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MGI:Klk8
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Klk8 ( synonyms: BSP1, Nrpn, Prss19 ) | |
| Protein Name(s) | kallikrein related-peptidase 8, | |
| External Links | ||
| MGI | MGI:1343327 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0003824 |
catalytic activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0004252 |
serine-type endopeptidase activity |
MGI:MGI:3770569 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004252 |
serine-type endopeptidase activity |
MGI:MGI:3770577 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004252 |
serine-type endopeptidase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005576 |
extracellular region |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0964 |
C |
From MGI |
||
| GO:0005615 |
extracellular space |
MGI:MGI:3770577 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4835404 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0006508 |
proteolysis |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0645 |
P |
From MGI |
||
| GO:0006508 |
proteolysis |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0007613 |
memory |
MGI:MGI:3770567 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0008152 |
metabolic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0008219 |
cell death |
MGI:MGI:3766680 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0008233 |
peptidase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0645 |
F |
From MGI |
||
| GO:0008236 |
serine-type peptidase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0720 |
F |
From MGI |
||
| GO:0009611 |
response to wounding |
MGI:MGI:3770574 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0009611 |
response to wounding |
MGI:MGI:3770575 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0009611 |
response to wounding |
MGI:MGI:3770594 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0016787 |
hydrolase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0378 |
F |
From MGI |
||
| GO:0031642 |
negative regulation of myelination |
MGI:MGI:3766680 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0043616 |
keratinocyte proliferation |
MGI:MGI:3708194 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0048681 |
negative regulation of axon regeneration |
MGI:MGI:3766680 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0048812 |
neuron projection morphogenesis |
MGI:MGI:3770572 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0050807 |
regulation of synapse organization |
MGI:MGI:1933027 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0050808 |
synapse organization |
MGI:MGI:3619851 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2678312 |
P |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Matsumoto-Miyai K et al. (2003) NMDA-dependent proteolysis of presynaptic adhesion molecule L1 in the hippocampus by neuropsin. J Neurosci 23: 7727-36 PubMed GONUTS page
- ↑ 2.0 2.1 Shimizu C et al. (1998) Characterization of recombinant and brain neuropsin, a plasticity-related serine protease. J Biol Chem 273: 11189-96 PubMed GONUTS page
- ↑ Scott FL et al. (2007) SerpinB6 is an inhibitor of kallikrein-8 in keratinocytes. J Biochem 142: 435-42 PubMed GONUTS page
- ↑ Tamura H et al. (2006) Neuropsin is essential for early processes of memory acquisition and Schaffer collateral long-term potentiation in adult mouse hippocampus in vivo. J Physiol 570: 541-51 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Terayama R et al. (2007) Neuropsin promotes oligodendrocyte death, demyelination and axonal degeneration after spinal cord injury. Neuroscience 148: 175-87 PubMed GONUTS page
- ↑ Kitayoshi H et al. (1999) Effect of 12-O-tetradecanoyl-phorbol ester and incisional wounding on neuropsin mRNA and its protein expression in murine skin. Arch Dermatol Res 291: 333-8 PubMed GONUTS page
- ↑ Tomizawa K et al. (1999) Injury induces neuropsin mRNA in the central nervous system. Brain Res 824: 308-11 PubMed GONUTS page
- ↑ He XP et al. (2001) Expression of neuropsin in oligodendrocytes after injury to the CNS. Neurosci Res 39: 455-62 PubMed GONUTS page
- ↑ Kishibe M et al. (2007) Kallikrein 8 is involved in skin desquamation in cooperation with other kallikreins. J Biol Chem 282: 5834-41 PubMed GONUTS page
- ↑ Oka T et al. (2002) Extracellular serine protease neuropsin (KLK8) modulates neurite outgrowth and fasciculation of mouse hippocampal neurons in culture. Neurosci Lett 321: 141-4 PubMed GONUTS page
- ↑ Hirata A et al. (2001) Abnormalities of synapses and neurons in the hippocampus of neuropsin-deficient mice. Mol Cell Neurosci 17: 600-10 PubMed GONUTS page
- ↑ Nakamura Y et al. (2006) Role of neuropsin in formation and maturation of Schaffer-collateral L1cam-immunoreactive synaptic boutons. J Cell Sci 119: 1341-9 PubMed GONUTS page
