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MGI:Lta
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Lta ( synonyms: hlb382, LT, LT-(a), LT-alpha, LT(a), LTalpha, Ltx, lymphotoxin, lymphotoxin alpha, TNF beta, TNF-beta, Tnfb, Tnfsf1b ) | |
| Protein Name(s) | lymphotoxin A, | |
| External Links | ||
| MGI | MGI:104797 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0002876 |
positive regulation of chronic inflammatory response to antigenic stimulus |
MGI:MGI:3690573 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:104798 |
P |
From MGI |
||
| GO:0002925 |
positive regulation of humoral immune response mediated by circulating immunoglobulin |
MGI:MGI:3690573 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:104798 |
P |
From MGI |
||
| GO:0005125 |
cytokine activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0202 |
F |
From MGI |
||
| GO:0005164 |
tumor necrosis factor receptor binding |
MGI:MGI:1095831 |
TAS: Traceable Author Statement |
F |
From MGI |
|||
| GO:0005164 |
tumor necrosis factor receptor binding |
MGI:MGI:1098089 |
TAS: Traceable Author Statement |
F |
From MGI |
|||
| GO:0005164 |
tumor necrosis factor receptor binding |
MGI:MGI:1203431 |
TAS: Traceable Author Statement |
F |
From MGI |
|||
| GO:0005164 |
tumor necrosis factor receptor binding |
MGI:MGI:1343015 |
TAS: Traceable Author Statement |
F |
From MGI |
|||
| GO:0005164 |
tumor necrosis factor receptor binding |
MGI:MGI:53235 |
TAS: Traceable Author Statement |
F |
From MGI |
|||
| GO:0005164 |
tumor necrosis factor receptor binding |
MGI:MGI:65999 |
TAS: Traceable Author Statement |
F |
From MGI |
|||
| GO:0005164 |
tumor necrosis factor receptor binding |
MGI:MGI:87095 |
TAS: Traceable Author Statement |
F |
From MGI |
|||
| GO:0005576 |
extracellular region |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0964 |
C |
From MGI |
||
| GO:0005615 |
extracellular space |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0202 |
C |
From MGI |
||
| GO:0006927 |
transformed cell apoptotic process |
MGI:MGI:65999 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0006927 |
transformed cell apoptotic process |
MGI:MGI:75691 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0006954 |
inflammatory response |
MGI:MGI:1203431 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0006954 |
inflammatory response |
MGI:MGI:1343015 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0006954 |
inflammatory response |
MGI:MGI:53235 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0006954 |
inflammatory response |
MGI:MGI:65999 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0006954 |
inflammatory response |
MGI:MGI:87095 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0006955 |
immune response |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0006959 |
humoral immune response |
MGI:MGI:75691 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1860957 |
P |
From MGI |
||
| GO:0008283 |
cell proliferation |
MGI:MGI:75691 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0008284 |
positive regulation of cell proliferation |
MGI:MGI:65999 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0009987 |
cellular process |
MGI:MGI:53235 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016020 |
membrane |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0032729 |
positive regulation of interferon-gamma production |
MGI:MGI:3690573 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:104798 |
P |
From MGI |
||
| GO:0043065 |
positive regulation of apoptotic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0044130 |
negative regulation of growth of symbiont in host |
MGI:MGI:3690573 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:104798 |
P |
From MGI |
||
| GO:0048147 |
negative regulation of fibroblast proliferation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0048535 |
lymph node development |
MGI:MGI:1098089 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1860953 |
P |
From MGI |
||
| GO:0048535 |
lymph node development |
MGI:MGI:1203431 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1860954 |
P |
From MGI |
||
| GO:0048535 |
lymph node development |
MGI:MGI:1343015 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0048535 |
lymph node development |
MGI:MGI:65999 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857215 |
P |
From MGI |
||
| GO:0048535 |
lymph node development |
MGI:MGI:75691 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1860957 |
P |
From MGI |
||
| GO:0050830 |
defense response to Gram-positive bacterium |
MGI:MGI:3690573 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:104798 |
P |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Hultgren O et al. (1998) TNF/lymphotoxin-alpha double-mutant mice resist septic arthritis but display increased mortality in response to Staphylococcus aureus. J Immunol 161: 5937-42 PubMed GONUTS page
- ↑ Alimzhanov MB et al. (1997) Abnormal development of secondary lymphoid tissues in lymphotoxin beta-deficient mice. Proc Natl Acad Sci U S A 94: 9302-7 PubMed GONUTS page
- ↑ 3.0 3.1 Körner H et al. (1997) Distinct roles for lymphotoxin-alpha and tumor necrosis factor in organogenesis and spatial organization of lymphoid tissue. Eur J Immunol 27: 2600-9 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Sean Riminton D et al. (1998) Challenging cytokine redundancy: inflammatory cell movement and clinical course of experimental autoimmune encephalomyelitis are normal in lymphotoxin-deficient, but not tumor necrosis factor-deficient, mice. J Exp Med 187: 1517-28 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Matsumoto M et al. (1999) Involvement of distinct cellular compartments in the abnormal lymphoid organogenesis in lymphotoxin-alpha-deficient mice and alymphoplasia (aly) mice defined by the chimeric analysis. J Immunol 163: 1584-91 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Pfeffer K et al. (1993) Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection. Cell 73: 457-67 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 7.3 7.4 De Togni P et al. (1994) Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin. Science 264: 703-7 PubMed GONUTS page
- ↑ 8.0 8.1 Koni PA et al. (1997) Distinct roles in lymphoid organogenesis for lymphotoxins alpha and beta revealed in lymphotoxin beta-deficient mice. Immunity 6: 491-500 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 9.3 Banks TA et al. (1995) Lymphotoxin-alpha-deficient mice. Effects on secondary lymphoid organ development and humoral immune responsiveness. J Immunol 155: 1685-93 PubMed GONUTS page
