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MGI:Ldha

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Contents

Species (Taxon ID) Mus musculus (house mouse) (taxon:10090)
Gene Name(s) Ldha ( synonyms: l7R2, lactate dehydrogenase-A, Ldh-1, LDH-A, Ldh1 )
Protein Name(s) lactate dehydrogenase A,
External Links
MGI MGI:96759

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000166

nucleotide binding

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR016040

F

From MGI

GO:0003824

catalytic activity

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR015955

F

From MGI

GO:0004457

lactate dehydrogenase activity

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P04642

F

From MGI

GO:0004459

L-lactate dehydrogenase activity

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P04642

F

From MGI

GO:0004459

L-lactate dehydrogenase activity

MGI:MGI:55148
PMID:7323947[1]

IDA: Inferred from Direct Assay

F

From MGI

GO:0004459

L-lactate dehydrogenase activity

MGI:MGI:63598
PMID:3796661[2]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3776263

F

From MGI

GO:0005515

protein binding

MGI:MGI:3693398
PMID:12107167[3]

IPI: Inferred from Physical Interaction

UniProtKB:Q60668

F

From MGI

GO:0005625

soluble fraction

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P04642

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0963

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR011304

C

From MGI

GO:0005739

mitochondrion

MGI:MGI:3852644
PMID:18614015[4]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005829

cytosol

MGI:MGI:2178871
PMID:11980919[5]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005975

carbohydrate metabolic process

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR015955

P

From MGI

GO:0006089

lactate metabolic process

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P04642

P

From MGI

GO:0006096

glycolysis

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0324

P

From MGI

GO:0006096

glycolysis

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR011304

P

From MGI

GO:0016491

oxidoreductase activity

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0560

F

From MGI

GO:0016491

oxidoreductase activity

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR001236

F

From MGI

GO:0016616

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR001557
InterPro:IPR022383
InterPro:IPR015955

F

From MGI

GO:0019674

NAD metabolic process

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P04642

P

From MGI

GO:0019861

flagellum

MGI:MGI:3654822
PMID:16687649[6]

IDA: Inferred from Direct Assay

C

From MGI

GO:0019900

kinase binding

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P04642

F

From MGI

GO:0031668

cellular response to extracellular stimulus

MGI:MGI:1335904
PMID:10322635[7]

IDA: Inferred from Direct Assay

P

From MGI

GO:0042802

identical protein binding

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P04642

F

From MGI

GO:0043065

positive regulation of apoptotic process

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P04642

P

From MGI

GO:0044262

cellular carbohydrate metabolic process

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR001557

P

From MGI

GO:0051287

NAD binding

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P04642

F

From MGI


Notes

References

See Help:References for how to manage references in GONUTS.
  1. Stallings RL & Siciliano MJ (1981) Confirmational, provisional, and/or regional assignment of 15 enzyme loci onto Chinese hamster autosomes 1, 2, and 7. Somatic Cell Genet 7: 683-98 PubMed GONUTS page
  2. Charles DJ & Pretsch W (1987) Linear dose-response relationship of erythrocyte enzyme-activity mutations in offspring of ethylnitrosourea-treated mice. Mutat Res 176: 81-91 PubMed GONUTS page
  3. Pioli PA et al. (2002) Lactate dehydrogenase is an AU-rich element-binding protein that directly interacts with AUF1. J Biol Chem 277: 35738-45 PubMed GONUTS page
  4. Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134: 112-23 PubMed GONUTS page
  5. Putcha GV et al. (2002) Intrinsic and extrinsic pathway signaling during neuronal apoptosis: lessons from the analysis of mutant mice. J Cell Biol 157: 441-53 PubMed GONUTS page
  6. Krisfalusi M et al. (2006) Multiple glycolytic enzymes are tightly bound to the fibrous sheath of mouse spermatozoa. Biol Reprod 75: 270-8 PubMed GONUTS page
  7. Leimeister C et al. (1999) Screen for genes regulated during early kidney morphogenesis. Dev Genet 24: 273-83 PubMed GONUTS page
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