MGI:Jun

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05412	F	From MGI
	GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17325	F	From MGI
	GO:0001102	RNA polymerase II activating transcription factor binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05412	F	From MGI
	GO:0001525	angiogenesis	MGI:MGI:3654789 PMID:16847049^[1]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0001525	angiogenesis	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17325	P	From MGI
	GO:0001774	microglial cell activation	MGI:MGI:3772001 PMID:15233917^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2445420	P	From MGI
	GO:0001836	release of cytochrome c from mitochondria	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17325	P	From MGI
	GO:0001889	liver development	MGI:MGI:1338596 PMID:10352021^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2149630	P	From MGI
	GO:0001938	positive regulation of endothelial cell proliferation	MGI:MGI:3654789 PMID:16847049^[1]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0003151	outflow tract morphogenesis	MGI:MGI:1338596 PMID:10352021^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2149630	P	From MGI
	GO:0003677	DNA binding	MGI:MGI:1339874 PMID:10076871^[4]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003677	DNA binding	MGI:MGI:2664426 PMID:12798298^[5]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003677	DNA binding	MGI:MGI:4881409 PMID:19477969^[6]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003690	double-stranded DNA binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17325	F	From MGI
	GO:0003700	sequence-specific DNA binding transcription factor activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17325	F	From MGI
	GO:0003700	sequence-specific DNA binding transcription factor activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05412	F	From MGI
	GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05412	F	From MGI
	GO:0003713	transcription coactivator activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05412	F	From MGI
	GO:0005100	Rho GTPase activator activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05412	F	From MGI
	GO:0005515	protein binding	MGI:MGI:2664426 PMID:12798298^[5]	IPI: Inferred from Physical Interaction	UniProtKB:P54841	F	From MGI
	GO:0005515	protein binding	MGI:MGI:4819895 PMID:20516211^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q60739-1	F	From MGI
	GO:0005515	protein binding	MGI:MGI:5294529 PMID:20599664^[8]	IPI: Inferred from Physical Interaction	UniProtKB:Q15327	F	From MGI
	GO:0005634	nucleus	MGI:MGI:2385392 PMID:12050152^[9]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17325	C	From MGI
	GO:0005667	transcription factor complex	MGI:MGI:2664426 PMID:12798298^[5]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005667	transcription factor complex	MGI:MGI:2675699 PMID:12943993^[10]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005667	transcription factor complex	MGI:MGI:3719935 PMID:17182846^[11]	IPI: Inferred from Physical Interaction	UniProtKB:Q9QYB2 UniPRotKB:O09106 UniProtKB:P70288 UniProtKB:Q60520 UniProtKB:Q60974	C	From MGI
	GO:0005719	nuclear euchromatin	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05412	C	From MGI
	GO:0005829	cytosol	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17325	C	From MGI
	GO:0006351	transcription, DNA-dependent	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17325	P	From MGI
	GO:0006355	regulation of transcription, DNA-dependent	MGI:MGI:2176374 PMID:11818961^[12]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2149630	P	From MGI
	GO:0006366	transcription from RNA polymerase II promoter	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17325	P	From MGI
	GO:0007179	transforming growth factor beta receptor signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05412	P	From MGI
	GO:0007184	SMAD protein import into nucleus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05412	P	From MGI
	GO:0007612	learning	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17325	P	From MGI
	GO:0008134	transcription factor binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17325	F	From MGI
	GO:0008134	transcription factor binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05412	F	From MGI
	GO:0008284	positive regulation of cell proliferation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17325	P	From MGI
	GO:0008285	negative regulation of cell proliferation	MGI:MGI:3604168 PMID:16007074^[13]	IGI: Inferred from Genetic Interaction	MGI:MGI:88039	P	From MGI
	GO:0009314	response to radiation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17325	P	From MGI
	GO:0009987	cellular process	MGI:MGI:2176374 PMID:11818961^[12]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2149630	P	From MGI
	GO:0017053	transcriptional repressor complex	MGI:MGI:3719935 PMID:17182846^[11]	IPI: Inferred from Physical Interaction	UniProtKB:Q9QYB2 UniPRotKB:O09106 UniProtKB:P70288 UniProtKB:Q60520 UniProtKB:Q60974	C	From MGI
	GO:0030224	monocyte differentiation	MGI:MGI:3785353 PMID:18326819^[14]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0031103	axon regeneration	MGI:MGI:3772001 PMID:15233917^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2445420	P	From MGI
	GO:0031953	negative regulation of protein autophosphorylation	MGI:MGI:3662941 PMID:16916642^[15]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0032321	positive regulation of Rho GTPase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05412	P	From MGI
	GO:0035026	leading edge cell differentiation	MGI:MGI:2669352 PMID:12791271^[16]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2673694	P	From MGI
	GO:0035497	cAMP response element binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05412	F	From MGI
	GO:0042493	response to drug	MGI:MGI:87440 PMID:9098922^[17]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0042803	protein homodimerization activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17325	F	From MGI
	GO:0043065	positive regulation of apoptotic process	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17325	P	From MGI
	GO:0043066	negative regulation of apoptotic process	MGI:MGI:1338596 PMID:10352021^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2149630	P	From MGI
	GO:0043392	negative regulation of DNA binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05412	P	From MGI
	GO:0043524	negative regulation of neuron apoptotic process	MGI:MGI:3772001 PMID:15233917^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2445420	P	From MGI
	GO:0043525	positive regulation of neuron apoptotic process	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17325	P	From MGI
	GO:0043565	sequence-specific DNA binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17325	F	From MGI
	GO:0043922	negative regulation by host of viral transcription	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05412	P	From MGI
	GO:0043923	positive regulation by host of viral transcription	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05412	P	From MGI
	GO:0044212	transcription regulatory region DNA binding	MGI:MGI:3846264 PMID:19303854^[18]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0044212	transcription regulatory region DNA binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05412	F	From MGI
	GO:0045657	positive regulation of monocyte differentiation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17325	P	From MGI
	GO:0045740	positive regulation of DNA replication	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17325	P	From MGI
	GO:0045892	negative regulation of transcription, DNA-dependent	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05412	P	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17325	P	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05412	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:2664426 PMID:12798298^[5]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:3719935 PMID:17182846^[11]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:3846264 PMID:19303854^[18]	IGI: Inferred from Genetic Interaction	MGI:MGI:96648	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17325	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05412	P	From MGI
	GO:0046982	protein heterodimerization activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17325	F	From MGI
	GO:0046983	protein dimerization activity	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR011616	F	From MGI
	GO:0048146	positive regulation of fibroblast proliferation	MGI:MGI:3719935 PMID:17182846^[11]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0048146	positive regulation of fibroblast proliferation	MGI:MGI:3719935 PMID:17182846^[11]	IGI: Inferred from Genetic Interaction	MGI:MGI:1277991	P	From MGI
	GO:0048661	positive regulation of smooth muscle cell proliferation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17325	P	From MGI
	GO:0051365	cellular response to potassium ion starvation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17325	P	From MGI
	GO:0051726	regulation of cell cycle	MGI:MGI:2176374 PMID:11818961^[12]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2149630	P	From MGI
	GO:0051899	membrane depolarization	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17325	P	From MGI
	GO:0060395	SMAD protein signal transduction	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05412	P	From MGI
	GO:0070412	R-SMAD binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05412	F	From MGI
	GO:0071277	cellular response to calcium ion	MGI:MGI:3846264 PMID:19303854^[18]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0071837	HMG box domain binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17325	F	From MGI
colocalizes_with	GO:0000790	nuclear chromatin	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17325	C	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Zhang G et al. (2006) JUN siRNA regulates matrix metalloproteinase-2 expression, microvascular endothelial growth and retinal neovascularisation. J Cell Sci 119: 3219-26 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Raivich G et al. (2004) The AP-1 transcription factor c-Jun is required for efficient axonal regeneration. Neuron 43: 57-67 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Eferl R et al. (1999) Functions of c-Jun in liver and heart development. J Cell Biol 145: 1049-61 PubMed GONUTS page
↑ Ishige K et al. (1999) Characterization of absence seizure-dependent cyclic AMP responsive element-and activator protein 1 DNA-binding activities in lethargic (lh/lh) mice. Neurosci Lett 262: 53-6 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Mechta-Grigoriou F et al. (2003) c-jun regulation and function in the developing hindbrain. Dev Biol 258: 419-31 PubMed GONUTS page
↑ Kuratomi S et al. (2009) The cardiac pacemaker-specific channel Hcn4 is a direct transcriptional target of MEF2. Cardiovasc Res 83: 682-7 PubMed GONUTS page
↑ Da Costa CR et al. (2010) Bag1-L is a phosphorylation-dependent coactivator of c-Jun during neuronal apoptosis. Mol Cell Biol 30: 3842-52 PubMed GONUTS page
↑ Kojic S et al. (2010) A novel role for cardiac ankyrin repeat protein Ankrd1/CARP as a co-activator of the p53 tumor suppressor protein. Arch Biochem Biophys 502: 60-7 PubMed GONUTS page
↑ Hu J et al. (2002) A novel transactivating factor that regulates interferon-gamma-dependent gene expression. J Biol Chem 277: 30253-63 PubMed GONUTS page
↑ Ellsworth BS et al. (2003) The gonadotropin releasing hormone (GnRH) receptor activating sequence (GRAS) is a composite regulatory element that interacts with multiple classes of transcription factors including Smads, AP-1 and a forkhead DNA binding protein. Mol Cell Endocrinol 206: 93-111 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 Wu K et al. (2007) Cell fate determination factor DACH1 inhibits c-Jun-induced contact-independent growth. Mol Biol Cell 18: 755-67 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Passegué E et al. (2002) JunB can substitute for Jun in mouse development and cell proliferation. Nat Genet 30: 158-66 PubMed GONUTS page
↑ Nateri AS et al. (2005) Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development. Nature 437: 281-5 PubMed GONUTS page
↑ Schüler A et al. (2008) The MADS transcription factor Mef2c is a pivotal modulator of myeloid cell fate. Blood 111: 4532-41 PubMed GONUTS page
↑ Seo SR et al. (2006) Nuclear retention of the tumor suppressor cPML by the homeodomain protein TGIF restricts TGF-beta signaling. Mol Cell 23: 547-59 PubMed GONUTS page
↑ Li G et al. (2003) c-Jun is essential for organization of the epidermal leading edge. Dev Cell 4: 865-77 PubMed GONUTS page
↑ Wlodarczyk BC et al. (1996) Valproic acid-induced changes in gene expression during neurulation in a mouse model. Teratology 54: 284-97 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 Ezhkova E et al. (2009) Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells. Cell 136: 1122-35 PubMed GONUTS page

[PMID:16847049-0] 1.0 ^1.1 Zhang G et al. (2006) JUN siRNA regulates matrix metalloproteinase-2 expression, microvascular endothelial growth and retinal neovascularisation. J Cell Sci 119: 3219-26 PubMed GONUTS page

[PMID:15233917-1] 2.0 ^2.1 ^2.2 Raivich G et al. (2004) The AP-1 transcription factor c-Jun is required for efficient axonal regeneration. Neuron 43: 57-67 PubMed GONUTS page

[PMID:10352021-2] 3.0 ^3.1 ^3.2 Eferl R et al. (1999) Functions of c-Jun in liver and heart development. J Cell Biol 145: 1049-61 PubMed GONUTS page

[PMID:10076871-3] Ishige K et al. (1999) Characterization of absence seizure-dependent cyclic AMP responsive element-and activator protein 1 DNA-binding activities in lethargic (lh/lh) mice. Neurosci Lett 262: 53-6 PubMed GONUTS page

[PMID:12798298-4] 5.0 ^5.1 ^5.2 ^5.3 Mechta-Grigoriou F et al. (2003) c-jun regulation and function in the developing hindbrain. Dev Biol 258: 419-31 PubMed GONUTS page

[PMID:19477969-5] Kuratomi S et al. (2009) The cardiac pacemaker-specific channel Hcn4 is a direct transcriptional target of MEF2. Cardiovasc Res 83: 682-7 PubMed GONUTS page

[PMID:20516211-6] Da Costa CR et al. (2010) Bag1-L is a phosphorylation-dependent coactivator of c-Jun during neuronal apoptosis. Mol Cell Biol 30: 3842-52 PubMed GONUTS page

[PMID:20599664-7] Kojic S et al. (2010) A novel role for cardiac ankyrin repeat protein Ankrd1/CARP as a co-activator of the p53 tumor suppressor protein. Arch Biochem Biophys 502: 60-7 PubMed GONUTS page

[PMID:12050152-8] Hu J et al. (2002) A novel transactivating factor that regulates interferon-gamma-dependent gene expression. J Biol Chem 277: 30253-63 PubMed GONUTS page

[PMID:12943993-9] Ellsworth BS et al. (2003) The gonadotropin releasing hormone (GnRH) receptor activating sequence (GRAS) is a composite regulatory element that interacts with multiple classes of transcription factors including Smads, AP-1 and a forkhead DNA binding protein. Mol Cell Endocrinol 206: 93-111 PubMed GONUTS page

[PMID:17182846-10] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 Wu K et al. (2007) Cell fate determination factor DACH1 inhibits c-Jun-induced contact-independent growth. Mol Biol Cell 18: 755-67 PubMed GONUTS page

[PMID:11818961-11] 12.0 ^12.1 ^12.2 Passegué E et al. (2002) JunB can substitute for Jun in mouse development and cell proliferation. Nat Genet 30: 158-66 PubMed GONUTS page

[PMID:16007074-12] Nateri AS et al. (2005) Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development. Nature 437: 281-5 PubMed GONUTS page

[PMID:18326819-13] Schüler A et al. (2008) The MADS transcription factor Mef2c is a pivotal modulator of myeloid cell fate. Blood 111: 4532-41 PubMed GONUTS page

[PMID:16916642-14] Seo SR et al. (2006) Nuclear retention of the tumor suppressor cPML by the homeodomain protein TGIF restricts TGF-beta signaling. Mol Cell 23: 547-59 PubMed GONUTS page

[PMID:12791271-15] Li G et al. (2003) c-Jun is essential for organization of the epidermal leading edge. Dev Cell 4: 865-77 PubMed GONUTS page

[PMID:9098922-16] Wlodarczyk BC et al. (1996) Valproic acid-induced changes in gene expression during neurulation in a mouse model. Teratology 54: 284-97 PubMed GONUTS page

[PMID:19303854-17] 18.0 ^18.1 ^18.2 Ezhkova E et al. (2009) Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells. Cell 136: 1122-35 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Jun ( synonyms: c-jun, Junc )
Protein Name(s)	Jun oncogene,
External Links
MGI	MGI:96646

MGI:Jun

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