTS page
  17. ↑ Moosmang S et al. (2005) Role of hippocampal Cav1.2 Ca2+ channels in NMDA receptor-independent synaptic plasticity and spatial memory. J Neurosci 25: 9883-92 PubMed GONUTS page
  18. ↑ 18.00 18.01 18.02 18.03 18.04 18.05 18.06 18.07 18.08 18.09 18.10 18.11 18.12 18.13 Yao Z & Seger R (2009) The ERK signaling cascade--views from different subcellular compartments. Biofactors 35: 407-16 PubMed GONUTS page
  19. ↑ 19.0 19.1 Baines CP et al. (2002) Mitochondrial PKCepsilon and MAPK form signaling modules in the murine heart: enhanced mitochondrial PKCepsilon-MAPK interactions and differential MAPK activation in PKCepsilon-induced cardioprotection. Circ Res 90: 390-7 PubMed GONUTS page
  20. ↑ Ribon V et al. (1998) A novel, multifuntional c-Cbl binding protein in insulin receptor signaling in 3T3-L1 adipocytes. Mol Cell Biol 18: 872-9 PubMed GONUTS page
  21. ↑ 21.0 21.1 Gille H et al. (1995) ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation. EMBO J 14: 951-62 PubMed GONUTS page
  22. ↑ 22.0 22.1 22.2 Castelli M et al. (2004) MAP kinase phosphatase 3 (MKP3) interacts with and is phosphorylated by protein kinase CK2alpha. J Biol Chem 279: 44731-9 PubMed GONUTS page
  23. ↑ You H et al. (2004) p53-dependent inhibition of FKHRL1 in response to DNA damage through protein kinase SGK1. Proc Natl Acad Sci U S A 101: 14057-62 PubMed GONUTS page
  24. ↑ Yeo M et al. (2003) A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5. J Biol Chem 278: 26078-85 PubMed GONUTS page
  25. ↑ Fisher CE et al. (2001) Erk MAP kinase regulates branching morphogenesis in the developing mouse kidney. Development 128: 4329-38 PubMed GONUTS page
  26. ↑ Holgado-Madruga M & Wong AJ (2003) Gab1 is an integrator of cell death versus cell survival signals in oxidative stress. Mol Cell Biol 23: 4471-84 PubMed GONUTS page
  27. ↑ Ge L et al. (2003) A beta-arrestin-dependent scaffold is associated with prolonged MAPK activation in pseudopodia during protease-activated receptor-2-induced chemotaxis. J Biol Chem 278: 34418-26 PubMed GONUTS page
  28. ↑ 28.0 28.1 28.2 Hoebe K et al. (2003) Identification of Lps2 as a key transducer of MyD88-independent TIR signalling. Nature 424: 743-8 PubMed GONUTS page
  29. ↑ Nojima H et al. (2008) IQGAP3 regulates cell proliferation through the Ras/ERK signalling cascade. Nat Cell Biol 10: 971-8 PubMed GONUTS page
  30. ↑ Dacquin R et al. (2004) Amylin inhibits bone resorption while the calcitonin receptor controls bone formation in vivo. J Cell Biol 164: 509-14 PubMed GONUTS page
  31. ↑ Hatano N et al. (2003) Essential role for ERK2 mitogen-activated protein kinase in placental development. Genes Cells 8: 847-56 PubMed GONUTS page
Retrieved from "http://gowiki.tamu.edu/wiki/index.php/MGI:Mapk1"
Personal tools
Namespaces
Variants
Actions
Navigation
Cacao
Journal Clubs
page contributors
Toolbox