MGI:Lyn

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000166	nucleotide binding	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0547	F	From MGI
	GO:0001782	B cell homeostasis	MGI:MGI:894972 PMID:9252121^[1]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0001817	regulation of cytokine production	MGI:MGI:3703139 PMID:16272347^[2]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0001933	negative regulation of protein phosphorylation	MGI:MGI:2687173 PMID:14525964^[3]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0002431	Fc receptor mediated stimulatory signaling pathway	MGI:MGI:3703139 PMID:16272347^[2]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0002513	tolerance induction to self antigen	MGI:MGI:894972 PMID:9252121^[1]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0002553	histamine secretion by mast cell	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q07014	P	From MGI
	GO:0002576	platelet degranulation	MGI:MGI:5298337 PMID:20189992^[4]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0002762	negative regulation of myeloid leukocyte differentiation	MGI:MGI:2152233 PMID:11672542^[5]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0002768	immune response-regulating cell surface receptor signaling pathway	MGI:MGI:894972 PMID:9252121^[1]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0002774	Fc receptor mediated inhibitory signaling pathway	MGI:MGI:3703139 PMID:16272347^[2]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0002902	regulation of B cell apoptotic process	MGI:MGI:82730 PMID:9064343^[6]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0004672	protein kinase activity	MGI:MGI:85068 PMID:9000133^[7]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0004713	protein tyrosine kinase activity	MGI:MGI:1859033 PMID:10872802^[8]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0004713	protein tyrosine kinase activity	MGI:MGI:2152233 PMID:11672542^[5]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0004713	protein tyrosine kinase activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q07014	F	From MGI
	GO:0004713	protein tyrosine kinase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P07948	F	From MGI
	GO:0004713	protein tyrosine kinase activity	MGI:MGI:77358 PMID:7499277^[9]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0004715	non-membrane spanning protein tyrosine kinase activity	MGI:MGI:2152096	IEA: Inferred from Electronic Annotation	EC:2.7.10.2	F	From MGI
	GO:0004715	non-membrane spanning protein tyrosine kinase activity	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR020747	F	From MGI
	GO:0005102	receptor binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q07014	F	From MGI
	GO:0005128	erythropoietin receptor binding	MGI:MGI:3694161 PMID:10713104^[10]	TAS: Traceable Author Statement		F	From MGI
	GO:0005161	platelet-derived growth factor receptor binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q07014	F	From MGI
	GO:0005178	integrin binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q07014	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3694161 PMID:10713104^[10]	IPI: Inferred from Physical Interaction	UniProtKB:P49710	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3722965 PMID:17640867^[11]	IPI: Inferred from Physical Interaction	UniProtKB:Q99N69	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3769059 PMID:16249387^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q9EQR5	F	From MGI
	GO:0005524	ATP binding	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0067	F	From MGI
	GO:0005524	ATP binding	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR000719 InterPro:IPR017441 InterPro:IPR020747	F	From MGI
	GO:0005624	membrane fraction	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q07014	C	From MGI
	GO:0005634	nucleus	MGI:MGI:3694161 PMID:10713104^[10]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P07948	C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:3694161 PMID:10713104^[10]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005758	mitochondrial intermembrane space	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q07014	C	From MGI
	GO:0005794	Golgi apparatus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:E5RJ37	C	From MGI
	GO:0005886	plasma membrane	MGI:MGI:3844204 PMID:19064729^[13]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005886	plasma membrane	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q07014	C	From MGI
	GO:0005886	plasma membrane	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:E5RJ37	C	From MGI
	GO:0006468	protein phosphorylation	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266 InterPro:IPR020635	P	From MGI
	GO:0006954	inflammatory response	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0395	P	From MGI
	GO:0006974	response to DNA damage stimulus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P07948	P	From MGI
	GO:0007165	signal transduction	MGI:MGI:3694161 PMID:10713104^[10]	TAS: Traceable Author Statement		P	From MGI
	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P07948	P	From MGI
	GO:0008284	positive regulation of cell proliferation	MGI:MGI:2137179 PMID:11435302^[14]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0008284	positive regulation of cell proliferation	MGI:MGI:3694161 PMID:10713104^[10]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0008285	negative regulation of cell proliferation	MGI:MGI:3044099 PMID:14726379^[15]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0008285	negative regulation of cell proliferation	MGI:MGI:3664842 PMID:16116174^[16]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0008285	negative regulation of cell proliferation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P07948	P	From MGI
	GO:0009725	response to hormone stimulus	MGI:MGI:3694161 PMID:10713104^[10]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0010741	negative regulation of intracellular protein kinase cascade	MGI:MGI:2687173 PMID:14525964^[3]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0010976	positive regulation of neuron projection development	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P07948	P	From MGI
	GO:0014069	postsynaptic density	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q07014	C	From MGI
	GO:0016020	membrane	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0472	C	From MGI
	GO:0016301	kinase activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0418	F	From MGI
	GO:0016310	phosphorylation	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0418	P	From MGI
	GO:0016740	transferase activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0808	F	From MGI
	GO:0016772	transferase activity, transferring phosphorus-containing groups	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR011009	F	From MGI
	GO:0017124	SH3 domain binding	MGI:MGI:3844204 PMID:19064729^[13]	IPI: Inferred from Physical Interaction	UniProtKB:A7YB12	F	From MGI
	GO:0018108	peptidyl-tyrosine phosphorylation	MGI:MGI:1859033 PMID:10872802^[8]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0018108	peptidyl-tyrosine phosphorylation	MGI:MGI:2152233 PMID:11672542^[5]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0018108	peptidyl-tyrosine phosphorylation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P07948	P	From MGI
	GO:0018108	peptidyl-tyrosine phosphorylation	MGI:MGI:77358 PMID:7499277^[9]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0019899	enzyme binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q07014	F	From MGI
	GO:0030061	mitochondrial crista	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q07014	C	From MGI
	GO:0030097	hemopoiesis	MGI:MGI:2152233 PMID:11672542^[5]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0030218	erythrocyte differentiation	MGI:MGI:3694161 PMID:10713104^[10]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0030335	positive regulation of cell migration	MGI:MGI:2137179 PMID:11435302^[14]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0030889	negative regulation of B cell proliferation	MGI:MGI:894972 PMID:9252121^[1]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0031175	neuron projection development	MGI:MGI:3836888 PMID:19118221^[17]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0031625	ubiquitin protein ligase binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q07014	F	From MGI
	GO:0031663	lipopolysaccharide-mediated signaling pathway	MGI:MGI:4456928 PMID:20385881^[18]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0031966	mitochondrial membrane	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q07014	C	From MGI
	GO:0032403	protein complex binding	MGI:MGI:3844204 PMID:19064729^[13]	IPI: Inferred from Physical Interaction	UniProtKB:A7YB12 UniProtKB:P49710 UniProtKB:P62196 UniProtKB:Q8BZI0	F	From MGI
	GO:0032403	protein complex binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q07014	F	From MGI
	GO:0033003	regulation of mast cell activation	MGI:MGI:3703139 PMID:16272347^[2]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0033628	regulation of cell adhesion mediated by integrin	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P07948	P	From MGI
	GO:0034136	negative regulation of toll-like receptor 2 signaling pathway	MGI:MGI:4456928 PMID:20385881^[18]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0034144	negative regulation of toll-like receptor 4 signaling pathway	MGI:MGI:4456928 PMID:20385881^[18]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0034666	alpha2-beta1 integrin complex	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q07014	C	From MGI
	GO:0035556	intracellular signal transduction	MGI:MGI:85068 PMID:9000133^[7]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0042327	positive regulation of phosphorylation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q07014	P	From MGI
	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	MGI:MGI:3694161 PMID:10713104^[10]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0042541	hemoglobin biosynthetic process	MGI:MGI:3694161 PMID:10713104^[10]	TAS: Traceable Author Statement		P	From MGI
	GO:0042981	regulation of apoptotic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P07948	P	From MGI
	GO:0043208	glycosphingolipid binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q07014	F	From MGI
	GO:0043231	intracellular membrane-bounded organelle	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:E5RJ37	C	From MGI
	GO:0043304	regulation of mast cell degranulation	MGI:MGI:3703139 PMID:16272347^[2]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0043407	negative regulation of MAP kinase activity	MGI:MGI:894972 PMID:9252121^[1]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	MGI:MGI:5297796 PMID:8128248^[19]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0044325	ion channel binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P07948	F	From MGI
	GO:0045087	innate immune response	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0399	P	From MGI
	GO:0045121	membrane raft	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q07014	C	From MGI
	GO:0045121	membrane raft	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P07948	C	From MGI
	GO:0045646	regulation of erythrocyte differentiation	MGI:MGI:5297794 PMID:10594694^[20]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0046777	protein autophosphorylation	MGI:MGI:2152233 PMID:11672542^[5]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0046777	protein autophosphorylation	MGI:MGI:2385502 PMID:12192036^[21]	TAS: Traceable Author Statement		P	From MGI
	GO:0046777	protein autophosphorylation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P07948	P	From MGI
	GO:0046777	protein autophosphorylation	MGI:MGI:77358 PMID:7499277^[9]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0046777	protein autophosphorylation	MGI:MGI:85068 PMID:9000133^[7]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0050663	cytokine secretion	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q07014	P	From MGI
	GO:0050707	regulation of cytokine secretion	MGI:MGI:4456928 PMID:20385881^[18]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0050727	regulation of inflammatory response	MGI:MGI:3620486 PMID:16034130^[22]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	MGI:MGI:3769059 PMID:16249387^[12]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0050853	B cell receptor signaling pathway	MGI:MGI:77358 PMID:7499277^[9]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0050855	regulation of B cell receptor signaling pathway	MGI:MGI:2152233 PMID:11672542^[5]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0051219	phosphoprotein binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q07014	F	From MGI
	GO:0051272	positive regulation of cellular component movement	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P07948	P	From MGI
	GO:0051279	regulation of release of sequestered calcium ion into cytosol	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q07014	P	From MGI
	GO:0060252	positive regulation of glial cell proliferation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q07014	P	From MGI
	GO:0060369	positive regulation of Fc receptor mediated stimulatory signaling pathway	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q07014	P	From MGI
	GO:0070304	positive regulation of stress-activated protein kinase signaling cascade	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P07948	P	From MGI
	GO:0070372	regulation of ERK1 and ERK2 cascade	MGI:MGI:894972 PMID:9252121^[1]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0070373	negative regulation of ERK1 and ERK2 cascade	MGI:MGI:2687173 PMID:14525964^[3]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0070373	negative regulation of ERK1 and ERK2 cascade	MGI:MGI:3044099 PMID:14726379^[15]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0070447	positive regulation of oligodendrocyte progenitor proliferation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q07014	P	From MGI
	GO:0070667	negative regulation of mast cell proliferation	MGI:MGI:2687173 PMID:14525964^[3]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0070668	positive regulation of mast cell proliferation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P07948	P	From MGI
	GO:0071300	cellular response to retinoic acid	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P07948	P	From MGI
	GO:0090025	regulation of monocyte chemotaxis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P07948	P	From MGI
	GO:0090330	regulation of platelet aggregation	MGI:MGI:5298337 PMID:20189992^[4]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0097028	dendritic cell differentiation	MGI:MGI:3620486 PMID:16034130^[22]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:2000670	positive regulation of dendritic cell apoptotic process	MGI:MGI:3664842 PMID:16116174^[16]	IMP: Inferred from Mutant Phenotype		P	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Chan VW et al. (1997) Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation. Immunity 7: 69-81 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Xiao W et al. (2005) Positive and negative regulation of mast cell activation by Lyn via the FcepsilonRI. J Immunol 175: 6885-92 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Hernandez-Hansen V et al. (2004) The Src kinase Lyn is a negative regulator of mast cell proliferation. J Leukoc Biol 75: 143-51 PubMed GONUTS page
↑ ^4.0 ^4.1 Li Z et al. (2010) An important role of the SRC family kinase Lyn in stimulating platelet granule secretion. J Biol Chem 285: 12559-70 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Harder KW et al. (2001) Gain- and loss-of-function Lyn mutant mice define a critical inhibitory role for Lyn in the myeloid lineage. Immunity 15: 603-15 PubMed GONUTS page
↑ Wang J et al. (1996) Altered antigen receptor signaling and impaired Fas-mediated apoptosis of B cells in Lyn-deficient mice. J Exp Med 184: 831-8 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Costello PS et al. (1996) Critical role for the tyrosine kinase Syk in signalling through the high affinity IgE receptor of mast cells. Oncogene 13: 2595-605 PubMed GONUTS page
↑ ^8.0 ^8.1 Iseki M et al. (2000) Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins. Biochem Biophys Res Commun 272: 45-54 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Katagiri T et al. (1995) Selective regulation of Lyn tyrosine kinase by CD45 in immature B cells. J Biol Chem 270: 27987-90 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 ^10.7 ^10.8 ^10.9 Ingley E et al. (2000) HS1 interacts with Lyn and is critical for erythropoietin-induced differentiation of erythroid cells. J Biol Chem 275: 7887-93 PubMed GONUTS page
↑ Chew V & Lam KP (2007) Leupaxin negatively regulates B cell receptor signaling. J Biol Chem 282: 27181-91 PubMed GONUTS page
↑ ^12.0 ^12.1 Ahn E et al. (2006) LIME acts as a transmembrane adapter mediating BCR-dependent B-cell activation. Blood 107: 1521-7 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Samuels AL et al. (2009) Liar, a novel Lyn-binding nuclear/cytoplasmic shuttling protein that influences erythropoietin-induced differentiation. Blood 113: 3845-56 PubMed GONUTS page
↑ ^14.0 ^14.1 O'Laughlin-Bunner B et al. (2001) Lyn is required for normal stem cell factor-induced proliferation and chemotaxis of primary hematopoietic cells. Blood 98: 343-50 PubMed GONUTS page
↑ ^15.0 ^15.1 Lannutti BJ & Drachman JG (2004) Lyn tyrosine kinase regulates thrombopoietin-induced proliferation of hematopoietic cell lines and primary megakaryocytic progenitors. Blood 103: 3736-43 PubMed GONUTS page
↑ ^16.0 ^16.1 Chu CL & Lowell CA (2005) The Lyn tyrosine kinase differentially regulates dendritic cell generation and maturation. J Immunol 175: 2880-9 PubMed GONUTS page
↑ Ichikawa N et al. (2009) Binding of laminin-1 to monosialoganglioside GM1 in lipid rafts is crucial for neurite outgrowth. J Cell Sci 122: 289-99 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 ^18.3 Keck S et al. (2010) Activation of murine macrophages via TLR2 and TLR4 is negatively regulated by a Lyn/PI3K module and promoted by SHIP1. J Immunol 184: 5809-18 PubMed GONUTS page
↑ Pleiman CM et al. (1994) Activation of phosphatidylinositol-3' kinase by Src-family kinase SH3 binding to the p85 subunit. Science 263: 1609-12 PubMed GONUTS page
↑ Ochi H et al. (1999) Regulation of B-1 cell activation and its autoantibody production by Lyn kinase-regulated signallings. Immunology 98: 595-603 PubMed GONUTS page
↑ Craig AW & Greer PA (2002) Fer kinase is required for sustained p38 kinase activation and maximal chemotaxis of activated mast cells. Mol Cell Biol 22: 6363-74 PubMed GONUTS page
↑ ^22.0 ^22.1 Beavitt SJ et al. (2005) Lyn-deficient mice develop severe, persistent asthma: Lyn is a critical negative regulator of Th2 immunity. J Immunol 175: 1867-75 PubMed GONUTS page

[PMID:9252121-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Chan VW et al. (1997) Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation. Immunity 7: 69-81 PubMed GONUTS page

[PMID:16272347-1] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Xiao W et al. (2005) Positive and negative regulation of mast cell activation by Lyn via the FcepsilonRI. J Immunol 175: 6885-92 PubMed GONUTS page

[PMID:14525964-2] 3.0 ^3.1 ^3.2 ^3.3 Hernandez-Hansen V et al. (2004) The Src kinase Lyn is a negative regulator of mast cell proliferation. J Leukoc Biol 75: 143-51 PubMed GONUTS page

[PMID:20189992-3] 4.0 ^4.1 Li Z et al. (2010) An important role of the SRC family kinase Lyn in stimulating platelet granule secretion. J Biol Chem 285: 12559-70 PubMed GONUTS page

[PMID:11672542-4] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Harder KW et al. (2001) Gain- and loss-of-function Lyn mutant mice define a critical inhibitory role for Lyn in the myeloid lineage. Immunity 15: 603-15 PubMed GONUTS page

[PMID:9064343-5] Wang J et al. (1996) Altered antigen receptor signaling and impaired Fas-mediated apoptosis of B cells in Lyn-deficient mice. J Exp Med 184: 831-8 PubMed GONUTS page

[PMID:9000133-6] 7.0 ^7.1 ^7.2 Costello PS et al. (1996) Critical role for the tyrosine kinase Syk in signalling through the high affinity IgE receptor of mast cells. Oncogene 13: 2595-605 PubMed GONUTS page

[PMID:10872802-7] 8.0 ^8.1 Iseki M et al. (2000) Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins. Biochem Biophys Res Commun 272: 45-54 PubMed GONUTS page

[PMID:7499277-8] 9.0 ^9.1 ^9.2 ^9.3 Katagiri T et al. (1995) Selective regulation of Lyn tyrosine kinase by CD45 in immature B cells. J Biol Chem 270: 27987-90 PubMed GONUTS page

[PMID:10713104-9] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 ^10.7 ^10.8 ^10.9 Ingley E et al. (2000) HS1 interacts with Lyn and is critical for erythropoietin-induced differentiation of erythroid cells. J Biol Chem 275: 7887-93 PubMed GONUTS page

[PMID:17640867-10] Chew V & Lam KP (2007) Leupaxin negatively regulates B cell receptor signaling. J Biol Chem 282: 27181-91 PubMed GONUTS page

[PMID:16249387-11] 12.0 ^12.1 Ahn E et al. (2006) LIME acts as a transmembrane adapter mediating BCR-dependent B-cell activation. Blood 107: 1521-7 PubMed GONUTS page

[PMID:19064729-12] 13.0 ^13.1 ^13.2 Samuels AL et al. (2009) Liar, a novel Lyn-binding nuclear/cytoplasmic shuttling protein that influences erythropoietin-induced differentiation. Blood 113: 3845-56 PubMed GONUTS page

[PMID:11435302-13] 14.0 ^14.1 O'Laughlin-Bunner B et al. (2001) Lyn is required for normal stem cell factor-induced proliferation and chemotaxis of primary hematopoietic cells. Blood 98: 343-50 PubMed GONUTS page

[PMID:14726379-14] 15.0 ^15.1 Lannutti BJ & Drachman JG (2004) Lyn tyrosine kinase regulates thrombopoietin-induced proliferation of hematopoietic cell lines and primary megakaryocytic progenitors. Blood 103: 3736-43 PubMed GONUTS page

[PMID:16116174-15] 16.0 ^16.1 Chu CL & Lowell CA (2005) The Lyn tyrosine kinase differentially regulates dendritic cell generation and maturation. J Immunol 175: 2880-9 PubMed GONUTS page

[PMID:19118221-16] Ichikawa N et al. (2009) Binding of laminin-1 to monosialoganglioside GM1 in lipid rafts is crucial for neurite outgrowth. J Cell Sci 122: 289-99 PubMed GONUTS page

[PMID:20385881-17] 18.0 ^18.1 ^18.2 ^18.3 Keck S et al. (2010) Activation of murine macrophages via TLR2 and TLR4 is negatively regulated by a Lyn/PI3K module and promoted by SHIP1. J Immunol 184: 5809-18 PubMed GONUTS page

[PMID:8128248-18] Pleiman CM et al. (1994) Activation of phosphatidylinositol-3' kinase by Src-family kinase SH3 binding to the p85 subunit. Science 263: 1609-12 PubMed GONUTS page

[PMID:10594694-19] Ochi H et al. (1999) Regulation of B-1 cell activation and its autoantibody production by Lyn kinase-regulated signallings. Immunology 98: 595-603 PubMed GONUTS page

[PMID:12192036-20] Craig AW & Greer PA (2002) Fer kinase is required for sustained p38 kinase activation and maximal chemotaxis of activated mast cells. Mol Cell Biol 22: 6363-74 PubMed GONUTS page

[PMID:16034130-21] 22.0 ^22.1 Beavitt SJ et al. (2005) Lyn-deficient mice develop severe, persistent asthma: Lyn is a critical negative regulator of Th2 immunity. J Immunol 175: 1867-75 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Lyn ( synonyms: Hck-2 )
Protein Name(s)	Yamaguchi sarcoma viral (v-yes-1) oncogene homolog,
External Links
MGI	MGI:96892

MGI:Lyn

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