GONUTS is under stress! The website is currently experiencing long-wait times and frequent time-outs due to the record number of students, groups, and annotations related to CACAO this semester. We are currently working on increasing performance -- please accept our apologies for the technical difficulties.
You can help reduce stress on the server by:
- not reloading pages frequently - this just adds
- opening links in new windows (so you can read the old page)
MGI:Lrp1
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Lrp1 ( synonyms: A2mr, CD91 ) | |
| Protein Name(s) | low density lipoprotein receptor-related protein 1, | |
| External Links | ||
| MGI | MGI:96828 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0002020 |
protease binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001123962 |
F |
From MGI |
||
| GO:0004872 |
receptor activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0675 |
F |
From MGI |
||
| GO:0005509 |
calcium ion binding |
MGI:MGI:77596 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3687813 |
IPI: Inferred from Physical Interaction |
UniProtKB:P97318 |
F |
From MGI |
||
| GO:0005515 |
protein binding |
MGI:MGI:3762243 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3762423 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3847372 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:4359331 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:5306561 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005624 |
membrane fraction |
MGI:MGI:3042677 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0539 |
C |
From MGI |
||
| GO:0005737 |
cytoplasm |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0963 |
C |
From MGI |
||
| GO:0005768 |
endosome |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001123962 |
C |
From MGI |
||
| GO:0005886 |
plasma membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-1003 |
C |
From MGI |
||
| GO:0005887 |
integral to plasma membrane |
MGI:MGI:77596 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005905 |
coated pit |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0168 |
C |
From MGI |
||
| GO:0006897 |
endocytosis |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0254 |
P |
From MGI |
||
| GO:0006898 |
receptor-mediated endocytosis |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001123962 |
P |
From MGI |
||
| GO:0006898 |
receptor-mediated endocytosis |
MGI:MGI:5139915 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007205 |
activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001123962 |
P |
From MGI |
||
| GO:0007275 |
multicellular organismal development |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0217 |
P |
From MGI |
||
| GO:0008203 |
cholesterol metabolic process |
MGI:MGI:3762423 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2180880 |
P |
From MGI |
||
| GO:0008283 |
cell proliferation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001123962 |
P |
From MGI |
||
| GO:0010875 |
positive regulation of cholesterol efflux |
MGI:MGI:4358638 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0014912 |
negative regulation of smooth muscle cell migration |
MGI:MGI:4365879 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016021 |
integral to membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0812 |
C |
From MGI |
||
| GO:0030136 |
clathrin-coated vesicle |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001123962 |
C |
From MGI |
||
| GO:0030178 |
negative regulation of Wnt receptor signaling pathway |
MGI:MGI:3619629 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0030425 |
dendrite |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001123962 |
C |
From MGI |
||
| GO:0032370 |
positive regulation of lipid transport |
MGI:MGI:4358638 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0032374 |
regulation of cholesterol transport |
MGI:MGI:4358638 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0032403 |
protein complex binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0032429 |
regulation of phospholipase A2 activity |
MGI:MGI:4358638 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0032956 |
regulation of actin cytoskeleton organization |
MGI:MGI:4365879 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0034185 |
apolipoprotein binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0035909 |
aorta morphogenesis |
MGI:MGI:4365879 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0043025 |
neuronal cell body |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001123962 |
C |
From MGI |
||
| GO:0043277 |
apoptotic cell clearance |
MGI:MGI:3618422 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0045768 |
positive regulation of anti-apoptosis |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001123962 |
P |
From MGI |
||
| GO:0046872 |
metal ion binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0479 |
F |
From MGI |
||
| GO:0048471 |
perinuclear region of cytoplasm |
MGI:MGI:3847372 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0051222 |
positive regulation of protein transport |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001123962 |
P |
From MGI |
||
| GO:2000587 |
negative regulation of platelet-derived growth factor receptor-beta signaling pathway |
MGI:MGI:4365879 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Herz J et al. (1988) Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor. EMBO J 7: 4119-27 PubMed GONUTS page
- ↑ Gotthardt M et al. (2000) Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction. J Biol Chem 275: 25616-24 PubMed GONUTS page
- ↑ Mameza MG et al. (2007) Characterization of the adaptor protein ARH expression in the brain and ARH molecular interactions. J Neurochem 103: 927-41 PubMed GONUTS page
- ↑ 4.0 4.1 Liu Q et al. (2007) Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1. Neuron 56: 66-78 PubMed GONUTS page
- ↑ 5.0 5.1 Spoelgen R et al. (2009) Interaction of the apolipoprotein E receptors low density lipoprotein receptor-related protein and sorLA/LR11. Neuroscience 158: 1460-8 PubMed GONUTS page
- ↑ Fernández E et al. (2009) Targeted tandem affinity purification of PSD-95 recovers core postsynaptic complexes and schizophrenia susceptibility proteins. Mol Syst Biol 5: 269 PubMed GONUTS page
- ↑ Kajiwara Y et al. (2010) Extensive proteomic screening identifies the obesity-related NYGGF4 protein as a novel LRP1-interactor, showing reduced expression in early Alzheimer's disease. Mol Neurodegener 5: 1 PubMed GONUTS page
- ↑ Marschang P et al. (2004) Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1. Mol Cell Biol 24: 3782-93 PubMed GONUTS page
- ↑ Ranganathan S et al. (2011) LRAD3, a novel low-density lipoprotein receptor family member that modulates amyloid precursor protein trafficking. J Neurosci 31: 10836-46 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 10.3 Zhou L et al. (2009) LRP1 controls cPLA2 phosphorylation, ABCA1 expression and cellular cholesterol export. PLoS One 4: e6853 PubMed GONUTS page
- ↑ 11.0 11.1 11.2 11.3 Zhou L et al. (2009) LRP1 regulates architecture of the vascular wall by controlling PDGFRbeta-dependent phosphatidylinositol 3-kinase activation. PLoS One 4: e6922 PubMed GONUTS page
- ↑ Johnson EB et al. (2005) Abnormal development of the apical ectodermal ridge and polysyndactyly in Megf7-deficient mice. Hum Mol Genet 14: 3523-38 PubMed GONUTS page
- ↑ Monks J et al. (2005) Epithelial cells as phagocytes: apoptotic epithelial cells are engulfed by mammary alveolar epithelial cells and repress inflammatory mediator release. Cell Death Differ 12: 107-14 PubMed GONUTS page
