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MGI:Ldlr
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Ldlr | |
| Protein Name(s) | low density lipoprotein receptor, | |
| External Links | ||
| MGI | MGI:96765 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001948 |
glycoprotein binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0004872 |
receptor activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0675 |
F |
From MGI |
||
| GO:0005041 |
low-density lipoprotein receptor activity |
MGI:MGI:2386141 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005041 |
low-density lipoprotein receptor activity |
MGI:MGI:3706212 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857212 |
F |
From MGI |
||
| GO:0005041 |
low-density lipoprotein receptor activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005041 |
low-density lipoprotein receptor activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005509 |
calcium ion binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:2385379 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005764 |
lysosome |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005768 |
endosome |
MGI:MGI:2669061 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005769 |
early endosome |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005901 |
caveola |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005905 |
coated pit |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006629 |
lipid metabolic process |
MGI:MGI:1928445 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:88052 |
P |
From MGI |
||
| GO:0006810 |
transport |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0813 |
P |
From MGI |
||
| GO:0006869 |
lipid transport |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0445 |
P |
From MGI |
||
| GO:0006897 |
endocytosis |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006898 |
receptor-mediated endocytosis |
MGI:MGI:2386141 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006898 |
receptor-mediated endocytosis |
MGI:MGI:3695062 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0008202 |
steroid metabolic process |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0753 |
P |
From MGI |
||
| GO:0008203 |
cholesterol metabolic process |
MGI:MGI:3696597 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857212 |
P |
From MGI |
||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0010867 |
positive regulation of triglyceride biosynthetic process |
MGI:MGI:3784112 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0010899 |
regulation of phosphatidylcholine catabolic process |
MGI:MGI:3784112 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0015914 |
phospholipid transport |
MGI:MGI:3784112 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016021 |
integral to membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0812 |
C |
From MGI |
||
| GO:0030169 |
low-density lipoprotein particle binding |
MGI:MGI:3583861 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0030169 |
low-density lipoprotein particle binding |
MGI:MGI:70746 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0030229 |
very-low-density lipoprotein particle receptor activity |
MGI:MGI:3695062 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0030229 |
very-low-density lipoprotein particle receptor activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0030299 |
intestinal cholesterol absorption |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030301 |
cholesterol transport |
MGI:MGI:3706212 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857212 |
P |
From MGI |
||
| GO:0030301 |
cholesterol transport |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0034362 |
low-density lipoprotein particle |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0427 |
C |
From MGI |
||
| GO:0034383 |
low-density lipoprotein particle clearance |
MGI:MGI:3784112 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0034383 |
low-density lipoprotein particle clearance |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042157 |
lipoprotein metabolic process |
MGI:MGI:1928445 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:88052 |
P |
From MGI |
||
| GO:0042157 |
lipoprotein metabolic process |
MGI:MGI:3028770 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:88052 |
P |
From MGI |
||
| GO:0042159 |
lipoprotein catabolic process |
MGI:MGI:1313233 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857212 |
P |
From MGI |
||
| GO:0042159 |
lipoprotein catabolic process |
MGI:MGI:3576461 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857212 |
P |
From MGI |
||
| GO:0042159 |
lipoprotein catabolic process |
MGI:MGI:3583861 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0042632 |
cholesterol homeostasis |
MGI:MGI:1313233 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857212 |
P |
From MGI |
||
| GO:0042632 |
cholesterol homeostasis |
MGI:MGI:1928445 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:88052 |
P |
From MGI |
||
| GO:0042632 |
cholesterol homeostasis |
MGI:MGI:2669061 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857212 |
P |
From MGI |
||
| GO:0042632 |
cholesterol homeostasis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0055038 |
recycling endosome membrane |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0070508 |
cholesterol import |
MGI:MGI:3784112 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Kulinski A et al. (2002) Microsomal triacylglycerol transfer protein is required for lumenal accretion of triacylglycerol not associated with ApoB, as well as for ApoB lipidation. J Biol Chem 277: 31516-25 PubMed GONUTS page
- ↑ 2.0 2.1 Wang MD et al. (2007) Different cellular traffic of LDL-cholesterol and acetylated LDL-cholesterol leads to distinct reverse cholesterol transport pathways. J Lipid Res 48: 633-45 PubMed GONUTS page
- ↑ Stockinger W et al. (2002) The PX-domain protein SNX17 interacts with members of the LDL receptor family and modulates endocytosis of the LDL receptor. EMBO J 21: 4259-67 PubMed GONUTS page
- ↑ 4.0 4.1 Jones C et al. (2003) Normal sorting but defective endocytosis of the low density lipoprotein receptor in mice with autosomal recessive hypercholesterolemia. J Biol Chem 278: 29024-30 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Véniant MM et al. (2000) Defining the atherogenicity of large and small lipoproteins containing apolipoprotein B100. J Clin Invest 106: 1501-10 PubMed GONUTS page
- ↑ 6.0 6.1 Grosskopf I et al. (2005) Apolipoprotein A-V deficiency results in marked hypertriglyceridemia attributable to decreased lipolysis of triglyceride-rich lipoproteins and removal of their remnants. Arterioscler Thromb Vasc Biol 25: 2573-9 PubMed GONUTS page
- ↑ Zabalawi M et al. (2007) Inflammation and skin cholesterol in LDLr-/-, apoA-I-/- mice: link between cholesterol homeostasis and self-tolerance? J Lipid Res 48: 52-65 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 8.3 8.4 Minahk C et al. (2008) Conversion of low density lipoprotein-associated phosphatidylcholine to triacylglycerol by primary hepatocytes. J Biol Chem 283: 6449-58 PubMed GONUTS page
- ↑ 9.0 9.1 Lalanne F et al. (2005) Wild-type PCSK9 inhibits LDL clearance but does not affect apoB-containing lipoprotein production in mouse and cultured cells. J Lipid Res 46: 1312-9 PubMed GONUTS page
- ↑ van Ree JH et al. (1995) Increased response to cholesterol feeding in apolipoprotein C1-deficient mice. Biochem J 305 ( Pt 3): 905-11 PubMed GONUTS page
- ↑ Chen Z et al. (2004) Hepatic secretion of apoB-100 is impaired in hypobetalipoproteinemic mice with an apoB-38.9-specifying allele. J Lipid Res 45: 155-63 PubMed GONUTS page
- ↑ 12.0 12.1 Véniant MM et al. (1998) Lipoprotein clearance mechanisms in LDL receptor-deficient "Apo-B48-only" and "Apo-B100-only" mice. J Clin Invest 102: 1559-68 PubMed GONUTS page
- ↑ Rashid S et al. (2005) Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9. Proc Natl Acad Sci U S A 102: 5374-9 PubMed GONUTS page
