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MGI:Malt1
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Malt1 ( synonyms: paracaspase ) | |
| Protein Name(s) | mucosa associated lymphoid tissue lymphoma translocation gene 1, | |
| External Links | ||
| MGI | MGI:2445027 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001923 |
B-1 B cell differentiation |
MGI:MGI:3629264 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3639305 |
P |
From MGI |
||
| GO:0002020 |
protease binding |
MGI:MGI:4943389 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0002726 |
positive regulation of T cell cytokine production |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0004197 |
cysteine-type endopeptidase activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0004842 |
ubiquitin-protein ligase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0004871 |
signal transducer activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3656456 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:2665373 |
RCA: Inferred from Reviewed Computational Analysis |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005829 |
cytosol |
MGI:MGI:3694380 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0006508 |
proteolysis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006915 |
apoptotic process |
MGI:MGI:2665373 |
RCA: Inferred from Reviewed Computational Analysis |
P |
From MGI |
|||
| GO:0007249 |
I-kappaB kinase/NF-kappaB cascade |
MGI:MGI:2665373 |
RCA: Inferred from Reviewed Computational Analysis |
P |
From MGI |
|||
| GO:0007250 |
activation of NF-kappaB-inducing kinase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0008152 |
metabolic process |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0378 |
P |
From MGI |
||
| GO:0008152 |
metabolic process |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0008233 |
peptidase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0009620 |
response to fungus |
MGI:MGI:3654747 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3639305 |
P |
From MGI |
||
| GO:0016567 |
protein ubiquitination |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0016787 |
hydrolase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0378 |
F |
From MGI |
||
| GO:0032743 |
positive regulation of interleukin-2 production |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042098 |
T cell proliferation |
MGI:MGI:2682077 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2684761 |
P |
From MGI |
||
| GO:0042113 |
B cell activation |
MGI:MGI:2682077 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2684761 |
P |
From MGI |
||
| GO:0042327 |
positive regulation of phosphorylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042981 |
regulation of apoptotic process |
MGI:MGI:2665373 |
ISA: Inferred from Sequence Alignment |
P |
From MGI |
|||
| GO:0043123 |
positive regulation of I-kappaB kinase/NF-kappaB cascade |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043234 |
protein complex |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0043621 |
protein self-association |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0050852 |
T cell receptor signaling pathway |
MGI:MGI:3694380 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0050852 |
T cell receptor signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0050856 |
regulation of T cell receptor signaling pathway |
MGI:MGI:3629264 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3639305 |
P |
From MGI |
||
| GO:0050870 |
positive regulation of T cell activation |
MGI:MGI:3629264 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3639305 |
P |
From MGI |
||
| GO:0051092 |
positive regulation of NF-kappaB transcription factor activity |
MGI:MGI:3629264 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3639305 |
P |
From MGI |
||
| GO:0051092 |
positive regulation of NF-kappaB transcription factor activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0051168 |
nuclear export |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0051259 |
protein oligomerization |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Ruland J et al. (2003) Differential requirement for Malt1 in T and B cell antigen receptor signaling. Immunity 19: 749-58 PubMed GONUTS page
- ↑ Coornaert B et al. (2008) T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20. Nat Immunol 9: 263-71 PubMed GONUTS page
- ↑ Rossman JS et al. (2006) POLKADOTS are foci of functional interactions in T-Cell receptor-mediated signaling to NF-kappaB. Mol Biol Cell 17: 2166-76 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Reed JC et al. (2003) Comparative analysis of apoptosis and inflammation genes of mice and humans. Genome Res 13: 1376-88 PubMed GONUTS page
- ↑ 5.0 5.1 Dong W et al. (2006) The IRAK-1-BCL10-MALT1-TRAF6-TAK1 cascade mediates signaling to NF-kappaB from Toll-like receptor 4. J Biol Chem 281: 26029-40 PubMed GONUTS page
- ↑ Gross O et al. (2006) Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity. Nature 442: 651-6 PubMed GONUTS page
- ↑ 7.0 7.1 Ruefli-Brasse AA et al. (2003) Regulation of NF-kappaB-dependent lymphocyte activation and development by paracaspase. Science 302: 1581-4 PubMed GONUTS page
