MGI:Kdr

From GONUTS

Jump to: navigation, search

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000166	nucleotide binding	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0547	F	From MGI
	GO:0001541	ovarian follicle development	MGI:MGI:3709459 PMID:17050862^[1]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0001570	vasculogenesis	MGI:MGI:3529425 PMID:15644447^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3530468	P	From MGI
	GO:0001666	response to hypoxia	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:O08775	P	From MGI
	GO:0001938	positive regulation of endothelial cell proliferation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35968	P	From MGI
	GO:0001945	lymph vessel development	MGI:MGI:4443218 PMID:20439428^[3]	IGI: Inferred from Genetic Interaction	MGI:MGI:3039635	P	From MGI
	GO:0002053	positive regulation of mesenchymal cell proliferation	MGI:MGI:3613102 PMID:16375885^[4]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0004713	protein tyrosine kinase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35968	F	From MGI
	GO:0004872	receptor activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0675	F	From MGI
	GO:0005021	vascular endothelial growth factor-activated receptor activity	MGI:MGI:3047093 PMID:8356051^[5]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0005021	vascular endothelial growth factor-activated receptor activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:O08775	F	From MGI
	GO:0005021	vascular endothelial growth factor-activated receptor activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35968	F	From MGI
	GO:0005178	integrin binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35968	F	From MGI
	GO:0005524	ATP binding	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0067	F	From MGI
	GO:0005624	membrane fraction	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:O08775	C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:O08775	C	From MGI
	GO:0005886	plasma membrane	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:O08775	C	From MGI
	GO:0005887	integral to plasma membrane	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35968	C	From MGI
	GO:0007204	elevation of cytosolic calcium ion concentration	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:O08775	P	From MGI
	GO:0008284	positive regulation of cell proliferation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:O08775	P	From MGI
	GO:0008284	positive regulation of cell proliferation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35968	P	From MGI
	GO:0008360	regulation of cell shape	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35968	P	From MGI
	GO:0008584	male gonad development	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:O08775	P	From MGI
	GO:0009897	external side of plasma membrane	MGI:MGI:4415813 PMID:18462699^[6]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0009897	external side of plasma membrane	MGI:MGI:4453910 PMID:20228271^[7]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0010595	positive regulation of endothelial cell migration	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35968	P	From MGI
	GO:0014068	positive regulation of phosphatidylinositol 3-kinase cascade	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:O08775	P	From MGI
	GO:0014068	positive regulation of phosphatidylinositol 3-kinase cascade	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35968	P	From MGI
	GO:0016020	membrane	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0472	C	From MGI
	GO:0016021	integral to membrane	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0812	C	From MGI
	GO:0016301	kinase activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0418	F	From MGI
	GO:0016310	phosphorylation	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0418	P	From MGI
	GO:0016477	cell migration	MGI:MGI:3525930 PMID:15601856^[8]	IGI: Inferred from Genetic Interaction	MGI:MGI:103178	P	From MGI
	GO:0016740	transferase activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0808	F	From MGI
	GO:0018108	peptidyl-tyrosine phosphorylation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35968	P	From MGI
	GO:0019838	growth factor binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:O08775	F	From MGI
	GO:0019838	growth factor binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35968	F	From MGI
	GO:0019838	growth factor binding	MGI:MGI:83765 PMID:7681362^[9]	IPI: Inferred from Physical Interaction	UniProtKB:P15692	F	From MGI
	GO:0030097	hemopoiesis	MGI:MGI:3529425 PMID:15644447^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3530468	P	From MGI
	GO:0030324	lung development	MGI:MGI:3613102 PMID:16375885^[4]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0030335	positive regulation of cell migration	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:O08775	P	From MGI
	GO:0030335	positive regulation of cell migration	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35968	P	From MGI
	GO:0032008	positive regulation of TOR signaling cascade	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:O08775	P	From MGI
	GO:0035584	calcium-mediated signaling using intracellular calcium source	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35968	P	From MGI
	GO:0035924	cellular response to vascular endothelial growth factor stimulus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35968	P	From MGI
	GO:0038084	vascular endothelial growth factor signaling pathway	MGI:MGI:3047093 PMID:8356051^[5]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0038084	vascular endothelial growth factor signaling pathway	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:O08775	P	From MGI
	GO:0038084	vascular endothelial growth factor signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35968	P	From MGI
	GO:0038085	vascular endothelial growth factor binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35968	F	From MGI
	GO:0042221	response to chemical stimulus	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:O08775	P	From MGI
	GO:0043005	neuron projection	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:O08775	C	From MGI
	GO:0043025	neuronal cell body	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:O08775	C	From MGI
	GO:0043066	negative regulation of apoptotic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35968	P	From MGI
	GO:0043129	surfactant homeostasis	MGI:MGI:2181852 PMID:12053176^[10]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0043410	positive regulation of MAPK cascade	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35968	P	From MGI
	GO:0043526	neuroprotection	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:O08775	P	From MGI
	GO:0045165	cell fate commitment	MGI:MGI:2450018 PMID:12569129^[11]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0045446	endothelial cell differentiation	MGI:MGI:2670246 PMID:12897140^[12]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045766	positive regulation of angiogenesis	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:O08775	P	From MGI
	GO:0045766	positive regulation of angiogenesis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35968	P	From MGI
	GO:0045909	positive regulation of vasodilation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:O08775	P	From MGI
	GO:0046777	protein autophosphorylation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:O08775	P	From MGI
	GO:0046777	protein autophosphorylation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35968	P	From MGI
	GO:0048010	vascular endothelial growth factor receptor signaling pathway	MGI:MGI:3047093 PMID:8356051^[5]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0048010	vascular endothelial growth factor receptor signaling pathway	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:O08775	P	From MGI
	GO:0048010	vascular endothelial growth factor receptor signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35968	P	From MGI
	GO:0048170	positive regulation of long-term neuronal synaptic plasticity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:O08775	P	From MGI
	GO:0048286	lung alveolus development	MGI:MGI:2181852 PMID:12053176^[10]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0048469	cell maturation	MGI:MGI:2181852 PMID:12053176^[10]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0048754	branching morphogenesis of a tube	MGI:MGI:3613102 PMID:16375885^[4]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0048812	neuron projection morphogenesis	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:O08775	P	From MGI
	GO:0050679	positive regulation of epithelial cell proliferation	MGI:MGI:3613102 PMID:16375885^[4]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0050850	positive regulation of calcium-mediated signaling	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:O08775	P	From MGI
	GO:0050927	positive regulation of positive chemotaxis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35968	P	From MGI
	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35968	P	From MGI
	GO:0051894	positive regulation of focal adhesion assembly	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35968	P	From MGI
	GO:0055074	calcium ion homeostasis	MGI:MGI:3047093 PMID:8356051^[5]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0070374	positive regulation of ERK1 and ERK2 cascade	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35968	P	From MGI
	GO:0071944	cell periphery	MGI:MGI:3611394 PMID:16099728^[13]	IDA: Inferred from Direct Assay		C	From MGI
	GO:2000352	negative regulation of endothelial cell apoptotic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P35968	P	From MGI
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Roberts AE et al. (2007) Neutralization of endogenous vascular endothelial growth factor depletes primordial follicles in the mouse ovary. Biol Reprod 76: 218-23 PubMed GONUTS page
↑ ^2.0 ^2.1 Sakurai Y et al. (2005) Essential role of Flk-1 (VEGF receptor 2) tyrosine residue 1173 in vasculogenesis in mice. Proc Natl Acad Sci U S A 102: 1076-81 PubMed GONUTS page
↑ Saharinen P et al. (2010) Claudin-like protein 24 interacts with the VEGFR-2 and VEGFR-3 pathways and regulates lymphatic vessel development. Genes Dev 24: 875-80 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Del Moral PM et al. (2006) VEGF-A signaling through Flk-1 is a critical facilitator of early embryonic lung epithelial to endothelial crosstalk and branching morphogenesis. Dev Biol 290: 177-88 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Quinn TP et al. (1993) Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium. Proc Natl Acad Sci U S A 90: 7533-7 PubMed GONUTS page
↑ Lee D et al. (2008) ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification. Cell Stem Cell 2: 497-507 PubMed GONUTS page
↑ Serrano AG et al. (2010) Contrasting effects of Sox17- and Sox18-sustained expression at the onset of blood specification. Blood 115: 3895-8 PubMed GONUTS page
↑ Hiratsuka S et al. (2005) Vascular endothelial growth factor A (VEGF-A) is involved in guidance of VEGF receptor-positive cells to the anterior portion of early embryos. Mol Cell Biol 25: 355-63 PubMed GONUTS page
↑ Millauer B et al. (1993) High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis. Cell 72: 835-46 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Compernolle V et al. (2002) Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice. Nat Med 8: 702-10 PubMed GONUTS page
↑ Ema M et al. (2003) Combinatorial effects of Flk1 and Tal1 on vascular and hematopoietic development in the mouse. Genes Dev 17: 380-93 PubMed GONUTS page
↑ Wu Y et al. (2003) HoxB5 is an upstream transcriptional switch for differentiation of the vascular endothelium from precursor cells. Mol Cell Biol 23: 5680-91 PubMed GONUTS page
↑ Siva K & Inamdar MS (2006) Rudhira is a cytoplasmic WD40 protein expressed in mouse embryonic stem cells and during embryonic erythropoiesis. Gene Expr Patterns 6: 225-34 PubMed GONUTS page

[PMID:17050862-0] Roberts AE et al. (2007) Neutralization of endogenous vascular endothelial growth factor depletes primordial follicles in the mouse ovary. Biol Reprod 76: 218-23 PubMed GONUTS page

[PMID:15644447-1] 2.0 ^2.1 Sakurai Y et al. (2005) Essential role of Flk-1 (VEGF receptor 2) tyrosine residue 1173 in vasculogenesis in mice. Proc Natl Acad Sci U S A 102: 1076-81 PubMed GONUTS page

[PMID:20439428-2] Saharinen P et al. (2010) Claudin-like protein 24 interacts with the VEGFR-2 and VEGFR-3 pathways and regulates lymphatic vessel development. Genes Dev 24: 875-80 PubMed GONUTS page

[PMID:16375885-3] 4.0 ^4.1 ^4.2 ^4.3 Del Moral PM et al. (2006) VEGF-A signaling through Flk-1 is a critical facilitator of early embryonic lung epithelial to endothelial crosstalk and branching morphogenesis. Dev Biol 290: 177-88 PubMed GONUTS page

[PMID:8356051-4] 5.0 ^5.1 ^5.2 ^5.3 Quinn TP et al. (1993) Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium. Proc Natl Acad Sci U S A 90: 7533-7 PubMed GONUTS page

[PMID:18462699-5] Lee D et al. (2008) ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification. Cell Stem Cell 2: 497-507 PubMed GONUTS page

[PMID:20228271-6] Serrano AG et al. (2010) Contrasting effects of Sox17- and Sox18-sustained expression at the onset of blood specification. Blood 115: 3895-8 PubMed GONUTS page

[PMID:15601856-7] Hiratsuka S et al. (2005) Vascular endothelial growth factor A (VEGF-A) is involved in guidance of VEGF receptor-positive cells to the anterior portion of early embryos. Mol Cell Biol 25: 355-63 PubMed GONUTS page

[PMID:7681362-8] Millauer B et al. (1993) High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis. Cell 72: 835-46 PubMed GONUTS page

[PMID:12053176-9] 10.0 ^10.1 ^10.2 Compernolle V et al. (2002) Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice. Nat Med 8: 702-10 PubMed GONUTS page

[PMID:12569129-10] Ema M et al. (2003) Combinatorial effects of Flk1 and Tal1 on vascular and hematopoietic development in the mouse. Genes Dev 17: 380-93 PubMed GONUTS page

[PMID:12897140-11] Wu Y et al. (2003) HoxB5 is an upstream transcriptional switch for differentiation of the vascular endothelium from precursor cells. Mol Cell Biol 23: 5680-91 PubMed GONUTS page

[PMID:16099728-12] Siva K & Inamdar MS (2006) Rudhira is a cytoplasmic WD40 protein expressed in mouse embryonic stem cells and during embryonic erythropoiesis. Gene Expr Patterns 6: 225-34 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Kdr ( synonyms: Flk-1, Flk1, vascular endothelial growth factor receptor- 2, VEGF receptor-2, VEGFR-2, VEGFR2 )
Protein Name(s)	kinase insert domain protein receptor,
External Links
MGI	MGI:96683

MGI:Kdr

Contents

Annotations

Notes

References

a

b

c

e

g

h

i

k

l

m

n

o

p

p cont.

r

s

t

v

Personal tools

Namespaces

Variants

Views

Actions

Search

Navigation

Cacao

Journal Clubs

page contributors

Toolbox