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MGI:Lingo1

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Contents

Species (Taxon ID) Mus musculus (house mouse) (taxon:10090)
Gene Name(s) Lingo1 ( synonyms: LERN1, LINGO-1, Lrrn6a, UNQ201 )
Protein Name(s) leucine rich repeat and Ig domain containing 1,
External Links
MGI MGI:1915522

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005154

epidermal growth factor receptor binding

MGI:MGI:3722980
PMID:17726113[1]

IPI: Inferred from Physical Interaction

UniProtKB:Q01279

F

From MGI

GO:0005515

protein binding

MGI:MGI:3829123
PMID:17934213[2]

IPI: Inferred from Physical Interaction

UniProtKB:P12023

F

From MGI

GO:0005622

intracellular

MGI:MGI:3722980
PMID:17726113[1]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005886

plasma membrane

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-1003

C

From MGI

GO:0016020

membrane

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

From MGI

GO:0016021

integral to membrane

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0812

C

From MGI

GO:0021954

central nervous system neuron development

MGI:MGI:3722980
PMID:17726113[1]

IDA: Inferred from Direct Assay

P

From MGI

GO:0021954

central nervous system neuron development

MGI:MGI:3722980
PMID:17726113[1]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3623893

P

From MGI

GO:0031175

neuron projection development

MGI:MGI:3722980
PMID:17726113[1]

IDA: Inferred from Direct Assay

P

From MGI

GO:0043491

protein kinase B signaling cascade

MGI:MGI:3722980
PMID:17726113[1]

IDA: Inferred from Direct Assay

P

From MGI

GO:0048715

negative regulation of oligodendrocyte differentiation

MGI:MGI:3581086
PMID:15895088[3]

IMP: Inferred from Mutant Phenotype

P

From MGI


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 1.2 1.3 1.4 1.5 Inoue H et al. (2007) Inhibition of the leucine-rich repeat protein LINGO-1 enhances survival, structure, and function of dopaminergic neurons in Parkinson's disease models. Proc Natl Acad Sci U S A 104: 14430-5 PubMed GONUTS page
  2. Bai Y et al. (2008) The in vivo brain interactome of the amyloid precursor protein. Mol Cell Proteomics 7: 15-34 PubMed GONUTS page
  3. Mi S et al. (2005) LINGO-1 negatively regulates myelination by oligodendrocytes. Nat Neurosci 8: 745-51 PubMed GONUTS page
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