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MGI:Lck
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Lck ( synonyms: Hck-3, p56 ) | |
| Protein Name(s) | lymphocyte protein tyrosine kinase, | |
| External Links | ||
| MGI | MGI:96756 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000166 |
nucleotide binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0547 |
F |
From MGI |
||
| GO:0000242 |
pericentriolar material |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0001948 |
glycoprotein binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0003823 |
antigen binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0004672 |
protein kinase activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0004713 |
protein tyrosine kinase activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0004713 |
protein tyrosine kinase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0004713 |
protein tyrosine kinase activity |
MGI:MGI:65996 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004713 |
protein tyrosine kinase activity |
MGI:MGI:77358 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004713 |
protein tyrosine kinase activity |
MGI:MGI:892668 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004715 |
non-membrane spanning protein tyrosine kinase activity |
MGI:MGI:2152096 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0004722 |
protein serine/threonine phosphatase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:1347688 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3588813 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3694161 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:4441130 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:4441153 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:4839452 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:5142398 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005524 |
ATP binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0067 |
F |
From MGI |
||
| GO:0005524 |
ATP binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0963 |
C |
From MGI |
||
| GO:0005794 |
Golgi apparatus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006468 |
protein phosphorylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006468 |
protein phosphorylation |
MGI:MGI:892668 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006917 |
induction of apoptosis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006919 |
activation of cysteine-type endopeptidase activity involved in apoptotic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007166 |
cell surface receptor signaling pathway |
MGI:MGI:87805 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0008022 |
protein C-terminus binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0009612 |
response to mechanical stimulus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0010038 |
response to metal ion |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0010628 |
positive regulation of gene expression |
MGI:MGI:4947150 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016301 |
kinase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0418 |
F |
From MGI |
||
| GO:0016310 |
phosphorylation |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0418 |
P |
From MGI |
||
| GO:0016311 |
dephosphorylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0016740 |
transferase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0808 |
F |
From MGI |
||
| GO:0016772 |
transferase activity, transferring phosphorus-containing groups |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0018108 |
peptidyl-tyrosine phosphorylation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0018108 |
peptidyl-tyrosine phosphorylation |
MGI:MGI:65996 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0018108 |
peptidyl-tyrosine phosphorylation |
MGI:MGI:77358 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0019901 |
protein kinase binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0030139 |
endocytic vesicle |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0030217 |
T cell differentiation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0032403 |
protein complex binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0042169 |
SH2 domain binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0042493 |
response to drug |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042523 |
positive regulation of tyrosine phosphorylation of Stat5 protein |
MGI:MGI:1933047 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0042542 |
response to hydrogen peroxide |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042609 |
CD4 receptor binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0042610 |
CD8 receptor binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0043548 |
phosphatidylinositol 3-kinase binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0045121 |
membrane raft |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0045121 |
membrane raft |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0045588 |
positive regulation of gamma-delta T cell differentiation |
MGI:MGI:70338 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857211 |
P |
From MGI |
||
| GO:0046777 |
protein autophosphorylation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0046777 |
protein autophosphorylation |
MGI:MGI:65996 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0050853 |
B cell receptor signaling pathway |
MGI:MGI:77358 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0050856 |
regulation of T cell receptor signaling pathway |
MGI:MGI:3042327 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0050870 |
positive regulation of T cell activation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0051117 |
ATPase binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0051209 |
release of sequestered calcium ion into cytosol |
MGI:MGI:3687439 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0070474 |
positive regulation of uterine smooth muscle contraction |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Burns CM et al. (1994) CD45 regulation of tyrosine phosphorylation and enzyme activity of src family kinases. J Biol Chem 269: 13594-600 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Katagiri T et al. (1995) Selective regulation of Lyn tyrosine kinase by CD45 in immature B cells. J Biol Chem 270: 27987-90 PubMed GONUTS page
- ↑ 3.0 3.1 Takaki S et al. (1997) Characterization of Lnk. An adaptor protein expressed in lymphocytes. J Biol Chem 272: 14562-70 PubMed GONUTS page
- ↑ Choi YB et al. (1999) Lad, an adapter protein interacting with the SH2 domain of p56lck, is required for T cell activation. J Immunol 163: 5242-9 PubMed GONUTS page
- ↑ Tran DD et al. (2005) CAML is a p56Lck-interacting protein that is required for thymocyte development. Immunity 23: 139-52 PubMed GONUTS page
- ↑ Ingley E et al. (2000) HS1 interacts with Lyn and is critical for erythropoietin-induced differentiation of erythroid cells. J Biol Chem 275: 7887-93 PubMed GONUTS page
- ↑ Macdonald A et al. (2004) The hepatitis C virus NS5A protein binds to members of the Src family of tyrosine kinases and regulates kinase activity. J Gen Virol 85: 721-9 PubMed GONUTS page
- ↑ Fusaki N et al. (1997) Interaction between Sam68 and Src family tyrosine kinases, Fyn and Lck, in T cell receptor signaling. J Biol Chem 272: 6214-9 PubMed GONUTS page
- ↑ Macdonald A et al. (2005) Further studies on hepatitis C virus NS5A-SH3 domain interactions: identification of residues critical for binding and implications for viral RNA replication and modulation of cell signalling. J Gen Virol 86: 1035-44 PubMed GONUTS page
- ↑ Ng DH et al. (1996) Demonstration of a direct interaction between p56lck and the cytoplasmic domain of CD45 in vitro. J Biol Chem 271: 1295-300 PubMed GONUTS page
- ↑ Sammar M et al. (1997) Mouse CD24 as a signaling molecule for integrin-mediated cell binding: functional and physical association with src-kinases. Biochem Biophys Res Commun 234: 330-4 PubMed GONUTS page
- ↑ Gimferrer I et al. (2011) Regulation of GATA-3 expression during CD4 lineage differentiation. J Immunol 186: 3892-8 PubMed GONUTS page
- ↑ Ilan N et al. (2001) Pecam-1 is a modulator of stat family member phosphorylation and localization: lessons from a transgenic mouse. Dev Biol 232: 219-32 PubMed GONUTS page
- ↑ Kawai K et al. (1995) Impaired development of V gamma 3 dendritic epidermal T cells in p56lck protein tyrosine kinase-deficient and CD45 protein tyrosine phosphatase-deficient mice. J Exp Med 181: 345-9 PubMed GONUTS page
- ↑ Hasegawa K et al. (2004) PEST domain-enriched tyrosine phosphatase (PEP) regulation of effector/memory T cells. Science 303: 685-9 PubMed GONUTS page
- ↑ Straus DB & Weiss A (1992) Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor. Cell 70: 585-93 PubMed GONUTS page
