MGI:Lrrk2

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000165	MAPK cascade	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q5S007	P	From MGI
	GO:0000166	nucleotide binding	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0547	F	From MGI
	GO:0000186	activation of MAPKK activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q5S007	P	From MGI
	GO:0000187	activation of MAPK activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q5S007	P	From MGI
	GO:0001934	positive regulation of protein phosphorylation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q5S007	P	From MGI
	GO:0003924	GTPase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q5S007	F	From MGI
	GO:0004672	protein kinase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q5S007	F	From MGI
	GO:0004674	protein serine/threonine kinase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q5S007	F	From MGI
	GO:0004708	MAP kinase kinase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q5S007	F	From MGI
	GO:0005096	GTPase activator activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q5S007	F	From MGI
	GO:0005515	protein binding	MGI:MGI:4941068 PMID:21307259^[1]	IPI: Inferred from Physical Interaction	UniProtKB:P46460	F	From MGI
	GO:0005524	ATP binding	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0067	F	From MGI
	GO:0005524	ATP binding	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR000719 InterPro:IPR017441	F	From MGI
	GO:0005525	GTP binding	MGI:MGI:3664680 PMID:16980962^[2]	ISA: Inferred from Sequence Alignment	UniProtKB:Q17RV3	F	From MGI
	GO:0005525	GTP binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q5S007	F	From MGI
	GO:0005622	intracellular	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR013684 InterPro:IPR001806	C	From MGI
	GO:0005622	intracellular	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q5S007	C	From MGI
	GO:0005624	membrane fraction	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_001178718	C	From MGI
	GO:0005624	membrane fraction	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q5S007	C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_001178718	C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q5S007	C	From MGI
	GO:0005739	mitochondrion	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q5S007	C	From MGI
	GO:0005792	microsome	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_001178718	C	From MGI
	GO:0005802	trans-Golgi network	MGI:MGI:3711602 PMID:17341485^[3]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005886	plasma membrane	MGI:MGI:3711602 PMID:17341485^[3]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0006184	GTP catabolic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q5S007	P	From MGI
	GO:0006468	protein phosphorylation	MGI:MGI:3664680 PMID:16980962^[2]	ISA: Inferred from Sequence Alignment	UniProtKB:Q17RV3	P	From MGI
	GO:0006979	response to oxidative stress	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q5S007	P	From MGI
	GO:0007264	small GTPase mediated signal transduction	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR013684 InterPro:IPR001806	P	From MGI
	GO:0007406	negative regulation of neuroblast proliferation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q5S007	P	From MGI
	GO:0007528	neuromuscular junction development	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q5S007	P	From MGI
	GO:0008021	synaptic vesicle	MGI:MGI:3711602 PMID:17341485^[3]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0008340	determination of adult lifespan	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q5S007	P	From MGI
	GO:0010508	positive regulation of autophagy	MGI:MGI:4454597 PMID:20457918^[4]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0010942	positive regulation of cell death	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q5S007	P	From MGI
	GO:0014043	negative regulation of neuron maturation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q5S007	P	From MGI
	GO:0015631	tubulin binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q5S007	F	From MGI
	GO:0016020	membrane	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0472	C	From MGI
	GO:0016301	kinase activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0418	F	From MGI
	GO:0016310	phosphorylation	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0418	P	From MGI
	GO:0016740	transferase activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0808	F	From MGI
	GO:0016772	transferase activity, transferring phosphorus-containing groups	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR011009	F	From MGI
	GO:0017048	Rho GTPase binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q5S007	F	From MGI
	GO:0018105	peptidyl-serine phosphorylation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q5S007	P	From MGI
	GO:0018107	peptidyl-threonine phosphorylation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q5S007	P	From MGI
	GO:0019717	synaptosome	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_001178718	C	From MGI
	GO:0021772	olfactory bulb development	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q5S007	P	From MGI
	GO:0022028	tangential migration from the subventricular zone to the olfactory bulb	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q5S007	P	From MGI
	GO:0030424	axon	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_001178718	C	From MGI
	GO:0030425	dendrite	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_001178718	C	From MGI
	GO:0031398	positive regulation of protein ubiquitination	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q5S007	P	From MGI
	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	MGI:MGI:4454597 PMID:20457918^[4]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0032473	external side of mitochondrial outer membrane	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q5S007	C	From MGI
	GO:0034211	GTP-dependent protein kinase activity	MGI:MGI:3664680 PMID:16980962^[2]	ISA: Inferred from Sequence Alignment	UniProtKB:Q17RV3	F	From MGI
	GO:0034211	GTP-dependent protein kinase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q5S007	F	From MGI
	GO:0035564	regulation of kidney size	MGI:MGI:4454597 PMID:20457918^[4]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0035640	exploration behavior	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q5S007	P	From MGI
	GO:0040012	regulation of locomotion	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q5S007	P	From MGI
	GO:0042391	regulation of membrane potential	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q5S007	P	From MGI
	GO:0042803	protein homodimerization activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q5S007	F	From MGI
	GO:0043005	neuron projection	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q5S007	C	From MGI
	GO:0043025	neuronal cell body	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q5S007	C	From MGI
	GO:0043068	positive regulation of programmed cell death	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q5S007	P	From MGI
	GO:0043547	positive regulation of GTPase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q5S007	P	From MGI
	GO:0045121	membrane raft	MGI:MGI:3711602 PMID:17341485^[3]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0046777	protein autophosphorylation	MGI:MGI:3664680 PMID:16980962^[2]	ISA: Inferred from Sequence Alignment	UniProtKB:Q17RV3	P	From MGI
	GO:0046777	protein autophosphorylation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q5S007	P	From MGI
	GO:0048312	intracellular distribution of mitochondria	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q5S007	P	From MGI
	GO:0060161	positive regulation of dopamine receptor signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q5S007	P	From MGI
	GO:0061002	negative regulation of dendritic spine morphogenesis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q5S007	P	From MGI
	GO:0070997	neuron death	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q5S007	P	From MGI
	GO:2000173	negative regulation of branching morphogenesis of a nerve	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q5S007	P	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Piccoli G et al. (2011) LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool. J Neurosci 31: 2225-37 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Smith WW et al. (2006) Kinase activity of mutant LRRK2 mediates neuronal toxicity. Nat Neurosci 9: 1231-3 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Hatano T et al. (2007) Leucine-rich repeat kinase 2 associates with lipid rafts. Hum Mol Genet 16: 678-90 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Tong Y et al. (2010) Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice. Proc Natl Acad Sci U S A 107: 9879-84 PubMed GONUTS page

[PMID:21307259-0] Piccoli G et al. (2011) LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool. J Neurosci 31: 2225-37 PubMed GONUTS page

[PMID:16980962-1] 2.0 ^2.1 ^2.2 ^2.3 Smith WW et al. (2006) Kinase activity of mutant LRRK2 mediates neuronal toxicity. Nat Neurosci 9: 1231-3 PubMed GONUTS page

[PMID:17341485-2] 3.0 ^3.1 ^3.2 ^3.3 Hatano T et al. (2007) Leucine-rich repeat kinase 2 associates with lipid rafts. Hum Mol Genet 16: 678-90 PubMed GONUTS page

[PMID:20457918-3] 4.0 ^4.1 ^4.2 Tong Y et al. (2010) Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice. Proc Natl Acad Sci U S A 107: 9879-84 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Lrrk2 ( synonyms: cI-46, LOC381026 )
Protein Name(s)	leucine-rich repeat kinase 2,
External Links
MGI	MGI:1913975

MGI:Lrrk2

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