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MGI:Map3k1
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Map3k1 ( synonyms: Mekk, MEKK1 ) | |
| Protein Name(s) | mitogen-activated protein kinase kinase kinase 1, | |
| External Links | ||
| MGI | MGI:1346872 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000165 |
MAPK cascade |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0000166 |
nucleotide binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0547 |
F |
From MGI |
||
| GO:0000186 |
activation of MAPKK activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0000209 |
protein polyubiquitination |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0004672 |
protein kinase activity |
MGI:MGI:3040582 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0004706 |
JUN kinase kinase kinase activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0004710 |
MAPK/ERK kinase kinase activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0004842 |
ubiquitin-protein ligase activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:2675925 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3799599 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005524 |
ATP binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0067 |
F |
From MGI |
||
| GO:0005622 |
intracellular |
MGI:MGI:3032484 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005624 |
membrane fraction |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006468 |
protein phosphorylation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006468 |
protein phosphorylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006970 |
response to osmotic stress |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007179 |
transforming growth factor beta receptor signaling pathway |
MGI:MGI:2674169 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2676654 |
P |
From MGI |
||
| GO:0007254 |
JNK cascade |
MGI:MGI:3032484 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007256 |
activation of JNKK activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007257 |
activation of JUN kinase activity |
MGI:MGI:3032484 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0008432 |
JUN kinase binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0008545 |
JUN kinase kinase activity |
MGI:MGI:3032484 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0008637 |
apoptotic mitochondrial changes |
MGI:MGI:3577836 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0018105 |
peptidyl-serine phosphorylation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0019901 |
protein kinase binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0030334 |
regulation of cell migration |
MGI:MGI:2674169 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2676654 |
P |
From MGI |
||
| GO:0030838 |
positive regulation of actin filament polymerization |
MGI:MGI:2674169 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2676654 |
P |
From MGI |
||
| GO:0031434 |
mitogen-activated protein kinase kinase binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0032232 |
negative regulation of actin filament bundle assembly |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042060 |
wound healing |
MGI:MGI:2674169 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2676654 |
P |
From MGI |
||
| GO:0042787 |
protein ubiquitination involved in ubiquitin-dependent protein catabolic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043010 |
camera-type eye development |
MGI:MGI:2674169 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2676654 |
P |
From MGI |
||
| GO:0043065 |
positive regulation of apoptotic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043406 |
positive regulation of MAP kinase activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043507 |
positive regulation of JUN kinase activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0046625 |
sphingolipid binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0046777 |
protein autophosphorylation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0046872 |
metal ion binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0479 |
F |
From MGI |
||
| GO:0050434 |
positive regulation of viral transcription |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0051019 |
mitogen-activated protein kinase binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0051259 |
protein oligomerization |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
|
colocalizes_with |
GO:0005856 |
cytoskeleton |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Xu LG et al. (2004) TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces apoptosis. J Biol Chem 279: 17278-82 PubMed GONUTS page
- ↑ Wang WL et al. (2003) PICK1, an anchoring protein that specifically targets protein kinase Calpha to mitochondria selectively upon serum stimulation in NIH 3T3 cells. J Biol Chem 278: 37705-12 PubMed GONUTS page
- ↑ Rui Y et al. (2007) A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida. Dev Cell 13: 268-82 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Yu C et al. (2004) JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD. Mol Cell 13: 329-40 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 Zhang L et al. (2003) A role for MEK kinase 1 in TGF-beta/activin-induced epithelium movement and embryonic eyelid closure. EMBO J 22: 4443-54 PubMed GONUTS page
- ↑ Mendoza FJ et al. (2005) MEKK1-induced apoptosis is mediated by Smac/Diablo release from the mitochondria. Biochem Biophys Res Commun 331: 1089-98 PubMed GONUTS page
