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MGI:Lamp1

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Contents

Species (Taxon ID) Mus musculus (house mouse) (taxon:10090)
Gene Name(s) Lamp1 ( synonyms: CD107a, Lamp-1 )
Protein Name(s) lysosomal-associated membrane protein 1,
External Links
MGI MGI:96745

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005515

protein binding

MGI:MGI:3828400
PMID:16674683[1]

IPI: Inferred from Physical Interaction

UniProtKB:P63277

F

From MGI

GO:0005764

lysosome

MGI:MGI:2154458

ISO: Inferred from Sequence Orthology

UniProtKB:P11279

C

From MGI

GO:0005764

lysosome

MGI:MGI:2182212
PMID:11486041[2]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005764

lysosome

MGI:MGI:2673073
PMID:12925704[3]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005764

lysosome

MGI:MGI:2687086
PMID:14643301[4]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005764

lysosome

MGI:MGI:3033879
PMID:11854359[5]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005764

lysosome

MGI:MGI:3037131
PMID:15006695[6]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005764

lysosome

MGI:MGI:3051925
PMID:15292400[7]

ISO: Inferred from Sequence Orthology

UniProtKB:P11279

C

From MGI

GO:0005764

lysosome

MGI:MGI:3054306
PMID:15294975[8]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005764

lysosome

MGI:MGI:3527911
PMID:15588329[9]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005764

lysosome

MGI:MGI:3615690
PMID:16415873[10]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005764

lysosome

MGI:MGI:3654230
PMID:16542649[11]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005764

lysosome

MGI:MGI:3706740
PMID:10787428[12]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005764

lysosome

MGI:MGI:3790551
PMID:18477453[13]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005768

endosome

MGI:MGI:3706740
PMID:10787428[12]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005770

late endosome

MGI:MGI:2154458

ISO: Inferred from Sequence Orthology

UniProtKB:P11279

C

From MGI

GO:0005770

late endosome

MGI:MGI:2449836
PMID:12446704[14]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005770

late endosome

MGI:MGI:3042340
PMID:14668490[15]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005770

late endosome

MGI:MGI:3051925
PMID:15292400[7]

ISO: Inferred from Sequence Orthology

UniProtKB:P11279

C

From MGI

GO:0005770

late endosome

MGI:MGI:3054306
PMID:15294975[8]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005770

late endosome

MGI:MGI:3615690
PMID:16415873[10]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005770

late endosome

MGI:MGI:3758128
PMID:17620357[16]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005770

late endosome

MGI:MGI:3790551
PMID:18477453[13]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005771

multivesicular body

MGI:MGI:3033879
PMID:11854359[5]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005771

multivesicular body

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P14562

C

From MGI

GO:0005886

plasma membrane

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-1003

C

From MGI

GO:0007283

spermatogenesis

MGI:MGI:3808932
PMID:18689890[17]

TAS: Traceable Author Statement

P

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:3686949
PMID:16973387[18]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009986

cell surface

MGI:MGI:3828400
PMID:16674683[1]

IDA: Inferred from Direct Assay

C

From MGI

GO:0016020

membrane

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

From MGI

GO:0016020

membrane

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR002000

C

From MGI

GO:0016021

integral to membrane

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0812

C

From MGI

GO:0030425

dendrite

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P14562

C

From MGI

GO:0031410

cytoplasmic vesicle

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P14562

C

From MGI

GO:0031982

vesicle

MGI:MGI:3706740
PMID:10787428[12]

IDA: Inferred from Direct Assay

C

From MGI

GO:0042383

sarcolemma

MGI:MGI:2683818
PMID:14506282[19]

IDA: Inferred from Direct Assay

C

From MGI

GO:0042470

melanosome

MGI:MGI:1930900
PMID:11266470[20]

IDA: Inferred from Direct Assay

C

From MGI

GO:0043025

neuronal cell body

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P14562

C

From MGI

GO:0048102

autophagic cell death

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P14562

P

From MGI

GO:0097208

alveolar lamellar body

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P14562

C

From MGI


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 Deutsch D et al. (2006) Amelogenin, a major structural protein in mineralizing enamel, is also expressed in soft tissues: brain and cells of the hematopoietic system. Eur J Oral Sci 114 Suppl 1: 183-9; discussion 201-2, 381 PubMed GONUTS page
  2. Plitz T & Pfeffer K (2001) Intact lysosome transport and phagosome function despite kinectin deficiency. Mol Cell Biol 21: 6044-55 PubMed GONUTS page
  3. Chakrabarti S et al. (2003) Impaired membrane resealing and autoimmune myositis in synaptotagmin VII-deficient mice. J Cell Biol 162: 543-9 PubMed GONUTS page
  4. Yada A et al. (2003) Accelerated antigen presentation and elicitation of humoral response in vivo by FcgammaRIIB- and FcgammaRI/III-mediated immune complex uptake. Cell Immunol 225: 21-32 PubMed GONUTS page
  5. 5.0 5.1 Lankar D et al. (2002) Dynamics of major histocompatibility complex class II compartments during B cell receptor-mediated cell activation. J Exp Med 195: 461-72 PubMed GONUTS page
  6. Aula N et al. (2004) Sialin expression in the CNS implicates extralysosomal function in neurons. Neurobiol Dis 15: 251-61 PubMed GONUTS page
  7. 7.0 7.1 Simonsen A et al. (2004) Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranes. J Cell Sci 117: 4239-51 PubMed GONUTS page
  8. 8.0 8.1 Sevilla LM et al. (2004) Endoplasmic reticulum-associated degradation-induced dissociation of class II invariant chain complexes containing a glycosylation-deficient form of p41. J Immunol 173: 2586-93 PubMed GONUTS page
  9. Fossale E et al. (2004) Membrane trafficking and mitochondrial abnormalities precede subunit c deposition in a cerebellar cell model of juvenile neuronal ceroid lipofuscinosis. BMC Neurosci 5: 57 PubMed GONUTS page
  10. 10.0 10.1 Tabeta K et al. (2006) The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9. Nat Immunol 7: 156-64 PubMed GONUTS page
  11. Ahtiainen L et al. (2006) Palmitoyl protein thioesterase 1 (PPT1) deficiency causes endocytic defects connected to abnormal saposin processing. Exp Cell Res 312: 1540-53 PubMed GONUTS page
  12. 12.0 12.1 12.2 Garver WS et al. (2000) Localization of the murine Niemann-Pick C1 protein to two distinct intracellular compartments. J Lipid Res 41: 673-87 PubMed GONUTS page
  13. 13.0 13.1 Capurro MI et al. (2008) Glypican-3 inhibits Hedgehog signaling during development by competing with patched for Hedgehog binding. Dev Cell 14: 700-11 PubMed GONUTS page
  14. Sun P et al. (2003) Small GTPase Rah/Rab34 is associated with membrane ruffles and macropinosomes and promotes macropinosome formation. J Biol Chem 278: 4063-71 PubMed GONUTS page
  15. Richardson SC et al. (2004) Mammalian late vacuole protein sorting orthologues participate in early endosomal fusion and interact with the cytoskeleton. Mol Biol Cell 15: 1197-210 PubMed GONUTS page
  16. Stober CB et al. (2007) Slc11a1, formerly Nramp1, is expressed in dendritic cells and influences major histocompatibility complex class II expression and antigen-presenting cell function. Infect Immun 75: 5059-67 PubMed GONUTS page
  17. Turner LM et al. (2008) Comparative analysis of testis protein evolution in rodents. Genetics 179: 2075-89 PubMed GONUTS page
  18. Marie JC et al. (2006) Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor. Immunity 25: 441-54 PubMed GONUTS page
  19. Lennon NJ et al. (2003) Dysferlin interacts with annexins A1 and A2 and mediates sarcolemmal wound-healing. J Biol Chem 278: 50466-73 PubMed GONUTS page
  20. Hume AN et al. (2001) Rab27a regulates the peripheral distribution of melanosomes in melanocytes. J Cell Biol 152: 795-808 PubMed GONUTS page
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