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MGI:Kl
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Kl ( synonyms: alpha-kl ) | |
| Protein Name(s) | klotho, | |
| External Links | ||
| MGI | MGI:1101771 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0002526 |
acute inflammatory response |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_112626 |
P |
From MGI |
||
| GO:0003824 |
catalytic activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0004553 |
hydrolase activity, hydrolyzing O-glycosyl compounds |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0004566 |
beta-glucuronidase activity |
MGI:MGI:2152096 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005104 |
fibroblast growth factor receptor binding |
MGI:MGI:3696596 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3718804 |
IPI: Inferred from Physical Interaction |
UniProtKB:P04426 |
F |
From MGI |
||
| GO:0005576 |
extracellular region |
MGI:MGI:1197786 |
ISS: Inferred from Sequence or Structural Similarity |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-1003 |
C |
From MGI |
||
| GO:0005975 |
carbohydrate metabolic process |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0006112 |
energy reserve metabolic process |
MGI:MGI:1927946 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1889570 |
P |
From MGI |
||
| GO:0007568 |
aging |
MGI:MGI:1099360 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1889570 |
P |
From MGI |
||
| GO:0007568 |
aging |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0008152 |
metabolic process |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0326 |
P |
From MGI |
||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016021 |
integral to membrane |
MGI:MGI:1197786 |
ISS: Inferred from Sequence or Structural Similarity |
C |
From MGI |
|||
| GO:0016787 |
hydrolase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0378 |
F |
From MGI |
||
| GO:0016798 |
hydrolase activity, acting on glycosyl bonds |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0326 |
F |
From MGI |
||
| GO:0017134 |
fibroblast growth factor binding |
MGI:MGI:3696596 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0017134 |
fibroblast growth factor binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0030501 |
positive regulation of bone mineralization |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043169 |
cation binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0090080 |
positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway |
MGI:MGI:3640642 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1890427 |
P |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Urakawa I et al. (2006) Klotho converts canonical FGF receptor into a specific receptor for FGF23. Nature 444: 770-4 PubMed GONUTS page
- ↑ Liu H et al. (2007) Augmented Wnt signaling in a mammalian model of accelerated aging. Science 317: 803-6 PubMed GONUTS page
- ↑ 3.0 3.1 Shiraki-Iida T et al. (1998) Structure of the mouse klotho gene and its two transcripts encoding membrane and secreted protein. FEBS Lett 424: 6-10 PubMed GONUTS page
- ↑ Mori K et al. (2000) Disruption of klotho gene causes an abnormal energy homeostasis in mice. Biochem Biophys Res Commun 278: 665-70 PubMed GONUTS page
- ↑ Kuro-o M et al. (1997) Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 390: 45-51 PubMed GONUTS page
- ↑ Kurosu H et al. (2006) Regulation of fibroblast growth factor-23 signaling by klotho. J Biol Chem 281: 6120-3 PubMed GONUTS page
