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MGI:Lats2
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Lats2 | |
| Protein Name(s) | large tumor suppressor 2, | |
| External Links | ||
| MGI | MGI:1354386 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000082 |
G1/S transition of mitotic cell cycle |
MGI:MGI:3056218 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0000082 |
G1/S transition of mitotic cell cycle |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0000166 |
nucleotide binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0547 |
F |
From MGI |
||
| GO:0000922 |
spindle pole |
MGI:MGI:3056218 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0000922 |
spindle pole |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0004672 |
protein kinase activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0004674 |
protein serine/threonine kinase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005524 |
ATP binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:3785211 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:103262 |
C |
From MGI |
||
| GO:0005634 |
nucleus |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0963 |
C |
From MGI |
||
| GO:0005856 |
cytoskeleton |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0206 |
C |
From MGI |
||
| GO:0006468 |
protein phosphorylation |
MGI:MGI:3839170 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006468 |
protein phosphorylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007049 |
cell cycle |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0131 |
P |
From MGI |
||
| GO:0007067 |
mitosis |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0498 |
P |
From MGI |
||
| GO:0007243 |
intracellular protein kinase cascade |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0009755 |
hormone-mediated signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0016301 |
kinase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0418 |
F |
From MGI |
||
| GO:0016310 |
phosphorylation |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0418 |
P |
From MGI |
||
| GO:0016740 |
transferase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0808 |
F |
From MGI |
||
| GO:0016772 |
transferase activity, transferring phosphorus-containing groups |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0030216 |
keratinocyte differentiation |
MGI:MGI:3785211 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:103262 |
P |
From MGI |
||
| GO:0034613 |
cellular protein localization |
MGI:MGI:3839170 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0034613 |
cellular protein localization |
MGI:MGI:3839170 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1333883 |
P |
From MGI |
||
| GO:0035329 |
hippo signaling cascade |
MGI:MGI:3785211 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:103262 |
P |
From MGI |
||
| GO:0035329 |
hippo signaling cascade |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045736 |
negative regulation of cyclin-dependent protein kinase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0046620 |
regulation of organ growth |
MGI:MGI:4948149 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:4430538 |
P |
From MGI |
||
| GO:0046872 |
metal ion binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0479 |
F |
From MGI |
||
| GO:0051301 |
cell division |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0132 |
P |
From MGI |
||
| GO:0090090 |
negative regulation of canonical Wnt receptor signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0090090 |
negative regulation of canonical Wnt receptor signaling pathway |
MGI:MGI:4948149 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:88276 |
P |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 McPherson JP et al. (2004) Lats2/Kpm is required for embryonic development, proliferation control and genomic integrity. EMBO J 23: 3677-88 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Lee JH et al. (2008) A crucial role of WW45 in developing epithelial tissues in the mouse. EMBO J 27: 1231-42 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Nishioka N et al. (2009) The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass. Dev Cell 16: 398-410 PubMed GONUTS page
- ↑ 4.0 4.1 Heallen T et al. (2011) Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size. Science 332: 458-61 PubMed GONUTS page
