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MGI:Kirrel

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Contents

Species (Taxon ID) Mus musculus (house mouse) (taxon:10090)
Gene Name(s) Kirrel ( synonyms: Kirrel1, Neph1 )
Protein Name(s) kin of IRRE like (Drosophila),
External Links
MGI MGI:1891396

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0001933

negative regulation of protein phosphorylation

MGI:MGI:4950838
PMID:21306299[1]

IGI: Inferred from Genetic Interaction

MGI:MGI:2442334

P

From MGI

GO:0005515

protein binding

MGI:MGI:3768467
PMID:17923684[2]

IPI: Inferred from Physical Interaction

UniProtKB:P62994
UniProtKB:Q62844
UniProtKB:P39688

F

From MGI

GO:0005515

protein binding

MGI:MGI:4453906
PMID:20233749[3]

IPI: Inferred from Physical Interaction

UniProtKB:Q9QY53

F

From MGI

GO:0005886

plasma membrane

MGI:MGI:3768467
PMID:17923684[2]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005911

cell-cell junction

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_997489

C

From MGI

GO:0005911

cell-cell junction

MGI:MGI:4950838
PMID:21306299[1]

IDA: Inferred from Direct Assay

C

From MGI

GO:0007588

excretion

MGI:MGI:2157763
PMID:11416156[4]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2388348

P

From MGI

GO:0016020

membrane

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

From MGI

GO:0016021

integral to membrane

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0812

C

From MGI

GO:0016337

cell-cell adhesion

MGI:MGI:4950838
PMID:21306299[1]

IDA: Inferred from Direct Assay

P

From MGI

GO:0016337

cell-cell adhesion

MGI:MGI:4950838
PMID:21306299[1]

IGI: Inferred from Genetic Interaction

MGI:MGI:2442334
MGI:MGI:1859637

P

From MGI

GO:0030838

positive regulation of actin filament polymerization

MGI:MGI:3768467
PMID:17923684[2]

IGI: Inferred from Genetic Interaction

MGI:MGI:95805
MGI:MGI:1859637
MGI:MGI:109601

P

From MGI

GO:0031253

cell projection membrane

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_997489

C

From MGI

GO:0043198

dendritic shaft

MGI:MGI:3839100
PMID:16874800[5]

IDA: Inferred from Direct Assay

C

From MGI


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 1.2 1.3 Heikkilä E et al. (2011) Trans-interaction of nephrin and Neph1/Neph3 induces cell adhesion that associates with decreased tyrosine phosphorylation of nephrin. Biochem J 435: 619-28 PubMed GONUTS page
  2. 2.0 2.1 2.2 Garg P et al. (2007) Neph1 cooperates with nephrin to transduce a signal that induces actin polymerization. Mol Cell Biol 27: 8698-712 PubMed GONUTS page
  3. Neumann-Haefelin E et al. (2010) A model organism approach: defining the role of Neph proteins as regulators of neuron and kidney morphogenesis. Hum Mol Genet 19: 2347-59 PubMed GONUTS page
  4. Donoviel DB et al. (2001) Proteinuria and perinatal lethality in mice lacking NEPH1, a novel protein with homology to NEPHRIN. Mol Cell Biol 21: 4829-36 PubMed GONUTS page
  5. Gerke P et al. (2006) Neuronal expression and interaction with the synaptic protein CASK suggest a role for Neph1 and Neph2 in synaptogenesis. J Comp Neurol 498: 466-75 PubMed GONUTS page
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