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MGI:Klf1

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Contents

Species (Taxon ID) Mus musculus (house mouse) (taxon:10090)
Gene Name(s) Klf1 ( synonyms: Eklf, Nan )
Protein Name(s) Kruppel-like factor 1 (erythroid),
External Links
MGI MGI:1342771

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000790

nuclear chromatin

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q13351

C

From MGI

GO:0000987

core promoter proximal region sequence-specific DNA binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q13351

F

From MGI

GO:0001701

in utero embryonic development

MGI:MGI:73364
PMID:7753194[1]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857557

P

From MGI

GO:0001889

liver development

MGI:MGI:73364
PMID:7753194[1]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857557

P

From MGI

GO:0003677

DNA binding

MGI:MGI:3575608
PMID:15820306[2]

ISS: Inferred from Sequence or Structural Similarity

F

From MGI

GO:0005634

nucleus

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q13351

C

From MGI

GO:0006338

chromatin remodeling

MGI:MGI:3056025
PMID:15489291[3]

IDA: Inferred from Direct Assay

P

From MGI

GO:0030218

erythrocyte differentiation

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q13351

P

From MGI

GO:0035162

embryonic hemopoiesis

MGI:MGI:4819250
PMID:19409822[4]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1861107

P

From MGI

GO:0035162

embryonic hemopoiesis

MGI:MGI:73364
PMID:7753194[1]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857557

P

From MGI

GO:0043249

erythrocyte maturation

MGI:MGI:73365
PMID:7753195[5]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0044212

transcription regulatory region DNA binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q13351

F

From MGI

GO:0045893

positive regulation of transcription, DNA-dependent

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q13351

P

From MGI

GO:0048821

erythrocyte development

MGI:MGI:3581371
PMID:15923635[6]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857162

P

From MGI

GO:0048821

erythrocyte development

MGI:MGI:73364
PMID:7753194[1]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857557

P

From MGI


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 1.2 1.3 Nuez B et al. (1995) Defective haematopoiesis in fetal liver resulting from inactivation of the EKLF gene. Nature 375: 316-8 PubMed GONUTS page
  2. Suske G et al. (2005) Mammalian SP/KLF transcription factors: bring in the family. Genomics 85: 551-6 PubMed GONUTS page
  3. Drissen R et al. (2004) The active spatial organization of the beta-globin locus requires the transcription factor EKLF. Genes Dev 18: 2485-90 PubMed GONUTS page
  4. White RA et al. (2009) Hematologic characterization and chromosomal localization of the novel dominantly inherited mouse hemolytic anemia, neonatal anemia (Nan). Blood Cells Mol Dis 43: 141-8 PubMed GONUTS page
  5. Perkins AC et al. (1995) Lethal beta-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF. Nature 375: 318-22 PubMed GONUTS page
  6. Drissen R et al. (2005) The erythroid phenotype of EKLF-null mice: defects in hemoglobin metabolism and membrane stability. Mol Cell Biol 25: 5205-14 PubMed GONUTS page
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