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MGI:Lox
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Lox ( synonyms: ras recision gene (rrg), TSC-160 ) | |
| Protein Name(s) | lysyl oxidase, | |
| External Links | ||
| MGI | MGI:96817 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001568 |
blood vessel development |
MGI:MGI:3609311 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3610732 |
P |
From MGI |
||
| GO:0004720 |
protein-lysine 6-oxidase activity |
MGI:MGI:3029035 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004720 |
protein-lysine 6-oxidase activity |
MGI:MGI:3604822 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004720 |
protein-lysine 6-oxidase activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0004720 |
protein-lysine 6-oxidase activity |
MGI:MGI:54254 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004720 |
protein-lysine 6-oxidase activity |
MGI:MGI:54357 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005507 |
copper ion binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3616956 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005576 |
extracellular region |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0964 |
C |
From MGI |
||
| GO:0005578 |
proteinaceous extracellular matrix |
MGI:MGI:1101283 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005578 |
proteinaceous extracellular matrix |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005581 |
collagen |
MGI:MGI:65985 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0009725 |
response to hormone stimulus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0016491 |
oxidoreductase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0560 |
F |
From MGI |
||
| GO:0016641 |
oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0030199 |
collagen fibril organization |
MGI:MGI:3604446 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3610732 |
P |
From MGI |
||
| GO:0030199 |
collagen fibril organization |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030324 |
lung development |
MGI:MGI:3604822 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3610732 |
P |
From MGI |
||
| GO:0042060 |
wound healing |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0046872 |
metal ion binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0479 |
F |
From MGI |
||
| GO:0048251 |
elastic fiber assembly |
MGI:MGI:3604822 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3610732 |
P |
From MGI |
||
| GO:0048251 |
elastic fiber assembly |
MGI:MGI:3609311 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3610732 |
P |
From MGI |
||
| GO:0048251 |
elastic fiber assembly |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0048545 |
response to steroid hormone stimulus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Mäki JM et al. (2002) Inactivation of the lysyl oxidase gene Lox leads to aortic aneurysms, cardiovascular dysfunction, and perinatal death in mice. Circulation 106: 2503-9 PubMed GONUTS page
- ↑ Li PA et al. (2004) Up-regulation and altered distribution of lysyl oxidase in the central nervous system of mutant SOD1 transgenic mouse model of amyotrophic lateral sclerosis. Brain Res Mol Brain Res 120: 115-22 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Mäki JM et al. (2005) Lysyl oxidase is essential for normal development and function of the respiratory system and for the integrity of elastic and collagen fibers in various tissues. Am J Pathol 167: 927-36 PubMed GONUTS page
- ↑ Rowe DW et al. (1977) Decreased lysyl oxidase activity in the aneurysm-prone, mottled mouse. J Biol Chem 252: 939-42 PubMed GONUTS page
- ↑ Starcher BC et al. (1977) Lysyl oxidase deficiency in lung and fibroblasts from mice with hereditary emphysema. Biochem Biophys Res Commun 78: 706-12 PubMed GONUTS page
- ↑ Thomassin L et al. (2005) The Pro-regions of lysyl oxidase and lysyl oxidase-like 1 are required for deposition onto elastic fibers. J Biol Chem 280: 42848-55 PubMed GONUTS page
- ↑ Macauley SP et al. (1997) Extracellular-matrix gene expression during mouse submandibular gland development. Arch Oral Biol 42: 443-54 PubMed GONUTS page
- ↑ Sommer P et al. (1993) Transient expression of lysyl oxidase by liver myofibroblasts in murine schistosomiasis. Lab Invest 69: 460-70 PubMed GONUTS page
- ↑ Descamps O et al. (2005) Mitochondrial production of reactive oxygen species and incidence of age-associated lymphoma in OF1 mice: effect of alternate-day fasting. Mech Ageing Dev 126: 1185-91 PubMed GONUTS page
