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MGI:Klrk1
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Klrk1 ( synonyms: D6H12S2489E, NKG2-D, Nkg2d ) | |
| Protein Name(s) | killer cell lectin-like receptor subfamily K, member 1, | |
| External Links | ||
| MGI | MGI:1196250 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0002223 |
stimulatory C-type lectin receptor signaling pathway |
MGI:MGI:2450811 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0004872 |
receptor activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0675 |
F |
From MGI |
||
| GO:0005515 |
protein binding |
MGI:MGI:2450811 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3037535 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:2450811 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:2687118 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:3028810 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:3686949 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009986 |
cell surface |
MGI:MGI:3037535 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016021 |
integral to membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0812 |
C |
From MGI |
||
| GO:0030101 |
natural killer cell activation |
MGI:MGI:2450811 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0030101 |
natural killer cell activation |
MGI:MGI:3773822 |
IPI: Inferred from Physical Interaction |
UniProtKB:Q3TM01 |
P |
From MGI |
||
| GO:0030246 |
carbohydrate binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0032394 |
MHC class Ib receptor activity |
MGI:MGI:2450811 |
IMP: Inferred from Mutant Phenotype |
F |
From MGI |
|||
| GO:0032729 |
positive regulation of interferon-gamma production |
MGI:MGI:2450811 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0042288 |
MHC class I protein binding |
MGI:MGI:3773822 |
IPI: Inferred from Physical Interaction |
UniProtKB:B1B212 |
F |
From MGI |
||
| GO:0042803 |
protein homodimerization activity |
MGI:MGI:3037535 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0045429 |
positive regulation of nitric oxide biosynthetic process |
MGI:MGI:2450811 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045954 |
positive regulation of natural killer cell mediated cytotoxicity |
MGI:MGI:2450811 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0050830 |
defense response to Gram-positive bacterium |
MGI:MGI:3028810 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0071222 |
cellular response to lipopolysaccharide |
MGI:MGI:3028810 |
IDA: Inferred from Direct Assay |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Diefenbach A et al. (2003) A novel ligand for the NKG2D receptor activates NK cells and macrophages and induces tumor immunity. Eur J Immunol 33: 381-91 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Girardi M et al. (2001) Regulation of cutaneous malignancy by gammadelta T cells. Science 294: 605-9 PubMed GONUTS page
- ↑ Koike J et al. (2004) Bone marrow allograft rejection mediated by a novel murine NK receptor, NKG2I. J Exp Med 199: 137-44 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Hamerman JA et al. (2004) Cutting edge: Toll-like receptor signaling in macrophages induces ligands for the NKG2D receptor. J Immunol 172: 2001-5 PubMed GONUTS page
- ↑ Marie JC et al. (2006) Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor. Immunity 25: 441-54 PubMed GONUTS page
- ↑ 6.0 6.1 Takada A et al. (2008) Two novel NKG2D ligands of the mouse H60 family with differential expression patterns and binding affinities to NKG2D. J Immunol 180: 1678-85 PubMed GONUTS page
