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MGI:Lias
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Lias ( synonyms: 7a5ex, MGC7254, mLip1 ) | |
| Protein Name(s) | lipoic acid synthetase, | |
| External Links | ||
| MGI | MGI:1934604 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001843 |
neural tube closure |
MGI:MGI:3577662 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3578174 |
P |
From MGI |
||
| GO:0003824 |
catalytic activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005739 |
mitochondrion |
MGI:MGI:2135807 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005739 |
mitochondrion |
MGI:MGI:2682130 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005739 |
mitochondrion |
MGI:MGI:3852644 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0006954 |
inflammatory response |
MGI:MGI:3826894 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3604218 |
P |
From MGI |
||
| GO:0006979 |
response to oxidative stress |
MGI:MGI:3826894 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3604218 |
P |
From MGI |
||
| GO:0008152 |
metabolic process |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0808 |
P |
From MGI |
||
| GO:0008152 |
metabolic process |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0009107 |
lipoate biosynthetic process |
MGI:MGI:2135807 |
IGI: Inferred from Genetic Interaction |
P |
From MGI |
|||
| GO:0016740 |
transferase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0808 |
F |
From MGI |
||
| GO:0016992 |
lipoate synthase activity |
MGI:MGI:2135807 |
IGI: Inferred from Genetic Interaction |
F |
From MGI |
|||
| GO:0032496 |
response to lipopolysaccharide |
MGI:MGI:3826894 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3604218 |
P |
From MGI |
||
| GO:0046872 |
metal ion binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0479 |
F |
From MGI |
||
| GO:0051536 |
iron-sulfur cluster binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0411 |
F |
From MGI |
||
| GO:0051536 |
iron-sulfur cluster binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0051539 |
4 iron, 4 sulfur cluster binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0004 |
F |
From MGI |
||
| GO:0051539 |
4 iron, 4 sulfur cluster binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ García-García MJ et al. (2005) Analysis of mouse embryonic patterning and morphogenesis by forward genetics. Proc Natl Acad Sci U S A 102: 5913-9 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Morikawa T et al. (2001) Do mammalian cells synthesize lipoic acid? Identification of a mouse cDNA encoding a lipoic acid synthase located in mitochondria. FEBS Lett 498: 16-21 PubMed GONUTS page
- ↑ Mootha VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell 115: 629-40 PubMed GONUTS page
- ↑ Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134: 112-23 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Yi X et al. (2009) Mice with heterozygous deficiency of lipoic acid synthase have an increased sensitivity to lipopolysaccharide-induced tissue injury. J Leukoc Biol 85: 146-53 PubMed GONUTS page
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