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MGI:Lyst
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Lyst ( synonyms: D13Sfk13 ) | |
| Protein Name(s) | lysosomal trafficking regulator, | |
| External Links | ||
| MGI | MGI:107448 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0002446 |
neutrophil mediated immunity |
MGI:MGI:68578 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1855968 |
P |
From MGI |
||
| GO:0002456 |
T cell mediated immunity |
MGI:MGI:55165 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1855968 |
P |
From MGI |
||
| GO:0005623 |
cell |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1855968 |
C |
From MGI |
|||
| GO:0005623 |
cell |
MGI:MGI:55273 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1855968 |
C |
From MGI |
||
| GO:0005737 |
cytoplasm |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0963 |
C |
From MGI |
||
| GO:0005829 |
cytosol |
MGI:MGI:1099544 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0006644 |
phospholipid metabolic process |
MGI:MGI:54469 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1855968 |
P |
From MGI |
||
| GO:0006810 |
transport |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0813 |
P |
From MGI |
||
| GO:0007017 |
microtubule-based process |
MGI:MGI:54205 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1855968 |
P |
From MGI |
||
| GO:0007040 |
lysosome organization |
MGI:MGI:1099544 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1855968 |
P |
From MGI |
||
| GO:0007040 |
lysosome organization |
MGI:MGI:53816 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1855968 |
P |
From MGI |
||
| GO:0007040 |
lysosome organization |
MGI:MGI:53992 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1855968 |
P |
From MGI |
||
| GO:0007040 |
lysosome organization |
MGI:MGI:55104 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1855968 |
P |
From MGI |
||
| GO:0007040 |
lysosome organization |
MGI:MGI:56449 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1855968 |
P |
From MGI |
||
| GO:0007596 |
blood coagulation |
MGI:MGI:55798 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1855968 |
P |
From MGI |
||
| GO:0015031 |
protein transport |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0653 |
P |
From MGI |
||
| GO:0015630 |
microtubule cytoskeleton |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0030595 |
leukocyte chemotaxis |
MGI:MGI:53883 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1855968 |
P |
From MGI |
||
| GO:0032438 |
melanosome organization |
MGI:MGI:3618562 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3620573 |
P |
From MGI |
||
| GO:0032438 |
melanosome organization |
MGI:MGI:53824 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1855968 |
P |
From MGI |
||
| GO:0032510 |
endosome to lysosome transport via multivesicular body sorting pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0032816 |
positive regulation of natural killer cell activation |
MGI:MGI:55273 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1855968 |
P |
From MGI |
||
| GO:0033299 |
secretion of lysosomal enzymes |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1855968 |
P |
From MGI |
|||
| GO:0033299 |
secretion of lysosomal enzymes |
MGI:MGI:55273 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1855968 |
P |
From MGI |
||
| GO:0033364 |
mast cell secretory granule organization |
MGI:MGI:54412 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1855968 |
P |
From MGI |
||
| GO:0042267 |
natural killer cell mediated cytotoxicity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042493 |
response to drug |
MGI:MGI:77039 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1855968 |
P |
From MGI |
||
| GO:0042742 |
defense response to bacterium |
MGI:MGI:53883 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1855968 |
P |
From MGI |
||
| GO:0042742 |
defense response to bacterium |
MGI:MGI:53949 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1855968 |
P |
From MGI |
||
| GO:0042742 |
defense response to bacterium |
MGI:MGI:68578 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1855968 |
P |
From MGI |
||
| GO:0042832 |
defense response to protozoan |
MGI:MGI:55417 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1855968 |
P |
From MGI |
||
| GO:0043473 |
pigmentation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_445970 |
P |
From MGI |
||
| GO:0043473 |
pigmentation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043473 |
pigmentation |
MGI:MGI:55273 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1855968 |
P |
From MGI |
||
| GO:0043473 |
pigmentation |
MGI:MGI:56449 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1855968 |
P |
From MGI |
||
| GO:0043473 |
pigmentation |
MGI:MGI:73117 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2660913 |
P |
From MGI |
||
| GO:0043473 |
pigmentation |
MGI:MGI:77039 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1855968 |
P |
From MGI |
||
| GO:0048753 |
pigment granule organization |
MGI:MGI:54133 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1855968 |
P |
From MGI |
||
| GO:0051607 |
defense response to virus |
MGI:MGI:55120 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1855968 |
P |
From MGI |
||
| GO:0055091 |
phospholipid homeostasis |
MGI:MGI:54469 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1855968 |
P |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Tanaka E et al. (1994) Effects of the beige mutation on respiratory tract infection with Pseudomonas aeruginosa in mice. Exp Lung Res 20: 351-66 PubMed GONUTS page
- ↑ Saxena RK et al. (1982) Defective T-cell response in beige mutant mice. Nature 295: 240-1 PubMed GONUTS page
- ↑ 3.0 3.1 Brandt EJ et al. (1975) Defective lysosomal enzyme secretion in kidneys of Chediak-Higashi (beige) mice. J Cell Biol 67: 774-88 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Orn A et al. (1982) Pigment mutations in the mouse which also affect lysosomal functions lead to suppressed natural killer cell activity. Scand J Immunol 15: 305-10 PubMed GONUTS page
- ↑ 5.0 5.1 Perou CM et al. (1997) The Beige/Chediak-Higashi syndrome gene encodes a widely expressed cytosolic protein. J Biol Chem 272: 29790-4 PubMed GONUTS page
- ↑ 6.0 6.1 Prueitt JL et al. (1978) Pulmonary surface-active materials in the Chediak-Higashi syndrome. J Lipid Res 19: 410-5 PubMed GONUTS page
- ↑ Oliver JM (1976) Impaired microtubule function correctable by cyclic GMP and cholinergic agonists in the Chediak-Higashi syndrome. Am J Pathol 85: 395-418 PubMed GONUTS page
- ↑ Oliver C & Essner E (1973) Distribution of anomalous lysosomes in the beige mouse: a homologue of Chediak-Higashi syndrome. J Histochem Cytochem 21: 218-28 PubMed GONUTS page
- ↑ Oliver C & Essner E (1975) Formation of anomalous lysosomes in monocytes, neutrophils, and eosinophils from bone marrow of mice with Chédiak-Higashi syndrome. Lab Invest 32: 17-27 PubMed GONUTS page
- ↑ Willingham MC et al. (1981) The origin and fate of large dense bodies in beige mouse fibroblasts. Lysosomal fusion and exocytosis. Exp Cell Res 136: 157-68 PubMed GONUTS page
- ↑ 11.0 11.1 Ahmed F & Shire JG (1985) Lysosomal mutations inhibit lipofuscinosis of the spleen in C57BL mice. J Hered 76: 311-2 PubMed GONUTS page
- ↑ Novak EK et al. (1984) Platelet storage pool deficiency in mouse pigment mutations associated with seven distinct genetic loci. Blood 63: 536-44 PubMed GONUTS page
- ↑ 13.0 13.1 Gallin JI et al. (1974) Granulocyte function in the Chediak-Higashi syndrome of mice. Blood 43: 201-6 PubMed GONUTS page
- ↑ Runkel F et al. (2006) Grey, a novel mutation in the murine Lyst gene, causes the beige phenotype by skipping of exon 25. Mamm Genome 17: 203-10 PubMed GONUTS page
- ↑ Hearing VJ et al. (1973) The fine structure of melanogenesis in coat color mutants of the mouse. J Ultrastruct Res 43: 88-106 PubMed GONUTS page
- ↑ Chi EY et al. (1978) Mast cell granule formation in the beige mouse. J Histochem Cytochem 26: 131-7 PubMed GONUTS page
- ↑ 17.0 17.1 Ahmed F et al. (1989) Lysosomal mutations increase susceptibility to anaesthetics. Experientia 45: 1133-5 PubMed GONUTS page
- ↑ Elin RJ et al. (1974) Infection and immunoglobulin concentrations in Chediak-Higashi mice. Infect Immun 10: 88-91 PubMed GONUTS page
- ↑ Kirkpatrick CE & Farrell JP (1982) Leishmaniasis in beige mice. Infect Immun 38: 1208-16 PubMed GONUTS page
- ↑ PIERRO LJ & CHASE HB (1963) Slate--a new coat color mutant in the mouse. J Hered 54: 47-50 PubMed GONUTS page
- ↑ Robison WG Jr & Kuwabara T (1976) Light-induced alterations of retinal pigment epithelium in black, albino, and beige mice. Exp Eye Res 22: 549-57 PubMed GONUTS page
- ↑ Shellam GR et al. (1981) Increased susceptibility to cytomegalovirus infection in beige mutant mice. Proc Natl Acad Sci U S A 78: 5104-8 PubMed GONUTS page
