GONUTS is under stress! The website is currently experiencing long-wait times and frequent time-outs due to the record number of students, groups, and annotations related to CACAO this semester. We are currently working on increasing performance -- please accept our apologies for the technical difficulties.
You can help reduce stress on the server by:
- not reloading pages frequently - this just adds
- opening links in new windows (so you can read the old page)
MGI:Jup
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Jup ( synonyms: gamma-catenin, PG, plakoglobin ) | |
| Protein Name(s) | junction plakoglobin, | |
| External Links | ||
| MGI | MGI:96650 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000902 |
cell morphogenesis |
MGI:MGI:4459044 |
PANTHER:PTHR23315 |
P |
From MGI |
|||
| GO:0002159 |
desmosome assembly |
MGI:MGI:1314706 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857539 |
P |
From MGI |
||
| GO:0002159 |
desmosome assembly |
MGI:MGI:3843580 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857539 |
P |
From MGI |
||
| GO:0002159 |
desmosome assembly |
MGI:MGI:85439 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857539 |
P |
From MGI |
||
| GO:0003136 |
negative regulation of heart induction by canonical Wnt receptor signaling pathway |
MGI:MGI:4459044 |
PANTHER:PTHR23315 |
P |
From MGI |
|||
| GO:0003181 |
atrioventricular valve morphogenesis |
MGI:MGI:4459044 |
PANTHER:PTHR23315 |
P |
From MGI |
|||
| GO:0003308 |
negative regulation of Wnt receptor signaling pathway involved in heart development |
MGI:MGI:4459044 |
PANTHER:PTHR23315 |
P |
From MGI |
|||
| GO:0003713 |
transcription coactivator activity |
MGI:MGI:4459044 |
PANTHER:PTHR23315 |
F |
From MGI |
|||
| GO:0003713 |
transcription coactivator activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005198 |
structural molecule activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005198 |
structural molecule activity |
MGI:MGI:4459044 |
PANTHER:PTHR23315 |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:2675927 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:2683390 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3027295 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005829 |
cytosol |
MGI:MGI:2675927 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005856 |
cytoskeleton |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0206 |
C |
From MGI |
||
| GO:0005886 |
plasma membrane |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005911 |
cell-cell junction |
MGI:MGI:2675927 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005911 |
cell-cell junction |
MGI:MGI:3826736 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005911 |
cell-cell junction |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005911 |
cell-cell junction |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005913 |
cell-cell adherens junction |
MGI:MGI:3574751 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005913 |
cell-cell adherens junction |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005913 |
cell-cell adherens junction |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005913 |
cell-cell adherens junction |
MGI:MGI:77405 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005915 |
zonula adherens |
MGI:MGI:4459044 |
PANTHER:PTHR23315 |
C |
From MGI |
|||
| GO:0005916 |
fascia adherens |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005916 |
fascia adherens |
MGI:MGI:4459044 |
PANTHER:PTHR23315 |
C |
From MGI |
|||
| GO:0007016 |
cytoskeletal anchoring at plasma membrane |
MGI:MGI:4459044 |
PANTHER:PTHR23315 |
P |
From MGI |
|||
| GO:0007155 |
cell adhesion |
MGI:MGI:2675927 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007369 |
gastrulation |
MGI:MGI:4459044 |
PANTHER:PTHR23315 |
P |
From MGI |
|||
| GO:0007398 |
ectoderm development |
MGI:MGI:4459044 |
PANTHER:PTHR23315 |
P |
From MGI |
|||
| GO:0007399 |
nervous system development |
MGI:MGI:4459044 |
PANTHER:PTHR23315 |
P |
From MGI |
|||
| GO:0009898 |
internal side of plasma membrane |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0009898 |
internal side of plasma membrane |
MGI:MGI:4459044 |
PANTHER:PTHR23315 |
C |
From MGI |
|||
| GO:0015629 |
actin cytoskeleton |
MGI:MGI:4459044 |
PANTHER:PTHR23315 |
C |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:3616720 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0016323 |
basolateral plasma membrane |
MGI:MGI:4459044 |
PANTHER:PTHR23315 |
C |
From MGI |
|||
| GO:0016327 |
apicolateral plasma membrane |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0016328 |
lateral plasma membrane |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0016331 |
morphogenesis of embryonic epithelium |
MGI:MGI:4459044 |
PANTHER:PTHR23315 |
P |
From MGI |
|||
| GO:0016337 |
cell-cell adhesion |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0016337 |
cell-cell adhesion |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0016337 |
cell-cell adhesion |
MGI:MGI:85439 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857539 |
P |
From MGI |
||
| GO:0016342 |
catenin complex |
MGI:MGI:4459044 |
PANTHER:PTHR23315 |
C |
From MGI |
|||
| GO:0016342 |
catenin complex |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0016477 |
cell migration |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0019901 |
protein kinase binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0019901 |
protein kinase binding |
MGI:MGI:4459044 |
PANTHER:PTHR23315 |
F |
From MGI |
|||
| GO:0019903 |
protein phosphatase binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0030018 |
Z disc |
MGI:MGI:81460 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0030054 |
cell junction |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0965 |
C |
From MGI |
||
| GO:0030057 |
desmosome |
MGI:MGI:1353237 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0030057 |
desmosome |
MGI:MGI:3027295 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0030057 |
desmosome |
MGI:MGI:3574751 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0030057 |
desmosome |
MGI:MGI:3843580 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857539 |
C |
From MGI |
||
| GO:0030057 |
desmosome |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0030057 |
desmosome |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0032993 |
protein-DNA complex |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0034747 |
Axin-APC-beta-catenin-GSK3B complex |
MGI:MGI:4459044 |
PANTHER:PTHR23315 |
C |
From MGI |
|||
| GO:0042153 |
RPTP-like protein binding |
MGI:MGI:3689290 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0042307 |
positive regulation of protein import into nucleus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043588 |
skin development |
MGI:MGI:85439 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857539 |
P |
From MGI |
||
| GO:0045111 |
intermediate filament cytoskeleton |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0045294 |
alpha-catenin binding |
MGI:MGI:2683390 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0045294 |
alpha-catenin binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0045296 |
cadherin binding |
MGI:MGI:4459044 |
PANTHER:PTHR23315 |
F |
From MGI |
|||
| GO:0045296 |
cadherin binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4459044 |
PANTHER:PTHR23315 |
P |
From MGI |
|||
| GO:0048599 |
oocyte development |
MGI:MGI:4459044 |
PANTHER:PTHR23315 |
P |
From MGI |
|||
| GO:0050982 |
detection of mechanical stimulus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0051091 |
positive regulation of sequence-specific DNA binding transcription factor activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0051291 |
protein heterooligomerization |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0071665 |
gamma-catenin-TCF7L2 complex |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0071681 |
cellular response to indole-3-methanol |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
|
colocalizes_with |
GO:0015629 |
actin cytoskeleton |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Bierkamp C et al. (1999) Desmosomal localization of beta-catenin in the skin of plakoglobin null-mutant mice. Development 126: 371-81 PubMed GONUTS page
- ↑ 2.0 2.1 Acehan D et al. (2008) Plakoglobin is required for effective intermediate filament anchorage to desmosomes. J Invest Dermatol 128: 2665-75 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Bierkamp C et al. (1996) Embryonic heart and skin defects in mice lacking plakoglobin. Dev Biol 180: 780-5 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Hatsell S et al. (2003) Plakoglobin is O-glycosylated close to the N-terminal destruction box. J Biol Chem 278: 37745-52 PubMed GONUTS page
- ↑ 5.0 5.1 Gual P et al. (2003) MAP kinases and mTOR mediate insulin-induced phosphorylation of insulin receptor substrate-1 on serine residues 307, 612 and 632. Diabetologia 46: 1532-42 PubMed GONUTS page
- ↑ 6.0 6.1 Cheng X et al. (2004) Assessment of splice variant-specific functions of desmocollin 1 in the skin. Mol Cell Biol 24: 154-63 PubMed GONUTS page
- ↑ Walker JL et al. (2008) Diverse roles of E-cadherin in the morphogenesis of the submandibular gland: insights into the formation of acinar and ductal structures. Dev Dyn 237: 3128-41 PubMed GONUTS page
- ↑ 8.0 8.1 Tunggal JA et al. (2005) E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions. EMBO J 24: 1146-56 PubMed GONUTS page
- ↑ Haegel H et al. (1995) Lack of beta-catenin affects mouse development at gastrulation. Development 121: 3529-37 PubMed GONUTS page
- ↑ Wu X et al. (2006) Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin. Genes Dev 20: 571-85 PubMed GONUTS page
- ↑ Butz S & Larue L (1995) Expression of catenins during mouse embryonic development and in adult tissues. Cell Adhes Commun 3: 337-52 PubMed GONUTS page
- ↑ Huelsken J et al. (2000) Requirement for beta-catenin in anterior-posterior axis formation in mice. J Cell Biol 148: 567-78 PubMed GONUTS page
- ↑ Besco JA et al. (2006) Intracellular substrates of brain-enriched receptor protein tyrosine phosphatase rho (RPTPrho/PTPRT). Brain Res 1116: 50-7 PubMed GONUTS page
