MGI:Lep

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	MGI:MGI:4889014 PMID:21234744^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0001542	ovulation from ovarian follicle	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P50596	P	From MGI
	GO:0001890	placenta development	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P41159	P	From MGI
	GO:0001932	regulation of protein phosphorylation	MGI:MGI:4889014 PMID:21234744^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0002021	response to dietary excess	MGI:MGI:3721169 PMID:12177191^[2]	IGI: Inferred from Genetic Interaction	MGI:MGI:1343180	P	From MGI
	GO:0002021	response to dietary excess	MGI:MGI:3770192 PMID:16141392^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856424	P	From MGI
	GO:0002021	response to dietary excess	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P50596	P	From MGI
	GO:0005179	hormone activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P50596	F	From MGI
	GO:0005515	protein binding	MGI:MGI:86341 PMID:9102398^[4]	IPI: Inferred from Physical Interaction	UniProtKB:O89013	F	From MGI
	GO:0005576	extracellular region	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0964	C	From MGI
	GO:0005576	extracellular region	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR000065	C	From MGI
	GO:0005615	extracellular space	MGI:MGI:1203479 PMID:9590691^[5]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:3761982 PMID:17693256^[6]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P50596	C	From MGI
	GO:0005615	extracellular space	MGI:MGI:4868567 PMID:20952387^[7]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005622	intracellular	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P50596	C	From MGI
	GO:0005623	cell	MGI:MGI:3770192 PMID:16141392^[3]	IGI: Inferred from Genetic Interaction	MGI:MGI:1343180	C	From MGI
	GO:0006006	glucose metabolic process	MGI:MGI:2449716 PMID:12540600^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856424	P	From MGI
	GO:0006111	regulation of gluconeogenesis	MGI:MGI:3769319 PMID:16513828^[9]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856424	P	From MGI
	GO:0006112	energy reserve metabolic process	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P50596	P	From MGI
	GO:0006114	glycerol biosynthetic process	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P50596	P	From MGI
	GO:0006629	lipid metabolic process	MGI:MGI:2673743 PMID:12815040^[10]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856424	P	From MGI
	GO:0007165	signal transduction	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR000065	P	From MGI
	GO:0007260	tyrosine phosphorylation of STAT protein	MGI:MGI:4889014 PMID:21234744^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0008083	growth factor activity	MGI:MGI:86079 PMID:9057630^[11]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0008203	cholesterol metabolic process	MGI:MGI:3588626 PMID:15995171^[12]	IGI: Inferred from Genetic Interaction	MGI:MGI:88049	P	From MGI
	GO:0008206	bile acid metabolic process	MGI:MGI:2386518 PMID:12114517^[13]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0008217	regulation of blood pressure	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P50596	P	From MGI
	GO:0008284	positive regulation of cell proliferation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P50596	P	From MGI
	GO:0008343	adult feeding behavior	MGI:MGI:1203479 PMID:9590691^[5]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0009062	fatty acid catabolic process	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P50596	P	From MGI
	GO:0009892	negative regulation of metabolic process	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P50596	P	From MGI
	GO:0019222	regulation of metabolic process	MGI:MGI:3521560 PMID:12925742^[14]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856424	P	From MGI
	GO:0021954	central nervous system neuron development	MGI:MGI:1351081 PMID:10592285^[15]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856424	P	From MGI
	GO:0030073	insulin secretion	MGI:MGI:3770192 PMID:16141392^[3]	IGI: Inferred from Genetic Interaction	MGI:MGI:1343180	P	From MGI
	GO:0030300	regulation of intestinal cholesterol absorption	MGI:MGI:2386518 PMID:12114517^[13]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0032099	negative regulation of appetite	MGI:MGI:1203479 PMID:9590691^[5]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0032868	response to insulin stimulus	MGI:MGI:3770192 PMID:16141392^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856424	P	From MGI
	GO:0033210	leptin-mediated signaling pathway	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P50596	P	From MGI
	GO:0035556	intracellular signal transduction	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P50596	P	From MGI
	GO:0035630	bone mineralization involved in bone maturation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P50596	P	From MGI
	GO:0042307	positive regulation of protein import into nucleus	MGI:MGI:4889014 PMID:21234744^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0042445	hormone metabolic process	MGI:MGI:3769319 PMID:16513828^[9]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856424	P	From MGI
	GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P50596	P	From MGI
	GO:0042755	eating behavior	MGI:MGI:1855732 PMID:10802666^[16]	IGI: Inferred from Genetic Interaction	MGI:MGI:98735	P	From MGI
	GO:0043066	negative regulation of apoptotic process	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P50596	P	From MGI
	GO:0043270	positive regulation of ion transport	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P50596	P	From MGI
	GO:0043410	positive regulation of MAPK cascade	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P50596	P	From MGI
	GO:0045639	positive regulation of myeloid cell differentiation	MGI:MGI:86079 PMID:9057630^[11]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045906	negative regulation of vasoconstriction	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P50596	P	From MGI
	GO:0046427	positive regulation of JAK-STAT cascade	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P50596	P	From MGI
	GO:0046427	positive regulation of JAK-STAT cascade	MGI:MGI:4889014 PMID:21234744^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0046628	positive regulation of insulin receptor signaling pathway	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P50596	P	From MGI
	GO:0048639	positive regulation of developmental growth	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P41159	P	From MGI
	GO:0050796	regulation of insulin secretion	MGI:MGI:3769319 PMID:16513828^[9]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856424	P	From MGI
	GO:0050810	regulation of steroid biosynthetic process	MGI:MGI:3769319 PMID:16513828^[9]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856424	P	From MGI
	GO:0050901	leukocyte tethering or rolling	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P50596	P	From MGI
	GO:0051428	peptide hormone receptor binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P50596	F	From MGI
	GO:0060587	regulation of lipoprotein lipid oxidation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P50596	P	From MGI
	GO:0060612	adipose tissue development	MGI:MGI:1355047 PMID:10742101^[17]	IGI: Inferred from Genetic Interaction	MGI:MGI:101761	P	From MGI
	GO:0061037	negative regulation of cartilage development	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P50596	P	From MGI
	GO:0070093	negative regulation of glucagon secretion	MGI:MGI:4889014 PMID:21234744^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:2000366	positive regulation of STAT protein import into nucleus	MGI:MGI:4889014 PMID:21234744^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:2000486	negative regulation of glutamine transport	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P50596	P	From MGI
	GO:2000491	positive regulation of hepatic stellate cell activation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P50596	P	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Marroquí L et al. (2011) Leptin downregulates expression of the gene encoding glucagon in alphaTC1-9 cells and mouse islets. Diabetologia 54: 843-51 PubMed GONUTS page
↑ Hahm S et al. (2002) VGF is required for obesity induced by diet, gold thioglucose treatment, and agouti and is differentially regulated in pro-opiomelanocortin- and neuropeptide Y-containing arcuate neurons in response to fasting. J Neurosci 22: 6929-38 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Watson E et al. (2005) VGF ablation blocks the development of hyperinsulinemia and hyperglycemia in several mouse models of obesity. Endocrinology 146: 5151-63 PubMed GONUTS page
↑ Tartaglia LA (1997) The leptin receptor. J Biol Chem 272: 6093-6 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Kristensen P et al. (1998) Hypothalamic CART is a new anorectic peptide regulated by leptin. Nature 393: 72-6 PubMed GONUTS page
↑ Lee NK et al. (2007) Endocrine regulation of energy metabolism by the skeleton. Cell 130: 456-69 PubMed GONUTS page
↑ Peterson JM et al. (2010) C1q/TNF-related protein-3 (CTRP3), a novel adipokine that regulates hepatic glucose output. J Biol Chem 285: 39691-701 PubMed GONUTS page
↑ Maeda K et al. (2003) Role of the fatty acid binding protein mal1 in obesity and insulin resistance. Diabetes 52: 300-7 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Luque RM & Kineman RD (2006) Impact of obesity on the growth hormone axis: evidence for a direct inhibitory effect of hyperinsulinemia on pituitary function. Endocrinology 147: 2754-63 PubMed GONUTS page
↑ Miyazaki M et al. (2003) Identification and characterization of murine SCD4, a novel heart-specific stearoyl-CoA desaturase isoform regulated by leptin and dietary factors. J Biol Chem 278: 33904-11 PubMed GONUTS page
↑ ^11.0 ^11.1 Mikhail AA et al. (1997) Leptin stimulates fetal and adult erythroid and myeloid development. Blood 89: 1507-12 PubMed GONUTS page
↑ Gruen ML et al. (2005) Persistence of high density lipoprotein particles in obese mice lacking apolipoprotein A-I. J Lipid Res 46: 2007-14 PubMed GONUTS page
↑ ^13.0 ^13.1 Hyogo H et al. (2002) Leptin promotes biliary cholesterol elimination during weight loss in ob/ob mice by regulating the enterohepatic circulation of bile salts. J Biol Chem 277: 34117-24 PubMed GONUTS page
↑ Ishii M et al. (2003) Targeted disruption of GPR7, the endogenous receptor for neuropeptides B and W, leads to metabolic defects and adult-onset obesity. Proc Natl Acad Sci U S A 100: 10540-5 PubMed GONUTS page
↑ Li N et al. (1999) NMDA and AMPA glutamate receptor subtypes in the thoracic spinal cord in lean and obese-diabetic ob/ob mice. Brain Res 849: 34-44 PubMed GONUTS page
↑ Szczypka MS et al. (2000) Dopamine is required for hyperphagia in Lep(ob/ob) mice. Nat Genet 25: 102-4 PubMed GONUTS page
↑ Anand A & Chada K (2000) In vivo modulation of Hmgic reduces obesity. Nat Genet 24: 377-80 PubMed GONUTS page

[PMID:21234744-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Marroquí L et al. (2011) Leptin downregulates expression of the gene encoding glucagon in alphaTC1-9 cells and mouse islets. Diabetologia 54: 843-51 PubMed GONUTS page

[PMID:12177191-1] Hahm S et al. (2002) VGF is required for obesity induced by diet, gold thioglucose treatment, and agouti and is differentially regulated in pro-opiomelanocortin- and neuropeptide Y-containing arcuate neurons in response to fasting. J Neurosci 22: 6929-38 PubMed GONUTS page

[PMID:16141392-2] 3.0 ^3.1 ^3.2 ^3.3 Watson E et al. (2005) VGF ablation blocks the development of hyperinsulinemia and hyperglycemia in several mouse models of obesity. Endocrinology 146: 5151-63 PubMed GONUTS page

[PMID:9102398-3] Tartaglia LA (1997) The leptin receptor. J Biol Chem 272: 6093-6 PubMed GONUTS page

[PMID:9590691-4] 5.0 ^5.1 ^5.2 Kristensen P et al. (1998) Hypothalamic CART is a new anorectic peptide regulated by leptin. Nature 393: 72-6 PubMed GONUTS page

[PMID:17693256-5] Lee NK et al. (2007) Endocrine regulation of energy metabolism by the skeleton. Cell 130: 456-69 PubMed GONUTS page

[PMID:20952387-6] Peterson JM et al. (2010) C1q/TNF-related protein-3 (CTRP3), a novel adipokine that regulates hepatic glucose output. J Biol Chem 285: 39691-701 PubMed GONUTS page

[PMID:12540600-7] Maeda K et al. (2003) Role of the fatty acid binding protein mal1 in obesity and insulin resistance. Diabetes 52: 300-7 PubMed GONUTS page

[PMID:16513828-8] 9.0 ^9.1 ^9.2 ^9.3 Luque RM & Kineman RD (2006) Impact of obesity on the growth hormone axis: evidence for a direct inhibitory effect of hyperinsulinemia on pituitary function. Endocrinology 147: 2754-63 PubMed GONUTS page

[PMID:12815040-9] Miyazaki M et al. (2003) Identification and characterization of murine SCD4, a novel heart-specific stearoyl-CoA desaturase isoform regulated by leptin and dietary factors. J Biol Chem 278: 33904-11 PubMed GONUTS page

[PMID:9057630-10] 11.0 ^11.1 Mikhail AA et al. (1997) Leptin stimulates fetal and adult erythroid and myeloid development. Blood 89: 1507-12 PubMed GONUTS page

[PMID:15995171-11] Gruen ML et al. (2005) Persistence of high density lipoprotein particles in obese mice lacking apolipoprotein A-I. J Lipid Res 46: 2007-14 PubMed GONUTS page

[PMID:12114517-12] 13.0 ^13.1 Hyogo H et al. (2002) Leptin promotes biliary cholesterol elimination during weight loss in ob/ob mice by regulating the enterohepatic circulation of bile salts. J Biol Chem 277: 34117-24 PubMed GONUTS page

[PMID:12925742-13] Ishii M et al. (2003) Targeted disruption of GPR7, the endogenous receptor for neuropeptides B and W, leads to metabolic defects and adult-onset obesity. Proc Natl Acad Sci U S A 100: 10540-5 PubMed GONUTS page

[PMID:10592285-14] Li N et al. (1999) NMDA and AMPA glutamate receptor subtypes in the thoracic spinal cord in lean and obese-diabetic ob/ob mice. Brain Res 849: 34-44 PubMed GONUTS page

[PMID:10802666-15] Szczypka MS et al. (2000) Dopamine is required for hyperphagia in Lep(ob/ob) mice. Nat Genet 25: 102-4 PubMed GONUTS page

[PMID:10742101-16] Anand A & Chada K (2000) In vivo modulation of Hmgic reduces obesity. Nat Genet 24: 377-80 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Lep
Protein Name(s)	leptin,
External Links
MGI	MGI:104663

MGI:Lep

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