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MGI:Lif
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Lif | |
| Protein Name(s) | leukemia inhibitory factor, | |
| External Links | ||
| MGI | MGI:96787 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001974 |
blood vessel remodeling |
MGI:MGI:3640953 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:96432 |
P |
From MGI |
||
| GO:0005102 |
receptor binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005125 |
cytokine activity |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005125 |
cytokine activity |
MGI:MGI:3036919 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005125 |
cytokine activity |
MGI:MGI:82525 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005146 |
leukemia inhibitory factor receptor binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005146 |
leukemia inhibitory factor receptor binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005146 |
leukemia inhibitory factor receptor binding |
MGI:MGI:69257 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005576 |
extracellular region |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0964 |
C |
From MGI |
||
| GO:0005576 |
extracellular region |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0005615 |
extracellular space |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006955 |
immune response |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0007566 |
embryo implantation |
MGI:MGI:82525 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007566 |
embryo implantation |
MGI:MGI:82525 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2177780 |
P |
From MGI |
||
| GO:0008083 |
growth factor activity |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0008083 |
growth factor activity |
MGI:MGI:82525 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2177780 |
F |
From MGI |
||
| GO:0008284 |
positive regulation of cell proliferation |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0008284 |
positive regulation of cell proliferation |
MGI:MGI:82525 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2177780 |
P |
From MGI |
||
| GO:0008285 |
negative regulation of cell proliferation |
MGI:MGI:3640953 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:96432 |
P |
From MGI |
||
| GO:0010976 |
positive regulation of neuron projection development |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0016525 |
negative regulation of angiogenesis |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0019827 |
stem cell maintenance |
MGI:MGI:3530919 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0019827 |
stem cell maintenance |
MGI:MGI:3530919 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1201791 |
P |
From MGI |
||
| GO:0030324 |
lung development |
MGI:MGI:3640953 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:96432 |
P |
From MGI |
||
| GO:0031100 |
organ regeneration |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0033138 |
positive regulation of peptidyl-serine phosphorylation |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0033141 |
positive regulation of peptidyl-serine phosphorylation of STAT protein |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042503 |
tyrosine phosphorylation of Stat3 protein |
MGI:MGI:3036919 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0042511 |
positive regulation of tyrosine phosphorylation of Stat1 protein |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042517 |
positive regulation of tyrosine phosphorylation of Stat3 protein |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043410 |
positive regulation of MAPK cascade |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045595 |
regulation of cell differentiation |
MGI:MGI:3609466 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1201791 |
P |
From MGI |
||
| GO:0045651 |
positive regulation of macrophage differentiation |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045835 |
negative regulation of meiosis |
MGI:MGI:1929792 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3640953 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:96432 |
P |
From MGI |
||
| GO:0046697 |
decidualization |
MGI:MGI:82525 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0046697 |
decidualization |
MGI:MGI:82525 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2177780 |
P |
From MGI |
||
| GO:0046888 |
negative regulation of hormone secretion |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0048286 |
lung alveolus development |
MGI:MGI:3640953 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:96432 |
P |
From MGI |
||
| GO:0048644 |
muscle organ morphogenesis |
MGI:MGI:3575352 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2181618 |
P |
From MGI |
||
| GO:0048666 |
neuron development |
MGI:MGI:3575352 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:88439 |
P |
From MGI |
||
| GO:0048708 |
astrocyte differentiation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0048711 |
positive regulation of astrocyte differentiation |
MGI:MGI:1343608 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0048861 |
leukemia inhibitory factor signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0050731 |
positive regulation of peptidyl-tyrosine phosphorylation |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0051461 |
positive regulation of corticotropin secretion |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0060041 |
retina development in camera-type eye |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0060135 |
maternal process involved in female pregnancy |
MGI:MGI:82525 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2177780 |
P |
From MGI |
||
| GO:0060290 |
transdifferentiation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0060426 |
lung vasculature development |
MGI:MGI:3640953 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:96432 |
P |
From MGI |
||
| GO:0060463 |
lung lobe morphogenesis |
MGI:MGI:3640953 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:96432 |
P |
From MGI |
||
| GO:0060707 |
trophoblast giant cell differentiation |
MGI:MGI:3609466 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1201791 |
P |
From MGI |
||
| GO:0060708 |
spongiotrophoblast differentiation |
MGI:MGI:3609466 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1201791 |
P |
From MGI |
||
| GO:0070373 |
negative regulation of ERK1 and ERK2 cascade |
MGI:MGI:3640953 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:96432 |
P |
From MGI |
||
| GO:0072108 |
positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0072307 |
regulation of metanephric nephron tubule epithelial cell differentiation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Moreno-Barriuso N et al. (2006) Alterations in alveolar epithelium differentiation and vasculogenesis in lungs of LIF/IGF-I double deficient embryos. Dev Dyn 235: 2040-50 PubMed GONUTS page
- ↑ 2.0 2.1 Auernhammer CJ et al. (2004) The oncostatin M receptor/gp130 ligand murine oncostatin M induces apoptosis in adrenocortical Y-1 tumor cells. J Endocrinol 180: 479-86 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 Stewart CL et al. (1992) Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor. Nature 359: 76-9 PubMed GONUTS page
- ↑ Hilton DJ et al. (1994) Cloning of a murine IL-11 receptor alpha-chain; requirement for gp130 for high affinity binding and signal transduction. EMBO J 13: 4765-75 PubMed GONUTS page
- ↑ 5.0 5.1 Li Y et al. (2005) Murine embryonic stem cell differentiation is promoted by SOCS-3 and inhibited by the zinc finger transcription factor Klf4. Blood 105: 635-7 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Robb L et al. (2005) Genetic reduction of embryonic leukemia-inhibitory factor production rescues placentation in SOCS3-null embryos but does not prevent inflammatory disease. Proc Natl Acad Sci U S A 102: 16333-8 PubMed GONUTS page
- ↑ Chuma S & Nakatsuji N (2001) Autonomous transition into meiosis of mouse fetal germ cells in vitro and its inhibition by gp130-mediated signaling. Dev Biol 229: 468-79 PubMed GONUTS page
- ↑ 8.0 8.1 Holtmann B et al. (2005) Triple knock-out of CNTF, LIF, and CT-1 defines cooperative and distinct roles of these neurotrophic factors for motoneuron maintenance and function. J Neurosci 25: 1778-87 PubMed GONUTS page
- ↑ Nakashima K et al. (1999) Astrocyte differentiation mediated by LIF in cooperation with BMP2. FEBS Lett 457: 43-6 PubMed GONUTS page
