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MGI:Krit1
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Krit1 ( synonyms: Ccm1, Krit1, Krit1A, Krit1B ) | |
| Protein Name(s) | KRIT1, ankyrin repeat containing, | |
| External Links | ||
| MGI | MGI:1930618 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001525 |
angiogenesis |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0037 |
P |
From MGI |
||
| GO:0001937 |
negative regulation of endothelial cell proliferation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0005083 |
small GTPase regulator activity |
MGI:MGI:1929578 |
TAS: Traceable Author Statement |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3837878 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:4943403 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005856 |
cytoskeleton |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0005911 |
cell-cell junction |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0010596 |
negative regulation of endothelial cell migration |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016525 |
negative regulation of angiogenesis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0016525 |
negative regulation of angiogenesis |
MGI:MGI:4943808 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0030054 |
cell junction |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0965 |
C |
From MGI |
||
| GO:0032092 |
positive regulation of protein binding |
MGI:MGI:3837878 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0043234 |
protein complex |
MGI:MGI:3837878 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0045454 |
cell redox homeostasis |
MGI:MGI:4821024 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0045454 |
cell redox homeostasis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:2000114 |
regulation of establishment of cell polarity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:2000114 |
regulation of establishment of cell polarity |
MGI:MGI:4943837 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:2000352 |
negative regulation of endothelial cell apoptotic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Sahoo T et al. (2001) Computational and experimental analyses reveal previously undetected coding exons of the KRIT1 (CCM1) gene. Genomics 71: 123-6 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Kleaveland B et al. (2009) Regulation of cardiovascular development and integrity by the heart of glass-cerebral cavernous malformation protein pathway. Nat Med 15: 169-76 PubMed GONUTS page
- ↑ Czubayko M et al. (2006) Sorting nexin 17, a non-self-assembling and a PtdIns(3)P high class affinity protein, interacts with the cerebral cavernous malformation related protein KRIT1. Biochem Biophys Res Commun 345: 1264-72 PubMed GONUTS page
- ↑ Wüstehube J et al. (2010) Cerebral cavernous malformation protein CCM1 inhibits sprouting angiogenesis by activating DELTA-NOTCH signaling. Proc Natl Acad Sci U S A 107: 12640-5 PubMed GONUTS page
- ↑ Goitre L et al. (2010) KRIT1 regulates the homeostasis of intracellular reactive oxygen species. PLoS One 5: e11786 PubMed GONUTS page
- ↑ Lampugnani MG et al. (2010) CCM1 regulates vascular-lumen organization by inducing endothelial polarity. J Cell Sci 123: 1073-80 PubMed GONUTS page
