GONUTS is under stress! The website is currently experiencing long-wait times and frequent time-outs due to the record number of students, groups, and annotations related to CACAO this semester. We are currently working on increasing performance -- please accept our apologies for the technical difficulties.
You can help reduce stress on the server by:
- not reloading pages frequently - this just adds
- opening links in new windows (so you can read the old page)
MGI:L1cam
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | L1cam ( synonyms: CD171, L1, L1-NCAM, NCAM-L1 ) | |
| Protein Name(s) | L1 cell adhesion molecule, | |
| External Links | ||
| MGI | MGI:96721 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0005178 |
integrin binding |
MGI:MGI:3757617 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3706622 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3801368 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:74049 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:85772 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005624 |
membrane fraction |
MGI:MGI:3706622 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0007156 |
homophilic cell adhesion |
MGI:MGI:3757619 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0007157 |
heterophilic cell-cell adhesion |
MGI:MGI:3757617 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0007159 |
leukocyte cell-cell adhesion |
MGI:MGI:3757617 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0007159 |
leukocyte cell-cell adhesion |
MGI:MGI:3757623 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0007166 |
cell surface receptor signaling pathway |
MGI:MGI:74049 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007411 |
axon guidance |
MGI:MGI:2449891 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857443 |
P |
From MGI |
||
| GO:0007411 |
axon guidance |
MGI:MGI:3801368 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:104518 |
P |
From MGI |
||
| GO:0007411 |
axon guidance |
MGI:MGI:3801368 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857443 |
P |
From MGI |
||
| GO:0007411 |
axon guidance |
MGI:MGI:3804601 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:65397 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:74049 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009986 |
cell surface |
MGI:MGI:3032463 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0022409 |
positive regulation of cell-cell adhesion |
MGI:MGI:3757619 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0030165 |
PDZ domain binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0031175 |
neuron projection development |
MGI:MGI:3706622 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0031175 |
neuron projection development |
MGI:MGI:3706622 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2181735 |
P |
From MGI |
||
| GO:0033631 |
cell-cell adhesion mediated by integrin |
MGI:MGI:3757617 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0033691 |
sialic acid binding |
MGI:MGI:3706622 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0033691 |
sialic acid binding |
MGI:MGI:4438147 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0034109 |
homotypic cell-cell adhesion |
MGI:MGI:74049 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0042734 |
presynaptic membrane |
MGI:MGI:3619851 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0042802 |
identical protein binding |
MGI:MGI:3757617 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0042802 |
identical protein binding |
MGI:MGI:85772 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0043195 |
terminal button |
MGI:MGI:3619851 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0043621 |
protein self-association |
MGI:MGI:3801368 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0050850 |
positive regulation of calcium-mediated signaling |
MGI:MGI:74049 |
IDA: Inferred from Direct Assay |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Ruppert M et al. (1995) The L1 adhesion molecule is a cellular ligand for VLA-5. J Cell Biol 131: 1881-91 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 Kleene R et al. (2001) The neural recognition molecule L1 is a sialic acid-binding lectin for CD24, which induces promotion and inhibition of neurite outgrowth. J Biol Chem 276: 21656-63 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Law CO et al. (2008) The neural adhesion molecule TAG-1 modulates responses of sensory axons to diffusible guidance signals. Development 135: 2361-71 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 Kadmon G et al. (1995) Evidence for cis interaction and cooperative signalling by the heat-stable antigen nectadrin (murine CD24) and the cell adhesion molecule L1 in neurons. Eur J Neurosci 7: 993-1004 PubMed GONUTS page
- ↑ 5.0 5.1 Sammar M et al. (1997) Heat-stable antigen (mouse CD24) in the brain: dual but distinct interaction with P-selectin and L1. Biochim Biophys Acta 1337: 287-94 PubMed GONUTS page
- ↑ 6.0 6.1 Kadmon G et al. (1995) Adhesive hierarchy involving the cell adhesion molecules L1, CD24, and alpha 6 integrin in murine neuroblastoma N2A cells. Biochem Biophys Res Commun 214: 94-101 PubMed GONUTS page
- ↑ Kadmon G et al. (1994) Differential, LFA-1-sensitive effects of antibodies to nectadrin, the heat-stable antigen, on B lymphoblast aggregation and signal transduction. Biochem Biophys Res Commun 198: 1209-15 PubMed GONUTS page
- ↑ Demyanenko GP & Maness PF (2003) The L1 cell adhesion molecule is essential for topographic mapping of retinal axons. J Neurosci 23: 530-8 PubMed GONUTS page
- ↑ Chatzopoulou E et al. (2008) Structural requirement of TAG-1 for retinal ganglion cell axons and myelin in the mouse optic nerve. J Neurosci 28: 7624-36 PubMed GONUTS page
- ↑ Hubbe M & Altevogt P (1994) Heat-stable antigen/CD24 on mouse T lymphocytes: evidence for a costimulatory function. Eur J Immunol 24: 731-7 PubMed GONUTS page
- ↑ Rünker AE et al. (2003) The C264Y missense mutation in the extracellular domain of L1 impairs protein trafficking in vitro and in vivo. J Neurosci 23: 277-86 PubMed GONUTS page
- ↑ Lieberoth A et al. (2009) Lewis(x) and alpha2,3-sialyl glycans and their receptors TAG-1, Contactin, and L1 mediate CD24-dependent neurite outgrowth. J Neurosci 29: 6677-90 PubMed GONUTS page
- ↑ 13.0 13.1 Nakamura Y et al. (2006) Role of neuropsin in formation and maturation of Schaffer-collateral L1cam-immunoreactive synaptic boutons. J Cell Sci 119: 1341-9 PubMed GONUTS page
