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MGI:Kras
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Kras ( synonyms: K-ras, Ki-ras, Kras-2, Kras2 ) | |
| Protein Name(s) | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, | |
| External Links | ||
| MGI | MGI:96680 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000166 |
nucleotide binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0547 |
F |
From MGI |
||
| GO:0001934 |
positive regulation of protein phosphorylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0003924 |
GTPase activity |
MGI:MGI:1346977 |
TAS: Traceable Author Statement |
F |
From MGI |
|||
| GO:0003924 |
GTPase activity |
MGI:MGI:3526457 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:97306 |
F |
From MGI |
||
| GO:0005515 |
protein binding |
MGI:MGI:3688344 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:4821068 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005525 |
GTP binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0342 |
F |
From MGI |
||
| GO:0005525 |
GTP binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:1346977 |
TAS: Traceable Author Statement |
C |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:3526457 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:97306 |
C |
From MGI |
||
| GO:0005624 |
membrane fraction |
MGI:MGI:1333599 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005624 |
membrane fraction |
MGI:MGI:3029624 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1888594 |
C |
From MGI |
||
| GO:0005739 |
mitochondrion |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-1003 |
C |
From MGI |
||
| GO:0007165 |
signal transduction |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0007264 |
small GTPase mediated signal transduction |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0007265 |
Ras protein signal transduction |
MGI:MGI:1346977 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0007265 |
Ras protein signal transduction |
MGI:MGI:3526457 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:97306 |
P |
From MGI |
||
| GO:0008284 |
positive regulation of cell proliferation |
MGI:MGI:3526457 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:97306 |
P |
From MGI |
||
| GO:0008542 |
visual learning |
MGI:MGI:2157992 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:97306 |
P |
From MGI |
||
| GO:0010628 |
positive regulation of gene expression |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016020 |
membrane |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0019002 |
GMP binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0019003 |
GDP binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0019221 |
cytokine-mediated signaling pathway |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030036 |
actin cytoskeleton organization |
MGI:MGI:3526457 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:97306 |
P |
From MGI |
||
| GO:0030275 |
LRR domain binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0032228 |
regulation of synaptic transmission, GABAergic |
MGI:MGI:2157992 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:97306 |
P |
From MGI |
||
| GO:0035022 |
positive regulation of Rac protein signal transduction |
MGI:MGI:3526457 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:97306 |
P |
From MGI |
||
| GO:0043406 |
positive regulation of MAP kinase activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043524 |
negative regulation of neuron apoptotic process |
MGI:MGI:1861510 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:97306 |
P |
From MGI |
||
| GO:0045121 |
membrane raft |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0048169 |
regulation of long-term neuronal synaptic plasticity |
MGI:MGI:2157992 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:97306 |
P |
From MGI |
||
| GO:0051000 |
positive regulation of nitric-oxide synthase activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0051092 |
positive regulation of NF-kappaB transcription factor activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0051146 |
striated muscle cell differentiation |
MGI:MGI:3511080 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:97874 |
P |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Adams JM et al. (1999) Transgenic models of lymphoid neoplasia and development of a pan-hematopoietic vector. Oncogene 18: 5268-77 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Dasgupta B et al. (2005) Glioma formation in neurofibromatosis 1 reflects preferential activation of K-RAS in astrocytes. Cancer Res 65: 236-45 PubMed GONUTS page
- ↑ Papin J & Subramaniam S (2004) Bioinformatics and cellular signaling. Curr Opin Biotechnol 15: 78-81 PubMed GONUTS page
- ↑ Allen NP et al. (2007) RASSF6 is a novel member of the RASSF family of tumor suppressors. Oncogene 26: 6203-11 PubMed GONUTS page
- ↑ Kim E et al. (1999) Disruption of the mouse Rce1 gene results in defective Ras processing and mislocalization of Ras within cells. J Biol Chem 274: 8383-90 PubMed GONUTS page
- ↑ Bergo MO et al. (2004) Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf. J Clin Invest 113: 539-50 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 Costa RM et al. (2002) Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1. Nature 415: 526-30 PubMed GONUTS page
- ↑ Vogel KS et al. (2000) Neurofibromin negatively regulates neurotrophin signaling through p21ras in embryonic sensory neurons. Mol Cell Neurosci 15: 398-407 PubMed GONUTS page
- ↑ Takahashi C et al. (2004) Genetic interaction between Rb and K-ras in the control of differentiation and tumor suppression. Mol Cell Biol 24: 10406-15 PubMed GONUTS page
