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MGI:Lef1
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Lef1 ( synonyms: Lef-1, lymphoid enhancer factor 1 ) | |
| Protein Name(s) | lymphoid enhancer binding factor 1, | |
| External Links | ||
| MGI | MGI:96770 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3690195 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3820325 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0001569 |
patterning of blood vessels |
MGI:MGI:3833040 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1926601 |
P |
From MGI |
||
| GO:0001649 |
osteoblast differentiation |
MGI:MGI:4459044 |
PANTHER:PTHR10373 |
P |
From MGI |
|||
| GO:0001755 |
neural crest cell migration |
MGI:MGI:4459044 |
PANTHER:PTHR10373 |
P |
From MGI |
|||
| GO:0001756 |
somitogenesis |
MGI:MGI:1334099 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:98504 |
P |
From MGI |
||
| GO:0001756 |
somitogenesis |
MGI:MGI:3510574 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1933764 |
P |
From MGI |
||
| GO:0001837 |
epithelial to mesenchymal transition |
MGI:MGI:2683382 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0001944 |
vasculature development |
MGI:MGI:3604165 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1926601 |
P |
From MGI |
||
| GO:0002040 |
sprouting angiogenesis |
MGI:MGI:3833040 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1926601 |
P |
From MGI |
||
| GO:0003677 |
DNA binding |
MGI:MGI:3510574 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:3656361 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:3690807 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003682 |
chromatin binding |
MGI:MGI:3038034 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003682 |
chromatin binding |
MGI:MGI:3690195 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003682 |
chromatin binding |
MGI:MGI:3701031 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003682 |
chromatin binding |
MGI:MGI:3784902 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
MGI:MGI:2156285 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
MGI:MGI:3510574 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
MGI:MGI:3656361 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0003705 |
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity |
MGI:MGI:3530428 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:88276 |
F |
From MGI |
||
| GO:0005515 |
protein binding |
MGI:MGI:3694173 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3784902 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:4887291 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:1344732 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:2655026 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:2681050 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:3616720 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:3784902 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_569113 |
C |
From MGI |
||
| GO:0005634 |
nucleus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4834989 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4949803 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:72097 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005667 |
transcription factor complex |
MGI:MGI:2156285 |
IPI: Inferred from Physical Interaction |
C |
From MGI |
|||
| GO:0005667 |
transcription factor complex |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:2681050 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006351 |
transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0804 |
P |
From MGI |
||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0805 |
P |
From MGI |
||
| GO:0006357 |
regulation of transcription from RNA polymerase II promoter |
MGI:MGI:2156285 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006917 |
induction of apoptosis |
MGI:MGI:3604165 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1926601 |
P |
From MGI |
||
| GO:0008013 |
beta-catenin binding |
MGI:MGI:4459044 |
PANTHER:PTHR10373 |
F |
From MGI |
|||
| GO:0008013 |
beta-catenin binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0008134 |
transcription factor binding |
MGI:MGI:2655026 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0008284 |
positive regulation of cell proliferation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0008301 |
DNA binding, bending |
MGI:MGI:3690807 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0010628 |
positive regulation of gene expression |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0010718 |
positive regulation of epithelial to mesenchymal transition |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0016055 |
Wnt receptor signaling pathway |
MGI:MGI:1306711 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0016055 |
Wnt receptor signaling pathway |
MGI:MGI:1861366 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:98956 |
P |
From MGI |
||
| GO:0016055 |
Wnt receptor signaling pathway |
MGI:MGI:3640895 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1926601 |
P |
From MGI |
||
| GO:0016055 |
Wnt receptor signaling pathway |
MGI:MGI:3722225 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1202879 |
P |
From MGI |
||
| GO:0016055 |
Wnt receptor signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0021542 |
dentate gyrus development |
MGI:MGI:1351293 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1933764 |
P |
From MGI |
||
| GO:0021766 |
hippocampus development |
MGI:MGI:1351293 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1933764 |
P |
From MGI |
||
| GO:0021854 |
hypothalamus development |
MGI:MGI:4459044 |
PANTHER:PTHR10373 |
P |
From MGI |
|||
| GO:0021861 |
forebrain radial glial cell differentiation |
MGI:MGI:2686791 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1298218 |
P |
From MGI |
||
| GO:0021873 |
forebrain neuroblast division |
MGI:MGI:2686791 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1298218 |
P |
From MGI |
||
| GO:0021879 |
forebrain neuron differentiation |
MGI:MGI:4459044 |
PANTHER:PTHR10373 |
P |
From MGI |
|||
| GO:0021943 |
formation of radial glial scaffolds |
MGI:MGI:2686791 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1298218 |
P |
From MGI |
||
| GO:0022407 |
regulation of cell-cell adhesion |
MGI:MGI:3833040 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1926601 |
P |
From MGI |
||
| GO:0022408 |
negative regulation of cell-cell adhesion |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0022409 |
positive regulation of cell-cell adhesion |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030111 |
regulation of Wnt receptor signaling pathway |
MGI:MGI:1334099 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:98504 |
P |
From MGI |
||
| GO:0030223 |
neutrophil differentiation |
MGI:MGI:4459044 |
PANTHER:PTHR10373 |
P |
From MGI |
|||
| GO:0030223 |
neutrophil differentiation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030284 |
estrogen receptor activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0030307 |
positive regulation of cell growth |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030326 |
embryonic limb morphogenesis |
MGI:MGI:1334099 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:98504 |
P |
From MGI |
||
| GO:0030331 |
estrogen receptor binding |
MGI:MGI:4459044 |
PANTHER:PTHR10373 |
F |
From MGI |
|||
| GO:0030331 |
estrogen receptor binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0030335 |
positive regulation of cell migration |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030509 |
BMP signaling pathway |
MGI:MGI:1306711 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0030520 |
intracellular estrogen receptor signaling pathway |
MGI:MGI:4459044 |
PANTHER:PTHR10373 |
P |
From MGI |
|||
| GO:0030854 |
positive regulation of granulocyte differentiation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030879 |
mammary gland development |
MGI:MGI:3640895 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1926601 |
P |
From MGI |
||
| GO:0032696 |
negative regulation of interleukin-13 production |
MGI:MGI:4459044 |
PANTHER:PTHR10373 |
P |
From MGI |
|||
| GO:0032696 |
negative regulation of interleukin-13 production |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0032713 |
negative regulation of interleukin-4 production |
MGI:MGI:4459044 |
PANTHER:PTHR10373 |
P |
From MGI |
|||
| GO:0032713 |
negative regulation of interleukin-4 production |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0032714 |
negative regulation of interleukin-5 production |
MGI:MGI:4459044 |
PANTHER:PTHR10373 |
P |
From MGI |
|||
| GO:0032714 |
negative regulation of interleukin-5 production |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0032993 |
protein-DNA complex |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0033153 |
T cell receptor V(D)J recombination |
MGI:MGI:3640275 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:98507 |
P |
From MGI |
||
| GO:0035326 |
enhancer binding |
MGI:MGI:4459044 |
PANTHER:PTHR10373 |
F |
From MGI |
|||
| GO:0035326 |
enhancer binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0042100 |
B cell proliferation |
MGI:MGI:1861366 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1926601 |
P |
From MGI |
||
| GO:0042393 |
histone binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0042475 |
odontogenesis of dentin-containing tooth |
MGI:MGI:2447924 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1926601 |
P |
From MGI |
||
| GO:0042475 |
odontogenesis of dentin-containing tooth |
MGI:MGI:3530724 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1926601 |
P |
From MGI |
||
| GO:0042475 |
odontogenesis of dentin-containing tooth |
MGI:MGI:3722225 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1202879 |
P |
From MGI |
||
| GO:0043027 |
cysteine-type endopeptidase inhibitor activity involved in apoptotic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0043066 |
negative regulation of apoptotic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043154 |
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
MGI:MGI:4459044 |
PANTHER:PTHR10373 |
P |
From MGI |
|||
| GO:0043154 |
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043392 |
negative regulation of DNA binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043401 |
steroid hormone mediated signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043565 |
sequence-specific DNA binding |
MGI:MGI:4459044 |
PANTHER:PTHR10373 |
F |
From MGI |
|||
| GO:0043565 |
sequence-specific DNA binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0043586 |
tongue development |
MGI:MGI:3703195 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1926601 |
P |
From MGI |
||
| GO:0043923 |
positive regulation by host of viral transcription |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043966 |
histone H3 acetylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043967 |
histone H4 acetylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0044212 |
transcription regulatory region DNA binding |
MGI:MGI:2655026 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0044212 |
transcription regulatory region DNA binding |
MGI:MGI:3820325 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0044212 |
transcription regulatory region DNA binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0044212 |
transcription regulatory region DNA binding |
MGI:MGI:72097 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0045063 |
T-helper 1 cell differentiation |
MGI:MGI:4834989 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045295 |
gamma-catenin binding |
MGI:MGI:4459044 |
PANTHER:PTHR10373 |
F |
From MGI |
|||
| GO:0045295 |
gamma-catenin binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0045843 |
negative regulation of striated muscle tissue development |
MGI:MGI:3656361 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045892 |
negative regulation of transcription, DNA-dependent |
MGI:MGI:2655026 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045892 |
negative regulation of transcription, DNA-dependent |
MGI:MGI:2655026 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045892 |
negative regulation of transcription, DNA-dependent |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
MGI:MGI:1351293 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
MGI:MGI:1351293 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
MGI:MGI:1861366 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1926601 |
P |
From MGI |
||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:2656434 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3039314 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1338823 |
P |
From MGI |
||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3510574 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3703195 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1926601 |
P |
From MGI |
||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0046632 |
alpha-beta T cell differentiation |
MGI:MGI:3640275 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:98507 |
P |
From MGI |
||
| GO:0048069 |
eye pigmentation |
MGI:MGI:4459044 |
PANTHER:PTHR10373 |
P |
From MGI |
|||
| GO:0048341 |
paraxial mesoderm formation |
MGI:MGI:1334099 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:98504 |
P |
From MGI |
||
| GO:0048468 |
cell development |
MGI:MGI:3530428 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:104554 |
P |
From MGI |
||
| GO:0048747 |
muscle fiber development |
MGI:MGI:4459044 |
PANTHER:PTHR10373 |
P |
From MGI |
|||
| GO:0050909 |
sensory perception of taste |
MGI:MGI:3703195 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1926601 |
P |
From MGI |
||
| GO:0060021 |
palate development |
MGI:MGI:2683382 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0060033 |
anatomical structure regression |
MGI:MGI:3604165 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1926601 |
P |
From MGI |
||
| GO:0060070 |
canonical Wnt receptor signaling pathway |
MGI:MGI:4459044 |
PANTHER:PTHR10373 |
P |
From MGI |
|||
| GO:0060070 |
canonical Wnt receptor signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0060325 |
face morphogenesis |
MGI:MGI:3722225 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1202879 |
P |
From MGI |
||
| GO:0060326 |
cell chemotaxis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0060561 |
apoptotic process involved in morphogenesis |
MGI:MGI:3530724 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1926601 |
P |
From MGI |
||
| GO:0060710 |
chorio-allantoic fusion |
MGI:MGI:1334099 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:98504 |
P |
From MGI |
||
| GO:0061153 |
trachea gland development |
MGI:MGI:1345559 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1926601 |
P |
From MGI |
||
| GO:0070016 |
armadillo repeat domain binding |
MGI:MGI:4459044 |
PANTHER:PTHR10373 |
F |
From MGI |
|||
| GO:0070016 |
armadillo repeat domain binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0070742 |
C2H2 zinc finger domain binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0071353 |
cellular response to interleukin-4 |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0071864 |
positive regulation of cell proliferation in bone marrow |
MGI:MGI:4459044 |
PANTHER:PTHR10373 |
P |
From MGI |
|||
| GO:0071864 |
positive regulation of cell proliferation in bone marrow |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0071866 |
negative regulation of apoptotic process in bone marrow |
MGI:MGI:4459044 |
PANTHER:PTHR10373 |
P |
From MGI |
|||
| GO:0071866 |
negative regulation of apoptotic process in bone marrow |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0071895 |
odontoblast differentiation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_569113 |
P |
From MGI |
||
| GO:0071895 |
odontoblast differentiation |
MGI:MGI:4459044 |
PANTHER:PTHR10373 |
P |
From MGI |
|||
| GO:0071899 |
negative regulation of estrogen receptor binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0090068 |
positive regulation of cell cycle process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0090090 |
negative regulation of canonical Wnt receptor signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Olson LE et al. (2006) Homeodomain-mediated beta-catenin-dependent switching events dictate cell-lineage determination. Cell 125: 593-605 PubMed GONUTS page
- ↑ 2.0 2.1 Miranda-Carboni GA et al. (2008) A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors. Genes Dev 22: 3121-34 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Phng LK et al. (2009) Nrarp coordinates endothelial Notch and Wnt signaling to control vessel density in angiogenesis. Dev Cell 16: 70-82 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 Galceran J et al. (1999) Wnt3a-/--like phenotype and limb deficiency in Lef1(-/-)Tcf1(-/-) mice. Genes Dev 13: 709-17 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 Galceran J et al. (2004) LEF1-mediated regulation of Delta-like1 links Wnt and Notch signaling in somitogenesis. Genes Dev 18: 2718-23 PubMed GONUTS page
- ↑ 6.0 6.1 Nawshad A & Hay ED (2003) TGFbeta3 signaling activates transcription of the LEF1 gene to induce epithelial mesenchymal transformation during mouse palate development. J Cell Biol 163: 1291-301 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 Lobov IB et al. (2005) WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature. Nature 437: 417-21 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 Borello U et al. (2006) The Wnt/beta-catenin pathway regulates Gli-mediated Myf5 expression during somitogenesis. Development 133: 3723-32 PubMed GONUTS page
- ↑ 9.0 9.1 Giese K et al. (1995) Assembly and function of a TCR alpha enhancer complex is dependent on LEF-1-induced DNA bending and multiple protein-protein interactions. Genes Dev 9: 995-1008 PubMed GONUTS page
- ↑ Goodall J et al. (2004) Brn-2 expression controls melanoma proliferation and is directly regulated by beta-catenin. Mol Cell Biol 24: 2915-22 PubMed GONUTS page
- ↑ Später D et al. (2006) Wnt9a signaling is required for joint integrity and regulation of Ihh during chondrogenesis. Development 133: 3039-49 PubMed GONUTS page
- ↑ 12.0 12.1 12.2 Ray S et al. (2008) Cooperative control via lymphoid enhancer factor 1/T cell factor 3 and estrogen receptor-alpha for uterine gene regulation by estrogen. Mol Endocrinol 22: 1125-40 PubMed GONUTS page
- ↑ 13.0 13.1 13.2 Boras K & Hamel PA (2002) Alx4 binding to LEF-1 regulates N-CAM promoter activity. J Biol Chem 277: 1120-7 PubMed GONUTS page
- ↑ 14.0 14.1 Lang D et al. (2005) Pax3 functions at a nodal point in melanocyte stem cell differentiation. Nature 433: 884-7 PubMed GONUTS page
- ↑ Choi HJ et al. (2006) Thermodynamics of beta-catenin-ligand interactions: the roles of the N- and C-terminal tails in modulating binding affinity. J Biol Chem 281: 1027-38 PubMed GONUTS page
- ↑ Liu X et al. (2010) Sox17 modulates Wnt3A/beta-catenin-mediated transcriptional activation of the Lef-1 promoter. Am J Physiol Lung Cell Mol Physiol 299: L694-710 PubMed GONUTS page
- ↑ DasGupta R & Fuchs E (1999) Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation. Development 126: 4557-68 PubMed GONUTS page
- ↑ 18.0 18.1 18.2 18.3 18.4 Kahler RA & Westendorf JJ (2003) Lymphoid enhancer factor-1 and beta-catenin inhibit Runx2-dependent transcriptional activation of the osteocalcin promoter. J Biol Chem 278: 11937-44 PubMed GONUTS page
- ↑ 19.0 19.1 Michno K et al. (2003) Shh expression is required for embryonic hair follicle but not mammary gland development. Dev Biol 264: 153-65 PubMed GONUTS page
- ↑ Wu X et al. (2006) Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin. Genes Dev 20: 571-85 PubMed GONUTS page
- ↑ 21.0 21.1 Hebenstreit D et al. (2008) LEF-1 negatively controls interleukin-4 expression through a proximal promoter regulatory element. J Biol Chem 283: 22490-7 PubMed GONUTS page
- ↑ Osorio KM et al. (2011) Runx1 modulates adult hair follicle stem cell emergence and maintenance from distinct embryonic skin compartments. J Cell Biol 193: 235-50 PubMed GONUTS page
- ↑ 23.0 23.1 Zhou P et al. (1995) Lymphoid enhancer factor 1 directs hair follicle patterning and epithelial cell fate. Genes Dev 9: 700-13 PubMed GONUTS page
- ↑ 24.0 24.1 Dassule HR & McMahon AP (1998) Analysis of epithelial-mesenchymal interactions in the initial morphogenesis of the mammalian tooth. Dev Biol 202: 215-27 PubMed GONUTS page
- ↑ 25.0 25.1 25.2 Reya T et al. (2000) Wnt signaling regulates B lymphocyte proliferation through a LEF-1 dependent mechanism. Immunity 13: 15-24 PubMed GONUTS page
- ↑ 26.0 26.1 Boras-Granic K et al. (2006) Lef1 is required for the transition of Wnt signaling from mesenchymal to epithelial cells in the mouse embryonic mammary gland. Dev Biol 295: 219-31 PubMed GONUTS page
- ↑ 27.0 27.1 27.2 Brugmann SA et al. (2007) Wnt signaling mediates regional specification in the vertebrate face. Development 134: 3283-95 PubMed GONUTS page
- ↑ 28.0 28.1 28.2 28.3 Galceran J et al. (2000) Hippocampus development and generation of dentate gyrus granule cells is regulated by LEF1. Development 127: 469-82 PubMed GONUTS page
- ↑ 29.0 29.1 29.2 Zhou CJ et al. (2004) Wnt signaling mutants have decreased dentate granule cell production and radial glial scaffolding abnormalities. J Neurosci 24: 121-6 PubMed GONUTS page
- ↑ 30.0 30.1 Okamura RM et al. (1998) Redundant regulation of T cell differentiation and TCRalpha gene expression by the transcription factors LEF-1 and TCF-1. Immunity 8: 11-20 PubMed GONUTS page
- ↑ Kratochwil K et al. (2002) FGF4, a direct target of LEF1 and Wnt signaling, can rescue the arrest of tooth organogenesis in Lef1(-/-) mice. Genes Dev 16: 3173-85 PubMed GONUTS page
- ↑ 32.0 32.1 Sasaki T et al. (2005) LEF1 is a critical epithelial survival factor during tooth morphogenesis. Dev Biol 278: 130-43 PubMed GONUTS page
- ↑ 33.0 33.1 33.2 Iwatsuki K et al. (2007) Wnt signaling interacts with Shh to regulate taste papilla development. Proc Natl Acad Sci U S A 104: 2253-8 PubMed GONUTS page
- ↑ Surendran K & Simon TC (2003) CNP gene expression is activated by Wnt signaling and correlates with Wnt4 expression during renal injury. Am J Physiol Renal Physiol 284: F653-62 PubMed GONUTS page
- ↑ Wu CX et al. (2004) Activation of mouse RAG-2 promoter by Myc-associated zinc finger protein. Biochem Biophys Res Commun 317: 1096-102 PubMed GONUTS page
- ↑ Duan D et al. (1999) Submucosal gland development in the airway is controlled by lymphoid enhancer binding factor 1 (LEF1). Development 126: 4441-53 PubMed GONUTS page
