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MGI:Lrp8
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Lrp8 ( synonyms: apoER2, Lr8b ) | |
| Protein Name(s) | low density lipoprotein receptor-related protein 8, apolipoprotein e receptor, | |
| External Links | ||
| MGI | MGI:1340044 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3821675 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0001948 |
glycoprotein binding |
MGI:MGI:5306330 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0004872 |
receptor activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0675 |
F |
From MGI |
||
| GO:0005041 |
low-density lipoprotein receptor activity |
MGI:MGI:2136477 |
TAS: Traceable Author Statement |
F |
From MGI |
|||
| GO:0005041 |
low-density lipoprotein receptor activity |
MGI:MGI:2136753 |
TAS: Traceable Author Statement |
F |
From MGI |
|||
| GO:0005509 |
calcium ion binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3694290 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005576 |
extracellular region |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0964 |
C |
From MGI |
||
| GO:0005615 |
extracellular space |
MGI:MGI:3773783 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005624 |
membrane fraction |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:XP_001066578 |
C |
From MGI |
||
| GO:0005875 |
microtubule associated complex |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:XP_001066578 |
C |
From MGI |
||
| GO:0005886 |
plasma membrane |
MGI:MGI:2136477 |
TAS: Traceable Author Statement |
C |
From MGI |
|||
| GO:0005901 |
caveola |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006897 |
endocytosis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006898 |
receptor-mediated endocytosis |
MGI:MGI:2136477 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0006898 |
receptor-mediated endocytosis |
MGI:MGI:2136753 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0006898 |
receptor-mediated endocytosis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0008035 |
high-density lipoprotein particle binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:XP_001066578 |
F |
From MGI |
||
| GO:0014069 |
postsynaptic density |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:XP_001066578 |
C |
From MGI |
||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016021 |
integral to membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0812 |
C |
From MGI |
||
| GO:0019894 |
kinesin binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:XP_001066578 |
F |
From MGI |
||
| GO:0021541 |
ammon gyrus development |
MGI:MGI:3821675 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0021766 |
hippocampus development |
MGI:MGI:3769085 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:109520 |
P |
From MGI |
||
| GO:0021819 |
layer formation in cerebral cortex |
MGI:MGI:3769085 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:109520 |
P |
From MGI |
||
| GO:0030229 |
very-low-density lipoprotein particle receptor activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0030425 |
dendrite |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:XP_001066578 |
C |
From MGI |
||
| GO:0033267 |
axon part |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:XP_001066578 |
C |
From MGI |
||
| GO:0038025 |
reelin receptor activity |
MGI:MGI:3821675 |
IMP: Inferred from Mutant Phenotype |
F |
From MGI |
|||
| GO:0038026 |
reelin-mediated signaling pathway |
MGI:MGI:3821675 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0043025 |
neuronal cell body |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:XP_001066578 |
C |
From MGI |
||
| GO:0045860 |
positive regulation of protein kinase activity |
MGI:MGI:3629864 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:98935 |
P |
From MGI |
||
| GO:0048306 |
calcium-dependent protein binding |
MGI:MGI:5306330 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0050804 |
regulation of synaptic transmission |
MGI:MGI:3821675 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:1900006 |
positive regulation of dendrite development |
MGI:MGI:3821675 |
IGI: Inferred from Genetic Interaction |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Fish KN & Krucker T (2008) Functional consequences of hippocampal neuronal ectopia in the apolipoprotein E receptor-2 knockout mouse. Neurobiol Dis 32: 391-401 PubMed GONUTS page
- ↑ 2.0 2.1 D'Arcangelo G et al. (1999) Reelin is a ligand for lipoprotein receptors. Neuron 24: 471-9 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Brandes C et al. (2001) Alternative splicing in the ligand binding domain of mouse ApoE receptor-2 produces receptor variants binding reelin but not alpha 2-macroglobulin. J Biol Chem 276: 22160-9 PubMed GONUTS page
- ↑ 4.0 4.1 Kim HJ et al. (1998) Evolution of the apolipoprotein E receptor 2 gene by exon loss. J Biochem 124: 451-6 PubMed GONUTS page
- ↑ Hoe HS et al. (2006) Apolipoprotein E receptor 2 interactions with the N-methyl-D-aspartate receptor. J Biol Chem 281: 3425-31 PubMed GONUTS page
- ↑ Hoe HS & Rebeck GW (2005) Regulation of ApoE receptor proteolysis by ligand binding. Brain Res Mol Brain Res 137: 31-9 PubMed GONUTS page
- ↑ 7.0 7.1 Zhang G et al. (2007) The Pafah1b complex interacts with the reelin receptor VLDLR. PLoS One 2: e252 PubMed GONUTS page
- ↑ Bock HH & Herz J (2003) Reelin activates SRC family tyrosine kinases in neurons. Curr Biol 13: 18-26 PubMed GONUTS page
