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MGI:Macf1
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Macf1 ( synonyms: Acf7, Aclp7, trabeculin alpha ) | |
| Protein Name(s) | microtubule-actin crosslinking factor 1, | |
| External Links | ||
| MGI | MGI:108559 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001707 |
mesoderm formation |
MGI:MGI:3640889 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3652899 |
P |
From MGI |
||
| GO:0003779 |
actin binding |
MGI:MGI:2679921 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003779 |
actin binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005509 |
calcium ion binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3640889 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3828223 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:3640889 |
IMP: Inferred from Mutant Phenotype |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4947903 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005794 |
Golgi apparatus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005856 |
cytoskeleton |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0206 |
C |
From MGI |
||
| GO:0005856 |
cytoskeleton |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0005874 |
microtubule |
MGI:MGI:3828223 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005874 |
microtubule |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005874 |
microtubule |
MGI:MGI:4947903 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005938 |
cell cortex |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006620 |
posttranslational protein targeting to membrane |
MGI:MGI:3640889 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0006928 |
cellular component movement |
MGI:MGI:2679921 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0007050 |
cell cycle arrest |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0007163 |
establishment or maintenance of cell polarity |
MGI:MGI:2679921 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0008017 |
microtubule binding |
MGI:MGI:2679921 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0008104 |
protein localization |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0010632 |
regulation of epithelial cell migration |
MGI:MGI:3828223 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0010632 |
regulation of epithelial cell migration |
MGI:MGI:4947903 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0015629 |
actin cytoskeleton |
MGI:MGI:2679921 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0015630 |
microtubule cytoskeleton |
MGI:MGI:2679921 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016020 |
membrane |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001129230 |
C |
From MGI |
||
| GO:0016055 |
Wnt receptor signaling pathway |
MGI:MGI:3640889 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1861437 |
P |
From MGI |
||
| GO:0016055 |
Wnt receptor signaling pathway |
MGI:MGI:3640889 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0016887 |
ATPase activity |
MGI:MGI:3828223 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0030177 |
positive regulation of Wnt receptor signaling pathway |
MGI:MGI:3640889 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0030177 |
positive regulation of Wnt receptor signaling pathway |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001129230 |
P |
From MGI |
||
| GO:0032587 |
ruffle membrane |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0032886 |
regulation of microtubule-based process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0032886 |
regulation of microtubule-based process |
MGI:MGI:4947903 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0042060 |
wound healing |
MGI:MGI:3828223 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0042060 |
wound healing |
MGI:MGI:4947903 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0042995 |
cell projection |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0966 |
C |
From MGI |
||
| GO:0043001 |
Golgi to plasma membrane protein transport |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0046872 |
metal ion binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0479 |
F |
From MGI |
||
| GO:0051893 |
regulation of focal adhesion assembly |
MGI:MGI:3828223 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Chen HJ et al. (2006) The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway. Genes Dev 20: 1933-45 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Kodama A et al. (2003) ACF7: an essential integrator of microtubule dynamics. Cell 115: 343-54 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 Wu X et al. (2008) ACF7 regulates cytoskeletal-focal adhesion dynamics and migration and has ATPase activity. Cell 135: 137-48 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 Wu X et al. (2011) Skin stem cells orchestrate directional migration by regulating microtubule-ACF7 connections through GSK3β. Cell 144: 341-52 PubMed GONUTS page
